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2,6-ジイソプロピルフェノール

2,6-ジイソプロピルフェノール 化学構造式
2078-54-8
CAS番号.
2078-54-8
化学名:
2,6-ジイソプロピルフェノール
别名:
2,6-ジイソプロピルフェノール;プロポフォール;プロポホル;2,6-ビスイソプロピルフェノール;フレゾフォール;ジプリバン;ディプリバン;プロポホール;2,6ジイソプロピルフェノル;2,6- ジイソプロピルフェノール【プロポフォール】;2,6-ジイソプロピルフェノール(プロ ポホール);2,6-ジイソプロピルフェノール, 97%;プロポフォール (JAN)
英語化学名:
Propofol
英語别名:
Anepol;Ivofol;PD18215;AMpofol;Aquafol;Recofol;DIPRIVAN;Dipravan;Fresofol;NSC 5105
CBNumber:
CB4101882
化学式:
C12H18O
分子量:
178.27
MOL File:
2078-54-8.mol

2,6-ジイソプロピルフェノール 物理性質

融点 :
18 °C (lit.)
沸点 :
256 °C/764 mmHg (lit.)
比重(密度) :
0.962 g/mL at 25 °C (lit.)
蒸気圧:
5.6 mm Hg ( 100 °C)
屈折率 :
n20/D 1.514(lit.)
闪点 :
>230 °F
貯蔵温度 :
2-8°C
溶解性:
Very slightly soluble in water, miscible with hexane and with methanol
外見 :
neat
酸解離定数(Pka):
pKa 11.10(H2O,t =20)(Approximate)
水溶解度 :
Very slightly soluble in water.
Merck :
14,7834
BRN :
1866484
InChIKey:
OLBCVFGFOZPWHH-UHFFFAOYSA-N
CAS データベース:
2078-54-8(CAS DataBase Reference)
NISTの化学物質情報:
Phenol, 2,6-bis(1-methylethyl)-(2078-54-8)
EPAの化学物質情報:
2,6-Diisopropylphenol (2078-54-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,T,F
Rフレーズ  22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Sフレーズ  26-36/37/39-37/39-36-45-36/37-16-7
RIDADR  2810
WGK Germany  3
RTECS 番号 SL0810000
TSCA  Yes
国連危険物分類  6.1(b)
容器等級  III
HSコード  29089990
有毒物質データの 2078-54-8(Hazardous Substances Data)
消防法 危-4-3-III
化審法 (3)-521, (3)-526, (3)-2653, (4)-57
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P311 医師に連絡すること。
P405 施錠して保管すること。

2,6-ジイソプロピルフェノール 価格 もっと(24)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCP829750
Propofol
2078-54-8 5g ¥15000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCP829750
Propofol
2078-54-8 10g ¥17500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCP829750
Propofol
2078-54-8 50g ¥18800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCP829750
Propofol
2078-54-8 100g ¥22500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01AFAL06841 2,6-ジイソプロピルフェノール, 97%
2,6-Diisopropylphenol, 97%
2078-54-8 25g ¥8540 2021-03-23 購入

2,6-ジイソプロピルフェノール MSDS


Propofol

2,6-ジイソプロピルフェノール 化学特性,用途語,生産方法

外観

無色~黄褐色又は褐色、液体

用途

イソプロピルフェノール誘導 体です。GABAA 受容体に作用し、麻酔作用 を示します。

用途

イソプロピルフェノール誘導 体です。GABAA 受容体に作用し、麻酔作用 を示します。

効能

静脈麻酔薬, GABA-A受容体作動薬

商品名

ディプリバン (アスペンジャパン); ディプリバン (アスペンジャパン)

説明

Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.

化学的特性

Light Yellow Liquid

Originator

ICI (United Kingdom)

使用

2,6-DIPP is the active ingredient for intravenous anesthetic formulations, also has applications as an intermediate for polymers

使用

A anesthetic used in veterinary medicine

使用

Propofol is an anesthetic used in veterinary medicine.

brand name

Diprivan (Abraxis);Disoprivan;Disprofol;Rapinovet.

世界保健機関(WHO)

Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.

生物学の機能

Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney.
Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 712, 1956 DOI: 10.1021/jo01112a621

一般的な説明

Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.

生物活性

Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.

