1,8-ジヒドロキシアントロン 化学特性,用途語,生産方法
外観
わずかにうすい黄色～橙色、結晶性粉末～粉末
効能
乾癬治療薬
説明
Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome
c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM. Anthralin (0.25 μM) decreases the expression of β-defensin-2 and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B
4 (LTB
4; ) production, stimulated by the calcium ionophore A23187 , from human neutrophils (IC
50 = 7 μM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.
化学的特性
Yellow Crystalline Solid
使用
Antipsoriatic
適応症
Anthralin (Anthra-Derm) is a potent reducing agent
whose mechanism of action is unknown. It is approved
for the treatment of psoriasis and also may be helpful in
alopecia areata. The major toxicities are discoloration
of skin, hair, and nails and irritant dermatitis.
定義
ChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.
一般的な説明
Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.
空気と水の反応
Unstable in air when in alkaline solution. Insoluble in water.
反応プロフィール
ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture .
危険性
Very irritating. Do not use on scalp or near eyes.
火災危険
Flash point data are not available for ANTHRALIN; however, ANTHRALIN is probably combustible.
副作用
Anthralin's side effects include pruritus, erythema, scaling,
folliculitis, and lymphadenopathy. Staining of skin and clothes can also be an issue.
1,8-ジヒドロキシアントロン 上流と下流の製品情報
原材料
準備製品