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リドカイン注射液

リドカイン注射液 化学構造式
73-78-9
CAS番号.
73-78-9
化学名:
リドカイン注射液
别名:
キシロシチン塩酸塩;キシロカード;キシロカイン塩酸塩;キシロトックス;塩酸リドカイン;2-(ジエチルアミノ)-N-(2,6-ジメチルフェニル)アセトアミド·塩酸塩;キシロカルド;キシカイン塩酸塩;リドカイン塩酸塩;リグノカイン塩酸塩;リドカイン注射液;リドカイン塩酸塩 (JAN);リドカイン注射液 (JP17)
英語化学名:
Lidocaine hydrochloride
英語别名:
s202;v262;xylocard;xyloneural;LIDOCAINE HCL;Lidocaine HCI;Sell Lidocaine;Lithium Claviate;Licain Monohydrate;Coluracetam powder
CBNumber:
CB4117973
化学式:
C14H23ClN2O
分子量:
270.8
MOL File:
73-78-9.mol

リドカイン注射液 物理性質

融点 :
80-82°C
貯蔵温度 :
Inert atmosphere,2-8°C
CAS データベース:
73-78-9(CAS DataBase Reference)
EPAの化学物質情報:
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride (73-78-9)

安全性情報

RIDADR  3249
国連危険物分類  6.1(b)
容器等級  III
毒性 LD50 oral in mouse: 220mg/kg

リドカイン注射液 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC468385
LIDOCAINE HCL
73-78-9 100g ¥35600 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC468385
LIDOCAINE HCL
73-78-9 500g ¥105600 2021-03-23 購入

リドカイン注射液 化学特性,用途語,生産方法

効能

局所麻酔薬, 抗不整脈薬, ナトリウムチャネル遮断薬

商品名

オリベス (高田製薬); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); キシロカイン (アスペンジャパン); リドカイン (ナガセ医薬品); リドカイン (ナガセ医薬品); リドカイン (高田製薬)

化学的特性

White to Off-White Solid

Originator

Xylocaine,Astra,US,1949

使用

Apply to affected site 5 to 10 minutes before procedure. Duration of anesthesia is relatively short (<1 hour).

使用

Local anesthesic;Na+ channel blocker

使用

Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

定義

ChEBI: The anhydrous form of the hydrochloride salt of lidocaine.

Manufacturing Process

One mol of 2,6-xylidine is dissolved in 800 ml glacial acetic acid. The mixture is cooled to 10°C, after which 1.1 mol chloracetyl chloride is added at one time. The mixture is stirred vigorously during a few moments after which 1,000 ml half-saturated sodium acetate solution, or other buffering or alkalizing substance, is added at one time. The reaction mixture is shaken during half an hour. The precipitate formed which consists of ω-chloro-2,6- dimethyl-acetanilide is filtered off, washed with water and dried. The product is sufficiently pure for further treatment. The yield amounts to 70 to 80% of the theoretical amount.
One mole of the chloracetyl xylidide thus prepared and 2.5 to 3 mols diethyl amine are dissolved in 1,000 ml dry benzene. The mixture is refluxed for 4 to 5 hours. The separated diethyl amine hydrochloride is filtered off. The benzene solution is shaken out two times with 3N hydrochloric acid, the first time with 800 ml and the second time with 400 ml acid. To the combined acid extracts is added an approximately 30% solution of sodium hydroxide until the precipitate does not increase.
The precipitate, which sometimes is an oil, is taken up in ether. The ether solution is dried with anhydrous potassium carbonate after which the ether is driven off. The remaining crude substance is purified by vacuum distillation. During the distillation practically the entire quantity of the substance is carried over within a temperature interval of 1° to 2°C. The yield approaches the theoretical amount. MP 68° to 69°C. BP 180° to 182°C at 4 mm Hg; 159° to 160°C at 2 mm Hg. (Procedure is from US Patent 2,441,498.)

brand name

Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).

Therapeutic Function

Local anesthetic, Antiarrhythmic

生物学の機能

Lidocaine hydrochloride (Xylocaine) is the most commonly used local anesthetic. It is well tolerated, and in addition to its use in infiltration and regional nerve blocks, it is commonly used for spinal and topical anesthesia and as an antiarrhythmic agent. Lidocaine has a more rapidly occurring, more intense, and more prolonged duration of action than does procaine.

