ジイソブチルアミン 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
溶解性
エタノール及びアセトンに極めて溶けやすく、水に極めて溶けにくい。
用途
医薬品、塩素化炭化水素の安定剤
用途
樹脂原料、殺虫剤
化学的特性
The chemical reactivity of diisobutylamine is similar to other aliphatic amines and
is governed by the unshared electron pair on the nitrogen atom. It is a strong base
tending to form salts with acids. As with other secondary amines, diisobutylamine
can be nitrosated, especially under acidic conditions, by nitrite ion or by nitrogen
oxides from the air to form the carcinogenic and mutagenic N-nitrosodiisobutylamine
(Olah et al 1975).
使用
Diisobutylamine was used to study the effect of achiral amine on hydrogenation of ethyl pyruvate over cinchonidine-Pt/Al2O3 catalyst system. Diisobutylamine is the principal starting material for the herbicide Butylate (Zeneca).
調製方法
Diisobutylamine can be produced by the reaction of ammonia and butanol over a
dehydration catalyst at high temperature and pressure (Hawley 1977). Alternatively,
ammonia, butanol, and hydrogen can be passed over a dehydrogenation
catalyst. In 1976, 18,000 tons of diisobutylamine were produced (Schweizer et al
1978). Diisobutylamine is also naturally present in foods and soil.
As with other secondary amines, diisobutylamine can be nitrosated to form the
highly toxic (Olah 1975) N-nitrosodiisobutylamine (Guttenplan 1987; Vlasenko et
al 1981; Spiegeholder et al 1978). Thus, nitrosation of commercial preparations of
diisobutylamine occurs on standing, presumably by reaction with nitrogen oxides
in the air (Spiegelhalder et al 1978) and N-nitrosodiisobutylamine has been found
in various fishery products (Kawabata et al 1974) and other foods (Osborne 1972;
Telling 1972).
一般的な説明
Diisobutylamine appears as a clear colorless liquid with an ammonia-like odor. Insoluble in water and less dense than water. Hence floats on water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
空気と水の反応
Highly flammable. Sensitive to heat and air. Insoluble in water.
反応プロフィール
Diisobutylamine can react vigorously with oxidizing materials . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
健康ハザード
Diisobutylamine is a relatively strong base and is therefore irritating to the eyes,
respiratory tract, and skin. Inhalation of vapors can result in pulmonary edema
following prolonged exposure. Ingestion of liquid can cause severe burning of the
esophagus.
工業用途
Diisobutylamine is used as a chemical intermediate in the manufacture of several
agricultural and pharmaceutical products.
安全性プロファイル
Poison by ingestion. A
dangerous fire hazard when exposed to heator flame; can react vigorously with oxidizing
materials. To fight fire, use alcohol foam,
CO2, dry chemical. When heated to
decomposition it emits toxic fumes of Nox
代謝
There is little information available on the metabolism of diisobutylamine.
ジイソブチルアミン 上流と下流の製品情報
原材料
準備製品