デクスメデトミジン塩酸塩

デクスメデトミジン塩酸塩 化学構造式
145108-58-3
CAS番号.
145108-58-3
化学名:
デクスメデトミジン塩酸塩
别名:
デクスメデトミジン塩酸塩;(+)-メデトミジン塩酸塩;(S)-4-(α,2,3-トリメチベンジル)-1H-イミダゾール塩酸塩;(S)-4-[1-(2,3-ジメチルフェニル)エチル]-1H-イミダゾール塩酸塩;デクスメドエトミジン塩酸塩;デクスメデトミジン塩酸塩 (JAN)
英語名:
Dexmedetomidine hydrochloride
英語别名:
DEXMEDETOMIDINE HCL;Dexmedetomidine Hydrochloride Injection;Precedex;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride;4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE);CS-1397;DEMEDETOMIDINE HCL;Dexmedetomidine hydr
CBNumber:
CB3838381
化学式:
C13H17ClN2
分子量:
236.74
MOL File:
145108-58-3.mol

デクスメデトミジン塩酸塩 物理性質

融点 :
156.5-157.5°
比旋光度 :
+52.4° (c = 1 in water)
比重(密度) :
1.17 g/cm3
貯蔵温度 :
2-8°C
溶解性:
H2O: 可溶20mg/mL、透明
外見 :
色:
白からベージュ
光学活性 (optical activity):
[α]/D +48 to +58°, c = 1 in H2O
Merck :
14,2946
安定性::
Hygroscopic
InChI:
InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/s3
InChIKey:
VPNGEIHDPSLNMU-MERQFXBCSA-N
SMILES:
[C@@H](C1NC=NC=1)(C1C=CC=C(C)C=1C)C.Cl |&1:0,r|
CAS データベース:
145108-58-3(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-36/37/38
Sフレーズ  26-36/37/39
WGK Germany  3
RTECS 番号 NI5156750
HSコード  2933290000
絵表示(GHS) GHS hazard pictograms
注意喚起語 警告
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告 GHS hazard pictograms
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P301+P312 飲み込んだ場合:気分が悪い時は医師に連絡する こと。
P302+P352 皮膚に付着した場合:多量の水と石鹸で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

デクスメデトミジン塩酸塩 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC2749 デクスメドエトミジン塩酸塩
Dexmedetomidine hydrochloride
145108-58-3 10mg ¥68000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC2749 デクスメドエトミジン塩酸塩
Dexmedetomidine hydrochloride
145108-58-3 50mg ¥292000 2024-03-01 購入
東京化成工業 D5062 デクスメデトミジン塩酸塩 >98.0%(HPLC)(T)
Dexmedetomidine Hydrochloride >98.0%(HPLC)(T)
145108-58-3 20mg ¥9200 2024-03-01 購入
東京化成工業 D5062 デクスメデトミジン塩酸塩 >98.0%(HPLC)(T)
Dexmedetomidine Hydrochloride >98.0%(HPLC)(T)
145108-58-3 100mg ¥29500 2024-03-01 購入
Sigma-Aldrich Japan SML0956 デクスメデトミジン 塩酸塩 ≥98% (HPLC)
Dexmedetomidine hydrochloride ≥98% (HPLC)
145108-58-3 10mg ¥21300 2024-03-01 購入

デクスメデトミジン塩酸塩 化学特性,用途語,生産方法

外観

白色~わずかにうすい黄色, 結晶性粉末~粉末

溶解性

水に溶ける。

用途

α2 アドレナリン受容体作用 剤です。鎮静、鎮痛作用を示します。

効能

催眠鎮静薬, トランキライザー, α2アドレナリン受容体作動薬

商品名

プレセデックス (ファイザー); プレセデックス (ファイザー); プレセデックス (丸石製薬); プレセデックス (丸石製薬)

説明

Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepines or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.

物理的性質

Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1.

使用

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.

利点

The chemical name of dexmedetomidine hydrochloride is (S) -4- [1- (2,3- 3,5-dimethylphenyl) ethyl] -1H- imidazole hydrochlorides. Dexmedetomidine hydrochloride has an anti-sympathetic town. The effect of quiet and analgesic, compared with U.S. support pyrimidine, with higher selectivity and a short half-life, can be clinically used for Intensive Care Therapy. Start intubation and calmness using a lung ventilator patient during treatment. Meanwhile, the medicine can also reduce narcotic consumption, improve hand incidence of hemodynamic stability, and reduce myocardial ischaemia in art.

生物活性

Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

デクスメデトミジン塩酸塩 上流と下流の製品情報

原材料

準備製品


デクスメデトミジン塩酸塩 生産企業

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デクスメデトミジン塩酸塩  スペクトルデータ(1HNMR)


145108-58-3(デクスメデトミジン塩酸塩)キーワード:


  • 145108-58-3
  • 4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride
  • DeMedetoMidine hydrochloride
  • (S)-4-(1-(2,3-diMethylphenyl)ethyl)-1H-iMidazole hydrochloride
  • 1H-IMidazole,5-[(1S)-1-(2,3-diMethylphenyl)ethyl]-, hydrochloride (1:1)
  • 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride (1:1)
  • Dexmedetomidine hydrochloride 4-((S)-alpha,2,3-Trimethylbenzyl)imidazole monohydrochloride
  • (S)-Medetomidine hydrochloride
  • Given dexmedetomidine hydrochloride
  • Dexmedetomidine Hydrochloride (200 mg)
  • Dexmedetomidine HCl (Precedex)
  • (S)-5-(1-(2,3-DiMethylphenyl)ethyl)-1H-iMidazole hydrochloride
  • (S)-4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole Hydrochloride salt
  • DEXMEDETOMIDINE HYDROCHLORIDE
  • DEMEDETOMIDINE HCL
  • Dexmedetomidine(Pilot)
  • 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride
  • 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride
  • Dexmedetomidine hydrochloride, 99%, an agonist of adrenergic alpha-2 receptor
  • Dexmedetomidine HCl 99%
  • ((addition))-Medetomidine hydrochloride
  • CS-1397
  • Medetomidine Impurity 39(Dexmedetomidine HCl)
  • (+)-Medetomidine Hydrochloride
  • (S)-4-(alpha,2,3-Trimethybenzyl)-1H-imidazole Hydrochloride
  • Dexmedetomidine hydrochloride USP/EP/BP
  • Dexmedetomidine hydrogensulfate salt
  • Dexmedetomidine hydr
  • Omega cinnamate methyl ester
  • Dexmedetomidine HCl [(S)-Medetomidine
  • Dexmedetomidine HydrochlorideQ: What is Dexmedetomidine Hydrochloride Q: What is the CAS Number of Dexmedetomidine Hydrochloride Q: What is the storage condition of Dexmedetomidine Hydrochloride Q: What are the applications of Dexmedetomidine Hydrochloride
  • デクスメデトミジン塩酸塩
  • (+)-メデトミジン塩酸塩
  • (S)-4-(α,2,3-トリメチベンジル)-1H-イミダゾール塩酸塩
  • (S)-4-[1-(2,3-ジメチルフェニル)エチル]-1H-イミダゾール塩酸塩
  • デクスメドエトミジン塩酸塩
  • デクスメデトミジン塩酸塩 (JAN)
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