Terutroban
|
|
|
- CAS番号.
- 165538-40-9
- 化学名:
- 别名:
- 英語名:
- Terutroban
- 英語别名:
- S18886;S 18886;Triplion;Terutroban;Terutroban >=95% (HPLC);Prostaglandin Receptor,S-18886,Terutroban,inhibit,S18886,S 18886,Inhibitor;(R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid;(R)-3-(6-((4-Chlorophenyl)sulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid;(6R)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid;3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDROPHTHALEN-1-YL]PROPANOIC ACID
- CBNumber:
- CB41508620
- 化学式:
- C20H22ClNO4S
- 分子量:
- 407.91
- MOL File:
- 165538-40-9.mol
|
Terutroban 物理性質
- 融点 :
- 189 - 192°C
- 沸点 :
- 591.8±60.0 °C(Predicted)
- 比重(密度) :
- 1.38±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- クロロホルム (マイルド、超音波処理)、DMSO (マイルド)、メタノール (マイルド、超音波処理)
- 酸解離定数(Pka):
- 4.60±0.10(Predicted)
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
Terutroban 価格
もっと(1)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC5568 |
S 18886 |
165538-40-9 |
10mg |
￥46000 |
2024-03-01 |
購入 |
Terutroban 化学特性,用途語,生産方法
説明
The lipid mediator thromboxane A
2 (TXA
2) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA
2 are mediated by its specific G protein coupled-receptor, referred to as the TXA
2 receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC
50 value of 16.4 nM. It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis. S18886 is the active isomer of the potent TP receptor antagonist, S18204. Antagonists of TP receptors have advantages over aspirin as they not only block the effect of TXA
2 on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.
使用
Terutroban functions as an anti-platelets therapies for patients with ischemic stroke or transient ischemic attack. Also used in the research process of anti-coagulant drugs in preventing and controlling cerebral stroke.
Terutroban 上流と下流の製品情報
原材料
準備製品
Terutroban 生産企業
Global( 65)Suppliers
- 165538-40-9
- Terutroban
- S 18886
- S18886
- 3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-1-YL]PROPANOIC ACID
- (R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
- Triplion
- (6R)-6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
- 3-[(6R)-6-[(4-CHLOROPHENYL)SULFONYLAMINO]-2-METHYL-5,6,7,8-TETRAHYDROPHTHALEN-1-YL]PROPANOIC ACID
- 1-Naphthalenepropanoic acid, 6-[[(4-chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-, (6R)-
- Terutroban >=95% (HPLC)
- (R)-3-(6-((4-Chlorophenyl)sulfonamido)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid
- Prostaglandin Receptor,S-18886,Terutroban,inhibit,S18886,S 18886,Inhibitor