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テラプレビル-D4

テラプレビル-D4 化学構造式
402957-28-2
CAS番号.
402957-28-2
化学名:
テラプレビル-D4
别名:
テラプレビル-D4;テラプレビル;テラプレビル (JAN)
英語化学名:
Telaprevir
英語别名:
CS-61;VX-950;MP-424;CS-1855;LY-570310;Telaprevir;tellaprevir;Telaprevir-d4;Telaprevir, >=98%;TELAPREVIR; VX-950
CBNumber:
CB41519837
化学式:
C36H53N7O6
分子量:
679.85
MOL File:
402957-28-2.mol

テラプレビル-D4 物理性質

比重(密度) :
1.25
酸解離定数(Pka):
11.84±0.20(Predicted)

安全性情報

Sフレーズ  24/25
HSコード  29339900

テラプレビル-D4 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCT015652 テラプレビル-d4
Telaprevir-d4
402957-28-2 0.25mg ¥112500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01MAS122741 テラプレビル
Telaprevir
402957-28-2 1g ¥2613600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCT015652 テラプレビル-d4
Telaprevir-d4
402957-28-2 1mg ¥437500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCT015652 テラプレビル-d4
Telaprevir-d4
402957-28-2 5mg ¥1312500 2018-12-26 購入

テラプレビル-D4 化学特性,用途語,生産方法

効能

抗ウイルス薬, プロテアーゼ阻害薬

説明

The hepatitis C virus (HCV) protease inhibitor telaprevir (VX-950, MP- 424,LY-570310) was approved by the U.S. FDA in May 2011 for the treatment of genotype 1 chronic HCV infection in adult patients in combination with peginterferon alfa and ribavirin (PR). Telaprevir and boceprevir (vide supra) are the first two HCV protease inhibitors to be approved for treatment of HCV infection. Telaprevir is a HCV NS3-4A protease inhibitor that exerts its antiviral effect by blocking the release of nonstructural viral proteins from a polyprotein precursor. Telaprevir is a potent inhibitor of the protease (IC50=10 nM) and is active in cell culture (HCV 1b replicon assay, EC50=354 nM). Telaprevir was identified from efforts to truncate a decamer peptide inhibitor derived from the natural substrate NS5A-5B and was guided by structure-based design. The ketoamide group of telaprevir forms a covalent, reversible bond with the active site serine hydroxyl of the protease and compensates for the loss of affinity resulting from truncation of the peptide. Despite the presence of the reactive keto-amide group, telaprevir is >500-fold less potent against other serine proteases. Synthesis of the key octahydrocyclopenta[c]pyrrole-1-carboxylic acid fragment of telaprevir is achieved by a-deprotonation of Boc-protected 3-azabicyclo[3.3.0]nonane followed by reaction with CO2 and resolution of the racemic acid. Alternatively, deprotonation is carried out in the presence of a chiral amine to give the enantiomerically enriched acid.

化学的特性

Telaprevir is White Solid

Originator

Eli Lilly (United States)

使用

Telaprevir is a peptidomimetic inhibitor of hepatitis C virus protease.

使用

Labeled Telaprevir, intended for use as an internal standard for the quantification of Telaprevir by GC- or LC-mass spectrometry.

使用

A labelled peptidomimetic inhibitor of hepatitis C virus protease.

定義

ChEBI: An oligopeptide consisting of N-(pyrazin-2-ylcarbonyl)cyclohexylalanyl, 3-methylvalyl, octahydrocyclopenta[c]pyrrole-1-carboxy, and 3-amino-N-cyclopropyl-2-oxohexanamide residues joined in sequence. Used f r treatment of chronic hepatitis C virus genotype 1 infection.

brand name

Incivek

テラプレビル-D4 上流と下流の製品情報

原材料

準備製品


テラプレビル-D4 生産企業

Global( 199)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 921 58
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3252 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58

402957-28-2(テラプレビル-D4)キーワード:


  • 402957-28-2
  • Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N
  • CS-61
  • VX950;TELAPREVIR;VX 950
  • Telaprevir (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide
  • Telaprevir-d4
  • Telaprevir, >=98%
  • tellaprevir
  • (1S,3aR,6aS)-N-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
  • Cyclopenta(c)pyrrole-1-carboxamide
  • Telaprevir, 98%, Hepatitis c virus (HCV)NS3-4Aserine protease inhibitors
  • Telaprevir intermediates
  • Cyclopenta(c)pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydro-, (1S,3aR,6aS)-
  • VX-950
  • VX-950 (Teleprevir)
  • (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide
  • Telaprevir
  • (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-6-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-octahydrocyclopenta[c]pyrrole-1-carboxamide VX-950
  • TELAPREVIR; VX-950
  • VX-950(Telaprevir)
  • (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxaMido)acetaMido)-3,3-diMethylbutanoyl)-N-((S)-1-(cyclopropylaMino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxaMide
  • (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxaMido)acetaMido)-3,3-diMethylbutanoyl)-N-((R)-1-(cyclopropylaMino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxaMid
  • telaprevir (VX-950) (Incivek)
  • LY-570310
  • MP-424
  • (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta[c]pyrrole-1-carboxamide Telaprevir(VX950)
  • CS-1855
  • (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide
  • テラプレビル-D4
  • テラプレビル
  • テラプレビル (JAN)
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