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β-カロテン

β-カロテン 化学構造式
7235-40-7
CAS番号.
7235-40-7
化学名:
β-カロテン
别名:
β-カロテン;C.I.フードオレンジ5;trans-β-カロテン;β,β-カロテン;(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-テトラメチル-1,18-ビス(1,3,3-トリメチルシクロヘキセン-2-イル)-1,3,5,7,9,11,13,15,17-オクタデカノナエン;β-カロチン;all-trans-β-カロテン;βカロテン;Β-カロテン標準品;ベータカロチン;カロチン;プロビタミンA;Β‐カロテン標準品;カロテン, Β-;ベータカロテン
英語化学名:
beta-Carotene
英語别名:
Kpmk;C40H56;BetaVit;Carotin;NatruaL;Karotin;Serlabo;Daucene;SOLATENE;Carotene
CBNumber:
CB4148267
化学式:
C40H56
分子量:
536.89
MOL File:
7235-40-7.mol

β-カロテン 物理性質

融点 :
178-179 °C
沸点 :
644.94°C (rough estimate)
比重(密度) :
1.000
屈折率 :
1.5630 (estimate)
闪点 :
103 °C
貯蔵温度 :
-20°C
溶解性:
hexane: 100 μg/mL, soluble
外見 :
powder
色:
red to purple
水溶解度 :
Soluble in hexane, dimethyl sulfoxide, benzene, chloroform, cyclohexane. Insoluble in water.
Sensitive :
Air & Light Sensitive
Merck :
14,1853
BRN :
1917416
安定性::
Stable, but sensitive to air, heat and light. Store at -20C under nitrogen. Pyrophoric - may ignite spontaneously in air at room temperature.
InChIKey:
OENHQHLEOONYIE-JLTXGRSLSA-N
CAS データベース:
7235-40-7(CAS DataBase Reference)
NISTの化学物質情報:
«beta» Carotene(7235-40-7)
EPAの化学物質情報:
.beta.,.beta.-Carotene (7235-40-7)

安全性情報

主な危険性  Xn
Rフレーズ  44-36/37/38-20/21/22
Sフレーズ  7-15-18-36-26-24/25
WGK Germany  1
RTECS 番号 FI0329500
1-8-10-16
TSCA  Yes
HSコード  32030019
有毒物質データの 7235-40-7(Hazardous Substances Data)
化審法 (8)-496, (9)-302

β-カロテン 価格 もっと(30)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00003211 カロテン, β-
Carotene, B-
7235-40-7 5mg ¥19100 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01ACSVIT-019N β-カロテン
Beta-Carotene
7235-40-7 10mg ¥7400 2021-03-23 購入
東京化成工業 C0560 β-カロテン >97.0%(E)
β-Carotene >97.0%(E)
7235-40-7 5g ¥7600 2021-03-23 購入
東京化成工業 C0560 β-カロテン >97.0%(E)
β-Carotene >97.0%(E)
7235-40-7 1g ¥2500 2021-03-23 購入
関東化学株式会社(KANTO) 08184-97 β‐カロテン標準品 >95.0%(HLC)
β‐Carotene standard >95.0%(HLC)
7235-40-7 200mg ¥8000 2021-03-23 購入

β-カロテン MSDS


beta,beta-Carotene

β-カロテン 化学特性,用途語,生産方法

外観

暗紫色~暗紫褐色, 結晶性粉末

定義

本品は、合成又は天然から得られるカロテノイド化合物であり、次の化学式で表される。

溶解性

クロロホルムにやや溶けやすく、シクロヘキサンに溶けにくく、エタノールに極めて溶けにくく、水にほとんど溶けない。

解説

カロチノイド色素の中で生物界に最も広く分布する代表的物質。カロテンとも呼ぶ。分子式C40H56を有する炭化水素。分子の中央に存在するポリエン鎖をはさむ両端のイオノン環の構造によりα,β,γ,δ,εなど多くの異性体が存在する。リコピンlycopeneもカロチンの異性体であり広義のカロチンに含むこともある。β‐カロチンはその中で最も広く分布しまたその量も多い。ニンジンの根,トウガラシの実,また緑葉中にクロロフィルとつねに共存する。
株式会社平凡社 世界大百科事典 第2版について 情報