一般的な説明

Lidocaine hydrochloride,2-(diethylamino)-2 ,6 -acetoxylidide monohydrochloride(Xylocaine), was conceived as a derivative of gramine(3-dimethylaminomethylindole) and introduced as a localanesthetic. It is now being used intravenously as a standardparenteral agent for suppression of arrhythmias associatedwith acute myocardial infarction and cardiac surgery.It isthe drug of choice for the parenteral treatment of prematureventricular contractions.

臨床応用

Lidocaine hydrochloride is a class IB antiarrhythmicagent with a different effect on the electrophysiologicalproperties of myocardial cells from that of procainamideand quinidine. It binds with equal affinity to the active (A)and inactive (I) Na+ ion channels. It depresses diastolic depolarizationand automaticity in the Purkinje fiber networkand increases the functional refractory period relative toaction potential duration, as do procainamide and quinidine.It differs from the latter two drugs, however, in that it doesnot decrease, and may even enhance, conduction velocity and increase membrane responsiveness to stimulation.There are fewer data available on the subcellular mechanismsresponsible for the antiarrhythmic actions of lidocainethan on the more established drug quinidine. It has been proposedthat lidocaine has little effect on membrane cation exchangeof the atria. Sodium ion entrance into ventricularcells during excitation is not influenced by lidocaine becauseit does not alter conduction velocity in this area.Lidocaine hydrochloride does depress Na+ influx duringdiastole, as do all other antiarrhythmic drugs, to diminishautomaticity in myocardial tissue. It also alters membraneresponsiveness in Purkinje fibers, allowing increased conductionvelocity and ample membrane potential at the timeof excitation.

安全性プロファイル

Poison by ingestion, intraperitoneal, intravenous, subcutaneous, intramuscular, and intratracheal routes. Human systemic effects: somnolence, respiratory depression, low blood pressure, cardiomyopathy includmg infarction, pulse rate increase. An experimental teratogen. Other experimental reproductive effects. A skin and eye irritant. An anesthetic. When heated to decomposition it emits very toxic fumes of NOx and HCl.

リドカイン注射液 上流と下流の製品情報

原材料

準備製品


リドカイン注射液 生産企業

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73-78-9(リドカイン注射液)キーワード:


  • 73-78-9
  • LIGNOCAINE HYDROCHLORIDE
  • LIDOCAINE HYDROCHLORIDE
  • LIDOCAINE HCL
  • Lidocaine hydrochloride CP2000,BP98
  • a-(diethylamino)-26-acetoxylidideHCl
  • a-(diethylamino)-26-acetoxylididehydrochloride
  • Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride 2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid monohydrochloride alpha-diethylamino-2,6-acetoxylidine hydrochloride anestacon hydrochloride duncaine hydrochloride
  • 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride
  • 6’-acetoxylidide,2-(diethylamino)-2hydrochloride
  • 6’-acetoxylidide,2-(diethylamino)-2monohydrochloride
  • Acetamide,2-(diethylamino)-N-(2,6-diethylphenyl)-,monohydrochloride
  • Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-,monohydrochloride
  • alpha-diethylamino-2,6-acetoxylidinehydrochloride
  • anestaconhydrochloride
  • duncainehydrochloride
  • gravocainhydrochloride
  • isicainehydrochloride
  • leostesinhydrochloride
  • lidocainhydrochloride
  • lidothesinhydrochloride
  • n-(diethylaminoacetyl)-2,6-dimethylanilinehydrochloride
  • omega-diethylamino-2,6-dimethylacetanilidehydrochloride
  • rucainahydrochloride
  • s202
  • v262
  • xycainehydrochloride
  • xylestesinhydrochloride
  • xylocainehydrochloride
  • xylocard
  • xylocitinhydrochloride
  • キシロシチン塩酸塩
  • キシロカード
  • キシロカイン塩酸塩
  • キシロトックス
  • 塩酸リドカイン
  • 2-(ジエチルアミノ)-N-(2,6-ジメチルフェニル)アセトアミド·塩酸塩
  • キシロカルド
  • キシカイン塩酸塩
  • リドカイン塩酸塩
  • リグノカイン塩酸塩
  • リドカイン注射液
  • リドカイン塩酸塩 (JAN)
  • リドカイン注射液 (JP17)
  • 歯科用薬
  • 局所麻酔薬
  • 抗不整脈薬
  • 口腔用薬
  • 眼科用薬
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