薬理学

Propofol is primarily a hypnotic drug with substantial cardiorespiratory depressant actions and with no ability to produce neuromuscular blockade. While propofol lacks analgesic properties, its use permits lower doses of opioids. Likewise, less propofol is required for adequate hypnosis when it is administered with opioids.Thus, it is said that propofol and opioids interact synergistically.

臨床応用

Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.

副作用

The dose of propofol should be reduced in older patients; however, it does have a relatively linear dose– response characteristic, and patients generally can be safely titrated. The pain on injection, especially when small veins are used, can be considerably reduced if lidocaine 20 mg is administered first.
Anesthesia induction with propofol causes a significant reduction in blood pressure that is proportional to the severity of cardiovascular disease or the volume status of the patient, or both. However, even in healthy patients a significant reduction in systolic and mean arterial blood pressure occurs. The reduction in pressure appears to be associated with vasodilation and myocardial depression. Although propofol decreases systemic vascular resistance, reflex tachycardia is not observed. This is in contrast to the actions of thiopental. The heart rate stabilization produced by propofol relative to other agents is likely the result of either resetting or inhibiting the baroreflex, thus reducing the tachycardic response to hypotension.
Since propofol does not depress the hemodynamic response to laryngoscopy and intubation, its use may permit wide swings in blood pressure at the time of induction of anesthesia. Propofol should be used with utmost caution in patients with cardiac disease.

安全性プロファイル

Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOL

Veterinary Drugs and Treatments

In appropriate patients, propofol may be useful as an induction agent (especially before endotracheal intubation or an inhalant anesthetic), and as an anesthetic for outpatient diagnostic or minor procedures (e.g., laceration repair, radiologic procedures, minor dentistry, minor biopsies, endoscopy, etc.).
Propofol is used as a treatment for refractory status epilepticus, as it tends to cause less cardiovascular depression and recoveries can be smoother than with pentobarbital. Propofol may be of particular usefulness for use in Greyhounds and in patients with preexisting cardiac dysrhythmias. At low dosages, propofol is being investigated as an appetite stimulant in dogs.
Propofol may be safely used in animals with liver or renal disease and mild to moderate cardiac disease.
In dogs, propofol’s labeled indications are: 1) for induction of anesthesia; 2) for maintenance of anesthesia for up to 20 minutes; 3) for induction of general anesthesia where maintenance is provided by inhalant anesthetics.

2,6-ジイソプロピルフェノール 上流と下流の製品情報

原材料

準備製品


2,6-ジイソプロピルフェノール 生産企業

Global( 347)Suppliers
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2078-54-8(2,6-ジイソプロピルフェノール)キーワード:


  • 2078-54-8
  • 2,6-DIISOPROPYLPHENOL
  • 2,6-BIS(1-METHYLETHYL)PHENOL
  • Diprivan10
  • Disoprofol
  • PD18215
  • Phenol, 2,6-diisopropyl-
  • Phenol,2,6-bis(1-methylethyl)-
  • Phenol,2,6-diisopropyl-
  • propofol(INN)
  • DISOPRIVAN
  • DIPRIVAN
  • ICI-35868
  • Dipravan
  • AMpofol
  • Anepol
  • Aquafol
  • Diprifusor
  • Fresofol
  • Ivofol
  • NSC 5105
  • Propofol USP
  • Propofol Ph. Eur.
  • 2,6- twoisopropyl phenol
  • Propofol solution
  • Propofol RAPINOVET
  • RAPINOVET
  • PROPOFOL
  • PROPOTOL
  • 2,6-bis(1-methylethyl)-pheno
  • 2,6-Bis(isopropyl)phenol
  • 2,6-ジイソプロピルフェノール
  • プロポフォール
  • プロポホル
  • 2,6-ビスイソプロピルフェノール
  • フレゾフォール
  • ジプリバン
  • ディプリバン
  • プロポホール
  • 2,6ジイソプロピルフェノル
  • 2,6- ジイソプロピルフェノール【プロポフォール】
  • 2,6-ジイソプロピルフェノール(プロ ポホール)
  • 2,6-ジイソプロピルフェノール, 97%
  • プロポフォール (JAN)
  • 抗痙攣薬
  • 麻酔薬
  • 全身麻酔
  • 鎮吐薬
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