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[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2)

[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 化学構造式
58-58-2
CAS番号.
58-58-2
化学名:
[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2)
别名:
塩酸プロマイシン;プロマイシン二塩酸塩;プロマイシン塩酸塩;[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2);ピューロマイシン二塩酸塩;ピューロマイシン二塩酸塩水和物;ピューロマイシン, 二塩酸塩, 結晶;ピューロマイシン 二塩酸塩;ピューロマイシン 二塩酸塩 STREPTOMYCES ALBONIGER由来
英語化学名:
PUROMYCIN DIHYDROCHLORIDE
英語别名:
pdh;l-2hc;PUROMYCIN;PUROMYCIN 2HCL;-9H-purin-9-yl);-5-(6-(dimethylamino);tetrahydrofuran-3-yl);puromycinhydrochloride;stylomycinhydrochloride;PUROMYCINDIHYROCHLORIDE
CBNumber:
CB4152905
化学式:
C22H31Cl2N7O5
分子量:
544.43
MOL File:
58-58-2.mol

[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 物理性質

融点 :
168-170℃
貯蔵温度 :
−20°C
溶解性:
H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.)
外見 :
solution
色:
yellow-white
水溶解度 :
Soluble in water
Merck :
14,7943
BRN :
3853613
安定性::
Stable. Heat sensitive. Incompatible with strong oxidizing agents.
InChIKey:
MKSVFGKWZLUTTO-NGOAXYITSA-N
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-40
Sフレーズ  24/25
RIDADR  3249
WGK Germany  3
RTECS 番号 AU7355000
3-8-10
国連危険物分類  6.1(b)
容器等級  III
HSコード  29419090
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P330 口をすすぐこと。

[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 価格 もっと(27)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0116-2315 ピューロマイシン二塩酸塩 96.0+% (HPLC)
Puromycin Dihydrochloride 96.0+% (HPLC)
58-58-2 25mg ¥6800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01W0116-2315 ピューロマイシン二塩酸塩 96.0+% (HPLC)
Puromycin Dihydrochloride 96.0+% (HPLC)
58-58-2 100mg ¥22800 2018-12-26 購入
東京化成工業 P2311 ピューロマイシン二塩酸塩 >97.0%(HPLC)
Puromycin Dihydrochloride >97.0%(HPLC)
58-58-2 25mg ¥7500 2018-12-04 購入
関東化学株式会社(KANTO) 22742-1A ピューロマイシン二塩酸塩水和物 99%
Puromycin dihydrochloride hydrate 99%
58-58-2 10mg ¥6800 2018-12-13 購入
Sigma-Aldrich Japan P7255 ピューロマイシン 二塩酸塩 Streptomyces alboniger由来 ≥98% (HPLC), powder
Puromycin dihydrochloride from Streptomyces alboniger ≥98% (HPLC), powder
58-58-2 25mg ¥17400 2018-12-25 購入

[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 化学特性,用途語,生産方法

外観

白色〜うすい褐色, 結晶〜粉末

溶解性

メタノール及び水に溶ける。

化学的特性

white powder

使用

Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.

使用

antibacterial

使用

Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

使用

Puromycin dihydrochloride is a salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

使用

An aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene.

使用

Research tool for studying protein synthesis; cell line selection agent in gene transfer experiments.

一般的な説明

White powder.

空気と水の反応

Water soluble.

反応プロフィール

PUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. . Behaves as a very weak acid in solution.

火災危険

Flash point data for PUROMYCIN DIHYDROCHLORIDE are not available, but PUROMYCIN DIHYDROCHLORIDE is probably combustible.

純化方法

Puromycin dihydrochloride is purified by recrystallisation from H2O. The free base, [58-60-6] M 294.3, has m 175.5-177o (172-173o) (from H2O). The sulfate has m 180-187o dec (from H2O), and the picrate monohydrate has m 146-149o (from H2O). [Baker et al. J Am Chem Soc 77 1 1955, Fryth et al. J Am Chem Soc 80 3736 1958.] It is an inhibitor of aminopeptidase and terminates protein synthesis [Reboud et al. Biochemistry 20 5281 1981]. [Beilstein 26 III/IV 3704.]

使用上の注意

不活性ガス封入

[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 上流と下流の製品情報

原材料

準備製品


[3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2) 生産企業

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58-58-2([3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2))キーワード:


  • 58-58-2
  • Puromycin dihydrochloride hydrate,99%
  • 3'-[[12-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL
  • 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE
  • 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL
  • 3'-(A-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE
  • 3'-(A-AMINO-P-METHOXY-HYDOCINNAMAMIDO)-3'-DEXOY-N,N-DIMETHYLADENOSINE 2HCL
  • 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMINO-3'-DEOXY-N,N-DIMETHY-ADENOSINE) 2HCL
  • 3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMIDO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE) 2HCL
  • 3'-[ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE
  • 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE, 2HCL
  • 3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMADIO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE
  • 3’-(alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyl-adenosin
  • adenosine,3’-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3’-deoxy-n,n-dim
  • dihydrochloride,(s)-ethyl
  • PUROMYCIN Dihydrochloride Dihydrate 96%
  • PUROMYCIN, CELL CULTURE TESTED
  • Puromycin, 3-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochloride
  • Puromycin hydrate dihydrochloride
  • PuroMycin dihydrochloride hydrate, 99% 10MG
  • PuroMycin dihydrochlorid
  • Puromycin dihydrochloride (animal free)
  • StyloMycin dihydrochloride, CL 13900 dihydrochloride, CL16536, NSC 3055, P638 dihydrochloride.
  • 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine,hydrochloride (1:2)
  • Puromycin 2HCl (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
  • Puromycin dihydrochloride (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
  • Puromycin 2hydrochloride
  • -2-Amino-N-((2S,3S,4R,5R)
  • -4-hydroxy-2-(hydroxymethyl)
  • -5-(6-(dimethylamino)
  • -9H-purin-9-yl)
  • 塩酸プロマイシン
  • プロマイシン二塩酸塩
  • プロマイシン塩酸塩
  • [3'-[[(S)-2-アミノ-3-(p-メトキシフェニル)プロピオニル]アミノ]-3'-デオキシ-N,N-ジメチルアデノシン]/塩酸塩,(1:2)
  • ピューロマイシン二塩酸塩
  • ピューロマイシン二塩酸塩水和物
  • ピューロマイシン, 二塩酸塩, 結晶
  • ピューロマイシン 二塩酸塩
  • ピューロマイシン 二塩酸塩 STREPTOMYCES ALBONIGER由来
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