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TTK21

化学構造式
709676-56-2
CAS番号.
709676-56-2
化学名:
别名:
英語名:
TTK21
英語别名:
TTK2;TTK21;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
CBNumber:
CB34666838
化学式:
C17H15ClF3NO2
分子量:
357.75
MOL File:
709676-56-2.mol

TTK21 物理性質

沸点 :
369.8±42.0 °C(Predicted)
比重(密度) :
1.321±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
外見 :
A crystalline solid
酸解離定数(Pka):
12.22±0.70(Predicted)
InChI:
InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
InChIKey:
AQJBXYBDNZHZRE-UHFFFAOYSA-N
SMILES:
C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC

安全性情報

TTK21 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

TTK21 化学特性,用途語,生産方法

説明

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

使用

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

TTK21 上流と下流の製品情報

原材料

準備製品

TTK21 生産企業

Global( 45)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32686 60
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 4604 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4153 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 3501 55

709676-56-2()キーワード:

TTP22 4-[(E)-2-[(5,5,8,8-テトラメチル-5,6,7,8-テトラヒドロナフタレン)-2-イル]-1-プロペニル]安息香酸
  • 709676-56-2
  • TTK21
  • Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-
  • TTK21(CBP-p300 activator TTK21)
  • TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
  • TTK2
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