AZD7545
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- CAS番号.
- 252017-04-2
- 化学名:
- 别名:
- 英語名:
- AZD7545
- 英語别名:
- AZD7545;AZD4575;CS-1842;AZD-7547;AZD 7547;AZD7547;AZD7545/AZD-7545;PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545;(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide;(2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
- CBNumber:
- CB42627360
- 化学式:
- C19H18ClF3N2O5S
- 分子量:
- 478.87
- MOL File:
- 252017-04-2.mol
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AZD7545 物理性質
- 沸点 :
- 683.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.473±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- ≥21.85 mg/mL in DMSO; insoluble in H2O; ≥15.63 mg/mL in EtOH with ultrasonic
- 外見 :
- solid
- 酸解離定数(Pka):
- 10.39±0.29(Predicted)
- 色:
- White to off-white
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
AZD7545 価格
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製品説明 |
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AZD7545 化学特性,用途語,生産方法
説明
AZD 7545 is an inhibitor of pyruvate dehydrogenase (PDH) kinases (PDKs), resulting in an increase in PDH activity with an EC
50 value of 5.2 nM for PDK2. It less potently inhibits PDK1 and PDK3 (IC
50s = 87 and 600 nM, respectively). AZD 7545 stimulates pyruvate oxidation in rat hepatocytes (EC
50 = 105 nM) and significantly elevates muscle PDH activity in obese Zucker rats. It elevates postprandial glucose levels and improves the 24 hour glucose profile in obese, insulin-resistant rats, compared with lean counterparts.
AZD7545 上流と下流の製品情報
原材料
準備製品
AZD7545 生産企業
Global( 77)Suppliers
252017-04-2()キーワード:
- 252017-04-2
- AZD7545
- AZD7545/AZD-7545
- 4-[[3-Chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethylbenzamide
- (R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide
- Benzamide, 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-
- AZD7545,(R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide
- AZD 7547;AZD7547
- (2,4-Dihydroxy-5-isopropylphenyl)5-[(4-methyl-1-piperazinyl)meth yl]-1,3-dihydro-2H-isoindol-2-ylmethanone, 99%
- AZD4575
- AZD-7547
- CS-1842
- PDH kinase,inhibit,AZD7545,PDHK,AZD 7545,Pyruvate dehydrogenase kinase,Inhibitor,AZD-7545