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ポビドン

ポビドン 化学構造式
9003-39-8
CAS番号.
9003-39-8
化学名:
ポビドン
别名:
ポリビニルピロリドン (不溶性);ポリビニルピロリドン K 15 (粘度平均分子量10,000);ポリビニルピロリドン K 30 (粘度平均分子量40,000);ポリビニルピロリドン K 60 (約35%水溶液);ポリビニルピロリドン K 90 (粘度平均分子量630,000);ポリビニルピロリドン;ポリビニルピロリジノン;ポリビニルピロリジノン(K12);ポリビニルピロリジノン(K16-18);ポリビニルピロリジノン(K85-95);ポビドン;ポリビドン;PVP;ポリビニルピロリドン K-15;ポリビニルピロリドン K-30;ポリビニルピロリドン K-90;ポリ(N-ビニルピロリドン);ポリビニルピロリドン (不溶性);ポリビニルピロリドン K 15 (平均分子量10,000);ポリビニルピロリドン K 30 (平均分子量40,000)
英語化学名:
Polyvinylpyrrolidone
英語别名:
k25;k60;POP;PVP;k115;pvp2;pvp3;pvp4;pvp5;pvp6
CBNumber:
CB4209342
化学式:
CH4
分子量:
16.04246
MOL File:
9003-39-8.mol

ポビドン 物理性質

融点 :
~165 °C (dec.)(lit.)
比重(密度) :
1,69 g/cm3
貯蔵温度 :
Store at RT.
溶解性:
H2O: soluble100mg/mL
外見 :
powder
色:
White to yellow-white
PH:
3.0-5.0
水溶解度 :
Soluble in water.
Sensitive :
Hygroscopic
Merck :
14,7697
安定性::
Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
EPAの化学物質情報:
2-Pyrrolidinone, 1-ethenyl-, homopolymer(9003-39-8)

安全性情報

Sフレーズ  22-24/25
WGK Germany  1
RTECS 番号 TR8370000
自然発火温度 440 °C
TSCA  Yes
HSコード  39059990
有毒物質データの 9003-39-8(Hazardous Substances Data)
毒性 LD50 orally in Rabbit: > 2000 mg/kg
化審法 (6)-1007, (6)-1048

ポビドン 価格 もっと(104)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00016992 ポビドン
Povidone
9003-39-8 100mg ¥16800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00016992 ポビドン
Povidone
9003-39-8 1g ¥26600 2018-12-26 購入
東京化成工業 P0471 ポリビニルピロリドン K 15 (平均分子量10000)
Polyvinylpyrrolidone K 15 Average Molecular Wt. 10000
9003-39-8 25g ¥2400 2018-12-04 購入
東京化成工業 P0471 ポリビニルピロリドン K 15 (平均分子量10000)
Polyvinylpyrrolidone K 15 Average Molecular Wt. 10000
9003-39-8 100g ¥5400 2018-12-04 購入
関東化学株式会社(KANTO) 22746-1A ポリビニルピロリジノン(K16‐18)
Polyvinylpyrrolidinone (K16‐18), average M.W.8,000
9003-39-8 500g ¥14600 2018-12-13 購入

ポビドン MSDS


Polyvinylpyrrolidone

ポビドン 化学特性,用途語,生産方法

外観

白色〜わずかにうすい黄色, 結晶性粉末〜粉末

定義

本品は、1-ビニル-2-ピロリドン(VP)の重合体であり、次の化学式で表される。

溶解性

水及びエタノールに溶けやすく、アセトンに溶けにくい。

化粧品の成分用途

ヘアスタイリング剤、非活性剤系分散剤、結合剤、皮膜形成剤、乳化安定剤

効能

撒布剤, 懸濁剤

主な用途/役割

1,4-ブタンジオールとアンモニアを原料として生成したn-ビニル-2-ピロリドンを重合させたもの。紙用接着剤原料、エマルション系接着剤の増粘剤として使用される。

化学的特性

Hygroscopic, white or yellowish-white powder or flakes.

化学的特性

Povidone occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder. Povidones with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres. Povidone K-90 and higher K-value povidones are manufactured by drum drying and occur as plates.

使用

suitable for gene delivery

定義

ChEBI: A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.

調製方法

Povidone is manufactured by the Reppe process. Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone. Pyrrolidone is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure. The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.

brand name

Kollidon CL (BASF); Kollidon CLM (BASF); Polyplasdone (International Specialty Products);Acu-dyne;Adapettes;Adsorbobase;Adsovbotear;Agent at 717;Albigen a;Aldacol q;Amiorel eritro;Amyderm s;Andrestrac 2-10;Anexa;B 7509;Betaisod;Bridine;Clinidine;Final step;Frepp/sepp;Ganex p 804;Ga-pvp-101;Gyno-bidex;Isoplasma;Jodoplex;K 115;Kollidon 17;Kollidon 25;Kollidon 30;Kollidon 90;Kollidon ce 50/50;Kollidon k 25;Kollidon k 30;Luviskol k 17;Luviskol k 25;Luviskol k 30;Luviskol k 90;Luvisteol;Medicort;Molycu;Mundidon;Neojodin;Oftan flurekain;Peragal st;Periston-n-toxobin;Pevidine;Plasmadone;Plasmoid;Plassint;Podiodine;Polyclar at;Polyclar h;Polyclar l;Polyplasdone xl;Polyvidone-escupient;Polyvinyl pyrrolidone;Povadyne;Povidone k 29-32;Pvp 50;Pvp0;Pvp-k 15;Pvp-k 25;Pvp-k 30;Pvp-k 60;Pvp-k 90;Pvp-macrose;Pvp-macrox;Rocmuth;Sd 13;Soft-care;Tears plus;Venostasin retard;Vetedine;Yodiplexin.

世界保健機関(WHO)

Polyvidone, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent. Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions. This has led to the withdrawal of polyvidone from such preparations in some countries. Polyvidone was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued. However, it remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.

一般的な説明

White powder. Compatible with a wide range of hydrophilic and hydrophobic resins.

空気と水の反応

Hygroscopic. Water soluble.

反応プロフィール

Polyvinylpyrrolidone is a polymeric material and probably has low reactivity. Polyvinylpyrrolidone reacts as a weak base.

危険性

Questionable carcinogen.

健康ハザード

SYMPTOMS: Polyvinylpyrrolidone may cause interstitial fibrosis in the lungs. Lesions regress when patient is no longer being exposed to the compound.

火災危険

Flash point data for Polyvinylpyrrolidone are not available, but Polyvinylpyrrolidone is probably non-flammable.

応用例(製薬)

Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms. In tableting, povidone solutions are used as binders in wet-granulation processes.Povidone is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions. Povidone is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms. Povidone solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Povidone is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions. The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free povidone are available and have been used in parenteral formulations;

接触アレルゲン

Polyvinylpyrrolidone is widely used as is in cosmetics such as hair care products and in medical products. It acts as iodophor in iodine-polyvinylpyrrolidone. PVP is an irritant and has been claimed as the allergen in some cases of dermatitis from iodine-polyvinylpyrrolidone (although iodine is more likely the hapten). It may cause type I contact urticaria or anaphylaxis.

安全性プロファイル

Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen. When heated to decomposition it emits toxic fumes of NOx.

安全性

Povidone has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Povidone is widely used as an excipient, particularly in oral tablets and solutions. When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.Povidone additionally has no irritant effect on the skin and causes no sensitization. exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.
(mouse, IP): 12 g/kg

貯蔵

Povidone darkens to some extent on heating at 150°C, with a reduction in aqueous solubility. It is stable to a short cycle of heat exposure around 110–130°C; steam sterilization of an aqueous solution does not alter its properties. Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Povidone may be stored under ordinary conditions without undergoing decomposition or degradation. However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.

純化方法

Purify it by dialysis, and freeze-drying. Also by precipitation from CHCl3 solution by pouring into ether. Dry it in a vacuum over P2O5. For the crosslinked polymer purification is by boiling for 10minutes in 10% HCl and then washing with glass-distilled water until free from Cl ions. Finally, Cl ions are removed more readily by neutralising with KOH and continued washing.

不和合性

Povidone is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals. It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18. The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.

規制状況(Regulatory Status)

Accepted for use in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IM and IV injections; ophthalmic preparations; oral capsules, drops, granules, suspensions, and tablets; sublingual tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ポビドン 上流と下流の製品情報

原材料

準備製品


ポビドン 生産企業

Global( 356)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 272 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2839 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58

9003-39-8(ポビドン)キーワード:


  • 9003-39-8
  • Polyvinylpyrrolidone (K15) BioChemica
  • Polyvinylpyrrolidone Manufacturer
  • 143rp
  • 1-ethenyl-2-pyrrolidinonepolymers
  • 1-ethenyl-2-pyrrolidinonhomopolymer
  • 1-vinyl-2-pyrrolidinonpolymers
  • 2-pyrrolidinone,1-ethenyl,homopolymer
  • 2-Pyrrolidinone,1-ethenyl-,homopolymer
  • agentat717
  • agrimer
  • albigena
  • aldacolq
  • at717
  • bolinan
  • ganexp804
  • ganexp-804
  • hemodesis
  • hemodez
  • k115
  • k115(polyamide)
  • k25
  • k25(polymer)
  • k25[polymer]
  • k30(polymer)
  • k30[polymer]
  • k60
  • k60(polymer)
  • kollidon
  • kollidon17
  • kollidon25
  • ポリビニルピロリドン (不溶性)
  • ポリビニルピロリドン K 15 (粘度平均分子量10,000)
  • ポリビニルピロリドン K 30 (粘度平均分子量40,000)
  • ポリビニルピロリドン K 60 (約35%水溶液)
  • ポリビニルピロリドン K 90 (粘度平均分子量630,000)
  • ポリビニルピロリドン
  • ポリビニルピロリジノン
  • ポリビニルピロリジノン(K12)
  • ポリビニルピロリジノン(K16-18)
  • ポリビニルピロリジノン(K85-95)
  • ポビドン
  • ポリビドン
  • PVP
  • ポリビニルピロリドン K-15
  • ポリビニルピロリドン K-30
  • ポリビニルピロリドン K-90
  • ポリ(N-ビニルピロリドン)
  • ポリビニルピロリドン (不溶性)
  • ポリビニルピロリドン K 15 (平均分子量10,000)
  • ポリビニルピロリドン K 30 (平均分子量40,000)
  • ポリビニルピロリドン K 60 (平均分子量160,000) (約35%水溶液)
  • ポリビニルピロリドン K 90 (平均分子量360,000)
  • ポリビニルピロリドン K 15 (平均分子量10000)
  • ポリビニルピロリドン K 30 (平均分子量40000)
  • ポリビニルピロリドン K 90 (平均分子量360000)
  • ポリビニルピロリジノン(K16‐18)
  • ポリビニルピロリジノン(K85‐95)
  • ポリビニルピロリドン K-15 (PVP K-15)
  • ポリビニルピロリドン K-30(PVP K-30)
  • ポリビニルピロリドン K-90(PVP K-90)
  • ポリビニルピロリドンK-15
  • ポリビニルピロリドンK-30
  • ポリビニルピロリドンK-90
  • ポリビニルピロリドン K 25
  • ポリビニルピロリドン K 30
  • ポリクラールVT
  • クロスポビドン
  • ポリビニルピロリドンK30
  • ポリビニルピロリドンK90
  • ポリ(ビニルポリピロリドン)
  • ポリビニルピロリドン 溶液
  • ポビドン (JP17)
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