GW583340 DIHYDROCHLORIDE
GW583340 DIHYDROCHLORIDE 物理性質
- 融点 :
- 259.8-262.4 °C(lit.)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO:9mg/mL
- 外見 :
- 個体
GW583340 DIHYDROCHLORIDE 価格
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GW583340 DIHYDROCHLORIDE 化学特性,用途語,生産方法
生物活性
Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.
GW583340 DIHYDROCHLORIDE 上流と下流の製品情報
原材料
準備製品
GW583340 DIHYDROCHLORIDE 生産企業
Global( 7)Suppliers
388082-81-3()キーワード:
- 388082-81-3
- 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P
- 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride
- 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-