ニューロトロフィン-3, ヒト, 組換え体 化学特性,用途語,生産方法
溶解性
水に溶ける。
用途
薬理・生理作用研究用。
使用上の注意
本品は微量のため内容物を視認できないことがあります。蓋を開ける前は必ず遠心して下さい。
一般的な説明
NT-3 (neurotrophin 3) is a neurotrophic factor structurally related to β-NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6kDa polypeptide monomers (240 total amino acid residues). The amino acid sequences of human, murine and rat NT-3 are identical.
Biochem/physiol Actions
NT-3 (neurotrophin 3) promotes the growth and survival of nerve and glial cells. It is associated with neuroprotection and polymorphisms in the gene are associated with risk to Alzheimer′s disease. It is also linked with attention-deficit/hyperactivity disorder (ADHD) and mood disorders. NT-3 enhances the metastatic proliferation of breast cancer cells in the brain.
ニューロトロフィン-3, ヒト, 組換え体 上流と下流の製品情報
原材料
準備製品