エルタペネム二ナトリウ
エルタペネム二ナトリウ 物理性質
- 融点 :
- 230-234°C (dec.)
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- メタノール（微量）、水（微量）
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- 安定性：:
- 常温では不安定！
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
エルタペネム二ナトリウ 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE635000 |
エルタペネム二ナトリウム 90%
Ertapenem Disodium 90% |
153832-38-3 |
10mg |
￥73500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCE635000 |
エルタペネム二ナトリウム 90%
Ertapenem Disodium 90% |
153832-38-3 |
100mg |
￥323400 |
2024-03-01 |
購入 |
エルタペネム二ナトリウ 化学特性,用途語,生産方法
効能
抗生物質, 細胞壁合成阻害薬
説明
Ertapenem sodium was introduced in the US as a once daily intravenous or
intramuscular injection for the treatment of adult patients with moderate to severe bacterial
infections. This new I-β-methyl carbapenem can be assembled from commercially
available 4-nitrobenzyl protected β-methyl carbapenem enolphosphate and the appropriate
thiol derivative. The last intermediate can be synthesized from a suitably N-protected 4-
hydroxy proline derivative in a one pot operation involving bis activation of the carboxy and
hydroxy groups, reaction with sodium sulfide yielding the corresponding thiolactone,
aminolysis with 2-aminobenzoic acid and Kdeprotection. This bacterial cell wall synthesis
inhibitor has broad spectrum antimicrobial activity including common Gram-positive and
Gram-negative aerobic pathogens and restricted activity against nosocomial pathogens
such as Pseudomonas aeruginosa, Acinetobacfer species, methicillin-resistant
staphylococci and enterococci. Ertapenem is resistant to a broad and extended spectrum
of β-lactamases (excluding metallo-beta-lactamase) and is also more resistant than
imipenem to human renal dehydroxypeptidase-I-inactivation (DHP-I). In drug-resistant
strains of P. aeruginosa, resistance to ertapenem and imipenem was common but almost
all strains remain susceptible to at least one antipseudomal agent. In phase III studies,
ertapenem showed efficacy in the treatment of obstetric and gyneacological infections,
skin and soft tissues infections, community-acquired pneumonia, urinary tract infections
and in intra abdominal infections. Ertapenem has improved pharmacokinetics over
currently available carbapenems and cephalosporins with an extended serum half-life of 4h. The overall safety and tolerability profile of ertapenem was comparable to that seen with
comparator antibacterials.
化学的特性
Pale Yellow Solid
使用
Group 1 carbapenem antibiotic. An antibacterial.
エルタペネム二ナトリウ 上流と下流の製品情報
原材料
準備製品
エルタペネム二ナトリウ 生産企業
Global( 119)Suppliers
エルタペネム二ナトリウ スペクトルデータ(1HNMR)
153832-38-3(エルタペネム二ナトリウ)キーワード:
- 153832-38-3
- 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
- ErtapeneM SodiuM(crude)
- disodium (4R,5R,6S)-3-[(3S,5S)-5-[(3-carboxylatophenyl)carbamoyl]pyrro lidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2 .0]hept-2-ene-2-carboxylate
- Ertapenem disodium
- Ertapenem Disodium (85%)
- Ertapenem (sodium salt)
- Ertapenam disodium
- Ertapenem Disodium 90%
- ERTAPENEM NA
- Ertapenem Disodium USP/EP/BP
- sodium (4R,5S,6S)-3-(((3S,5S)-5-((3-carboxylatophenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
- sodium 3-((2S,4S)-4-(((4R,5S,6S)-2-carboxy-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate
- 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, sodium salt (1:2), (4R,5S,6S)-
- エルタペネム二ナトリウ
- エルタペネム二ナトリウム 90%
- エルタペネムナトリウム
- ナトリウム (4R,5S,6S)-6-[(1R)-1-ヒドロキシエチル]-4-メチル-7-オキソ-3-{[(3S,5S)-5-({3-[(ソジオオキシ)カルボニル]フェニル}カルバモイル)ピロリジン-3-イル]スルファニル}-1-アザビシクロ[3.2.0]ヘプタ-2-エン-2-カルボキシラート
- エルタペネムジナトリウム
- (4R,5S,6S)-3-[[(3S,5S)-5-[[3-(ソジオオキシカルボニル)フェニル]カルバモイル]ピロリジン-3-イル]チオ]-4-メチル-6-[(R)-1-ヒドロキシエチル]-7-オキソ-1-アザビシクロ[3.2.0]ヘプタ-2-エン-2-カルボン酸ナトリウム