用途

薬理研究用、黄色着色料。

用途

カロテン定量用標準品。

化粧品の成分用途

皮膚コンディショニング剤、着色剤

効能

紫外線保護剤

使用上の注意

不活性ガス封入空気及び光により変化し、発熱分解しやすい。最終的には、空気により自己発火することがある。

説明

b-Carotene is applied as a food coloring additive, as provitamin A in food and feed, in multivitamin products, as an antioxidant, and as a colorant for cosmetics. In the literature, a number of microorganisms are described that are capable of accumulating b-carotene up to relatively high levels, for example, the fungi B. trispora, Phycomyces blakesleanus, the yeast Rhodotorula glutinis, and the above-mentioned alga D. salina. Production processes were developed with mutants of B. trispora in the former Soviet Union (cf. Sect. 2.3) and for D. salina.
Among the b-carotene–producing algae, D. salina is currently the best-known and most efficient producer: D. salina cells are able to synthesize b-carotene in levels a thousand times higher than those of carrots. Dunaliella is also able to synthesize a-carotene, violaxanthin, neoxanthin, zeaxanthin, and lutein. The unicellular green alga D. salina is grown in open ponds without (hardly any) process control. It was shown that the highest production levels were obtained with high light intensities, nitrogen limitation, and stress-inducing temperatures. This has resulted in b-carotene levels up to 12 % of the dry mass. The production facilities are located in places where optimum conditions are found, namely in Australia, Israel, and in the United States; these places benefit from a lot of sunshine, little cloudiness, the availability of saline water, and high average temperatures.

化学的特性

solid

Originator

Carotaben,Hermal,W. Germany,1975

天然物の起源

Beta-carotene is available naturally in fruits and vegetables. Synthetically, it may be manufactured from fungi or algae.

使用

Beta-Carotene is a colorant that is a carotenoid producing a yellow to orange hue. it has good tinctorial strength, fair light stability, poor oxidation stability, and good ph stability. it is insoluble in water but is available in water-dispersible, oil-dispersible, and oil- soluble forms. it has vitamin a activity. it has a natural resistance to ascorbic acid reduction in beverages and thus is used in orange- colored liquid products. it is used in margarine, oils, cheese, and puddings at levels required to produce the desired color. related colorants are canthaxanthin and beta-apo-8-carotenal.

使用

antioxidant; provitamin A

使用

Yellow coloring agent for foods.

使用

beta-carotene is a known anti-oxidant. It has demonstrated photo protection properties particularly when taken internally. It is also used as a yellow-orange color additive. Beta-carotene is a caratinoid and a precursor to vitamin A. It is beneficial for dry and flaking skin. naturally occurring in fruits and vegetables that contain orange-yellow pigment, such as apricots, carrots, mangoes, and oranges, beta-carotene can also be synthetically manufactured.

使用

Most important of the provitamins A. Widely distributed in the plant and animal kingdom. In plants it occurs almost always together with chlorophyll. Vitamin A precursor. Ultraviolet screen

定義

ChEBI: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.

Manufacturing Process

3.6 g (0.023 mol) of 3,8-dimethyl-3,5,7-decatrien-1,9-diyne were dissolved in 50 ml of absolute ether, and to the solution was added 0.05 mol of ethereal phenyl-lithium solution. The mixture was refluxed for 30 minutes. Then a solution of 11 g (0.05 mol) of 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-methyl- 2-buten-1-al in 100 ml of ether was added dropwise, and the reaction mixture was boiled for 2 hours. The reaction mixture was then hydrolyzed with aqueous ammonium acetate solution, and the ethereal layer was separated, dried and concentrated. The residue, i.e., 1,18-di(2,6,6-trimethyl-1- cyclohexen-1-yl)-3,7,12,16-tetramethyl-4,15-dihydroxy-2,7,9,11,16- octadecapentaen-5,13-diyne, was a resinous product (having 1.9 active hydrogen atoms and absorption maxima in the ultraviolet spectrum at 326 and 341 nm) which was used for the next step without any further purification. The resin was dissolved in 200 ml of methylene chloride, 10 ml of glacial acetic acid were added to the solution, and the mixture was cooled to - 40°C in a carbon dioxide atmosphere, while stirring. Then, 9 ml of aqueous hydrobromic acid (60%) were added in one portion, the mixture was stirred at -35°C for 1.5 minutes, and subsequently 200 ml of ice water were run into the mixture. After further stirring the mixture for 2 hours at 0°C, the methylene chloride layer was separated, washed with water and sodium bicarbonate solution, dried with Na2SO4 andconcentrated in vacuo. The residue, i.e., 11,12-11',12'-bisdehydro-betta-carotene, was a tough resin or a foamy solid (having no active hydrogen atoms and possessing absorption maxima in the ultraviolet spectrum at 334 and 408 nm). This product can be purified by chromatography. The crude product can also be used for the next step without any preliminary purification.
11.4 g of 11,12-11',12'-bisdehydro-β-carotene were dissolved in 100 ml of petroleum ether (boiling range 80° to100°C), and the solution was hydrogenated under normal conditions after the addition of 0.5 ml of quinoline and 5 g of a lead-poisoned palladium catalyst. After the calculated amount of hydrogen had been absorbed, the catalyst was removed by filtration and the filtrate was extracted with dilute sulfuric acid to remove the quinoline. By concentrating the solution in the usual manner there was obtained 11,12- 11',12'-di-cis-carotene. The product was purified by recrystallization from benzene-alcohol. The purified product melts at 154°C; absorption maxima in the ultraviolet spectrum at 276, 334, 338, 401 and 405 nm. The isomerization was effected by heating the product for 10 hours at 90 to 100°C in high-boiling petroleum ether in a carbon dioxide atmosphere. The resulting and carotene melted at 180°C; ultraviolet absorption maxima at 452 and 480 nm.
Preparation of the intermediates for the above chemical synthesis are also described in US. Patent 2,917,539. The other patents cited below describe a fermentation route. US Patent 2,848,508 describes preparation from carrots.

brand name

BetaVit (BASF); Lucaratin (BASF); Solatene (Hoffmann-LaRoche).

