レルカニジピン
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- CAS番号.
- 100427-26-7
- 化学名:
- レルカニジピン
- 别名:
- 2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロ-3,5-ピリジンジカルボン酸5-メチル3-[2-[(3,3-ジフェニルプロピル)メチルアミノ]-1,1-ジメチルエチル];レルカニジピン;マスニジピン;1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)-3,5-ピリジンジカルボン酸3-[2-[(3,3-ジフェニルプロピル)メチルアミノ]-1,1-ジメチルエチル]5-メチル;2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロ-3,5-ピリジンジカルボン酸3-メチル5-[1,1-ジメチル-2-[メチル(3,3-ジフェニルプロピル)アミノ]エチル];3-{1-[(3,3-ジフェニルプロピル)(メチル)アミノ]-2-メチルプロパン-2-イル} 5-メチル 2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート
- 英語名:
- Lercanidipine
- 英語别名:
- Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineQ: What is
Lercanidipine Q: What is the CAS Number of
Lercanidipine Q: What is the storage condition of
Lercanidipine
- CBNumber:
- CB4133658
- 化学式:
- C36H41N3O6
- 分子量:
- 611.73
- MOL File:
- 100427-26-7.mol
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レルカニジピン 物理性質
- 融点 :
- 118-120°C
- 沸点 :
- 712.5±60.0 °C(Predicted)
- 比重(密度) :
- 1.177±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- Soluble in DMSO
- 外見 :
- Powder
- 酸解離定数(Pka):
- 8.66±0.50(Predicted)
- CAS データベース:
- 100427-26-7(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
レルカニジピン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
レルカニジピン 化学特性,用途語,生産方法
効能
血圧降下薬, カルシウムチャネル遮断薬
説明
Lerdip was launched in the Netherlands for hypertension. It is prepared in
four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]-
2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl
3-aminocrotonate. This compound was designed to be very lipophilic which imparts
the drug with a gradual onset and a long duration of action as a result of prolonged
exposure to receptors by partitioning into membranes. It is an antagonist of L-type
calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any
myocardial contractility impairment, has no neuroendocrine activation, and has
negligible affinity for neurotransmitter receptors such as α
1- and α
2-adrenergic
receptors. While sold as a racemate, the calcium channel activity is found in the (S)-
isomer with the (R)-isomer being 2-orders of magnitude less active. It has an
increased cardiac contractility index which is much more than Nitrendipine or
nifedipine. The good selectivity causes a reduction in blood pressure with no negative
inotropic effects.
使用
Antihypertensive compound; calcium channel blocker.
レルカニジピン 上流と下流の製品情報
原材料
準備製品
レルカニジピン 生産企業
Global( 155)Suppliers
100427-26-7(レルカニジピン)キーワード:
- 100427-26-7
- LERCANIDIPINE
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER
- methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- LercanidipineC36H41N306
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester
- 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester
- Masnidipine
- Rec-15-2375
- LERCANIDIPINE(FORR&DONLY)
- Lercanidipine 13C-d3
- 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
- Lercanadipine
- Lercanidipine USP/EP/BP
- LercanidipineQ: What is
Lercanidipine Q: What is the CAS Number of
Lercanidipine Q: What is the storage condition of
Lercanidipine
- 2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロ-3,5-ピリジンジカルボン酸5-メチル3-[2-[(3,3-ジフェニルプロピル)メチルアミノ]-1,1-ジメチルエチル]
- レルカニジピン
- マスニジピン
- 1,4-ジヒドロ-2,6-ジメチル-4-(3-ニトロフェニル)-3,5-ピリジンジカルボン酸3-[2-[(3,3-ジフェニルプロピル)メチルアミノ]-1,1-ジメチルエチル]5-メチル
- 2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロ-3,5-ピリジンジカルボン酸3-メチル5-[1,1-ジメチル-2-[メチル(3,3-ジフェニルプロピル)アミノ]エチル]
- 3-{1-[(3,3-ジフェニルプロピル)(メチル)アミノ]-2-メチルプロパン-2-イル} 5-メチル 2,6-ジメチル-4-(3-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート