MI-3 (Menin-MLL Inhibitor)

 化学構造式
1271738-59-0
CAS番号.
1271738-59-0
化学名:
别名:
英語名:
MI-3 (Menin-MLL Inhibitor)
英語别名:
MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
CBNumber:
CB42624233
化学式:
C18H25N5S2
分子量:
375.55
MOL File:
1271738-59-0.mol

MI-3 (Menin-MLL Inhibitor) 物理性質

沸点 :
527.9±60.0 °C(Predicted)
比重(密度) :
1.36±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
外見 :
Powder
酸解離定数(Pka):
9.59±0.40(Predicted)
色:
Light yellow to yellow

安全性情報

MI-3 (Menin-MLL Inhibitor) 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

MI-3 (Menin-MLL Inhibitor) 化学特性,用途語,生産方法

説明

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

使用

MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.

MI-3 (Menin-MLL Inhibitor) 上流と下流の製品情報

原材料

準備製品


MI-3 (Menin-MLL Inhibitor) 生産企業

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1271738-59-0()キーワード:


  • 1271738-59-0
  • MI-3
  • Menin-MLL inhibitor 3
  • Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
  • 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
  • MI-3 (Menin-MLL Inhibitor)
  • 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3
  • 5-dihydro-5
  • 5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
  • MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL)
  • CS-1809
  • MI-3 (Menin-MLL Inhibitor) USP/EP/BP
  • MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor
  • 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
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