Therapeutic Function

Vitamin A precursor, Sunscreen agent

安全性プロファイル

When heated to decomposition it emits acrid smoke and irritating fumes.

純化方法

It forms purple prisms when crystallised from *C6H6/MeOH and red rhombs from pet ether. Its solubility in hexane is 0.1% at 0o. It is oxygen sensitive and should be stored under N2 at -20o in the dark. It gives a deep blue colour with λmax at 590nm when mixed with SbCl3 in CHCl3. UV: (*C6H6) 429infl, max at 454 and 484nm. The principal peak at 454nm has 1cm 1% 2000. [Synthesis: Surmatis & Ofner J Org Chem 26 1171 1961; Milas et al. J Am Chem Soc 72 4844 1950.] β-Carotene is also purified by column chromatography (Al2O3 activity I-II). It is dissolved in pet ether/*C6H6 (10:1), applied to the column and eluted with pet ether/EtOH; the desired fraction is evaporated and the residue is recrystallised from *C6H6/MeOH (violet-red plates). [UV: Inhoffen et al. Justus Liebigs Ann Chem 570 54, 68 1950; Review: Fleming Selected Organic Synthesis (J Wiley, Lond) pp. 70-74 1973.] Alternatively it can be purified by chromatography on a magnesia column, thin layer of Kieselguhr or magnesia. Crystallise it from CS2/MeOH, Et2O/pet ether, acetone/pet ether or toluene/MeOH. Store it in the dark, under an inert atmosphere, at -20o. Recrystallise it also from 1:1 EtOH/CHCl3. [Bobrowski & Das J Phys Chem 89 5079 1985, Johnston & Scaiano J Am Chem Soc 1 0 8 2349 1986, Strain J Biol Chem 105 523 1934, Meth Biochem Anal 4 1 1957, Beilstein 5 II 638, 5 III 2453, 5 IV 2617.]

Properties and Applications

: yellow to orange.

β-カロテン 上流と下流の製品情報

原材料

準備製品


β-カロテン 生産企業

Global( 488)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
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7235-40-7(β-カロテン)キーワード:


  • 7235-40-7
  • SOLATENE
  • PROVITAMIN A1
  • PROVITAMIN A
  • TRANS-B-CAROTENE
  • TRANS-BETA-CAROTENE
  • (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene)
  • 1,1’-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-cyclohexen
  • 1,3,5,7,9,11,13,15,17-Octadecanonene,3,7,12,16-tetramethyl-1,18-cyclohex-1-ene,2,6,6-trimethyl-
  • 6-trimethyl-18-diyl)bis((all-e)-6
  • all-E-beta-Carotene
  • all-trans-beta-caroten
  • All-trans-beta-Carotene
  • beta-Carotene, all-trans-
  • BetaVit
  • C.I. 75130
  • c.i.75130
  • Carotaben
  • CAROTENE, beta
  • Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,1 8-diyl)bis*2,6,6-trimethyl-, (all-E)-
  • BETA-CAROTENE
  • BETA CAROTENE NATURAL
  • B-CAROTENE
  • CAROTENE TYPE II
  • CAROTENE TYPE I
  • CAROTENE, B-
  • Beta-caroten
  • BETA-CAROTENE, ~1600 U/MG
  • TRANS-B-CAROTENE, TYPE I, SYNTHETIC
  • B-CAROTENE TYPE II SYNTHETIC
  • Beta-Carotene,Crystalline
  • β-カロテン
  • C.I.フードオレンジ5
  • trans-β-カロテン
  • β,β-カロテン
  • (1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-テトラメチル-1,18-ビス(1,3,3-トリメチルシクロヘキセン-2-イル)-1,3,5,7,9,11,13,15,17-オクタデカノナエン
  • β-カロチン
  • all-trans-β-カロテン
  • βカロテン
  • Β-カロテン標準品
  • ベータカロチン
  • カロチン
  • プロビタミンA
  • Β‐カロテン標準品
  • カロテン, Β-
  • ベータカロテン
  • テルペン
  • テルペン (その他)
  • ビタミン
  • 抗酸化剤
  • 生化学
  • ビタミンA
  • 脂溶性ビタミン
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