(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩

(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TRCS680250	スペクチノマイシン二塩酸塩 Spectinomycin Dihydrochloride	21736-83-4	10g	￥69600	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCS680250	スペクチノマイシン二塩酸塩 Spectinomycin Dihydrochloride	21736-83-4	100g	￥359400	2023-06-01	購入
ナカライテスク株式会社(Nacalai)	32147-81	スペクチノマイシン二塩酸塩 ≧98.0%(無水物換算)(T) Spectinomycin Dihydrochloride ≧98.0%(無水物換算)(T)	21736-83-4	1G	￥9500	2024-03-01	購入

(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩 化学特性,用途語,生産方法

化学的特性

SPECTINOMYCIN DIHYDROCHLORIDE is White Powder

使用

SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.

定義

SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.

臨床応用

The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.

安全性プロファイル

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.

純化方法

The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].

(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩 上流と下流の製品情報

原材料

準備製品

(2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Jiangsu Guotai Guomian Trading Co. Ltd.	+86-512-58916079 +86-13601562190	pharmachem@gtgmt.com	China	148	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	744	58
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8822	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58

21736-83-4((2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩)キーワード:

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• 21736-83-4
• 8-beta,9-alpha,9a-alpha,10a-beta))-t
• 8-bis(methylamino)-,dihydrochloride,(2r-(2-alpha,4a-beta,5a-beta,6-beta,7-be
• (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one Hydrochloride
• SpectinoMycinHydrochloride for Injection
• 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-, hydrochloride(1:2), (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
• (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one, hydrochloride (1:2)
• U-18409AE
• SPECTINOMYCIN DIHYDROCHLORIDE
• SPECTINOMYCIN 2HCL
• ACTINOSPECTACIN DIHYDROCHLORIDE
• stanilo
• SPECTINOMYCIN READY MADE SOLUTION
• Spectinomycin2HClpentahydrate
• SPECTINOMYCINHYDROCHLORIDEANHYDROUS
• 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (9CI)
• 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]- (8CI)
• NSC 248616
• M 141
• Raw Material Spectinomycin Dihydrochloride / Spectinomycin HCL CAS 21736-83-4
• Spectinomycin dihydrochloride, >98%
• SPECTINOMYCIN DIHYDROC
• Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder
• SPECTINOMYCIN DIHYDROCHLORIDE USP/EP/BP
• (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride
• SPECTINOMYCIN HYDROCHLORIDE
• Methanomycin hydrochloride
• Spectinomycin (50mg/ml)
• Spectacomycin
• (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one hydrochloride
• スペクチノマイシン塩酸塩
• 塩酸スペクチノマイシン
• (2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン·2塩酸塩
• スペクチノマイシン二塩酸塩五水和物標準品
• スペクチノマイシン二塩酸塩
• (2R)-2,3,4a,5aβ,6,7,8,9,9aα,10aβ-デカヒドロ-4aβ,7β,9α-トリヒドロキシ-2α-メチル-6β,8β-ビス(メチルアミノ)-4H-ピラノ[2,3-b][1,4]ベンゾジオキシン-4-オン・2塩酸塩
• アミノグリコシド系抗生物質
• 泌尿器作用薬