OICR-9429
|
|
- CAS番号.
- 1801787-56-3
- 化学名:
- 别名:
- 英語名:
- OICR-9429
- 英語别名:
- CS-2362;OICR-9429;OICR-9429 (OICR9429;6-hydroxy-N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-4-(trifluoromethyl)nicotinamide;N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide;N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide;N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide;3-Pyridinecarboxamide, 1,6-dihydro-N-[4-(4-methyl-1-piperazinyl)-3'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-yl]-6-oxo-4-(trifluoromethyl)-;OICR9429,pancreatic,Histone Methyltransferase,MLL,inhibit,OICR-9429,colon,prostate cance,bladder cancer (BCa),Inhibitor,WD repeat domain 5 (WDR5),Apoptosis,leukaemia,H3K4
- CBNumber:
- CB43133471
- 化学式:
- C29H32F3N5O3
- 分子量:
- 555.59
- MOL File:
- 1801787-56-3.mol
|
OICR-9429 物理性質
- 沸点 :
- 693.0±55.0 °C(Predicted)
- 比重(密度) :
- 1.325±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- insoluble in EtOH; insoluble in H2O; ≥21.52 mg/mL in DMSO
- 酸解離定数(Pka):
- 8.84±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 白から薄茶色
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
|
注意喚起語 |
|
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
|
注意書き |
P264 |
取扱い後は皮膚をよく洗うこと。 |
P264 |
取扱い後は手や顔をよく洗うこと。 |
P302+P352 |
皮膚に付着した場合:多量の水と石鹸で洗うこと。 |
P321 |
特別な処置が必要である(このラベルの... を見よ)。 |
P332+P313 |
皮膚刺激が生じた場合:医師の診断/手当てを受けるこ と。 |
|
OICR-9429 価格
もっと(4)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5267 |
OICR 9429 |
1801787-56-3 |
10mg |
¥76000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5267 |
OICR 9429 |
1801787-56-3 |
50mg |
¥310000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML1209 |
≥98% (HPLC)
OICR-9429 ≥98% (HPLC) |
1801787-56-3 |
5mg |
¥33400 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML1209 |
≥98% (HPLC)
OICR-9429 ≥98% (HPLC) |
1801787-56-3 |
25mg |
¥112000 |
2021-03-23 |
購入 |
OICR-9429 化学特性,用途語,生産方法
使用
OICR-9429 is a chemical probe which inhibits the interaction of WDR5 (WD-repeat Protein 5) with peptide regions of MLL and Histone 3 with high selectivity. WDR5 is a part of the mixed-lineage leukemia (MLL) transferase complex that targets histone 3.
Biochem/physiol Actions
OICR-9429 is a cell penetrant, potent and selective antagonist of the interaction of WDR5 (WD repeat domain 5) with peptide regions of MLL and Histone 3 that potently binds to WDR5. OICR-9429 inhibits the interaction of WDR5 with MLL1 and RbBP5 in cells. For full characterization details, please see OICR-9429 on the Structural Genomics Consortium (SGC) website.OICR-0547 is the negative control for the active probe, OICR-9429. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
参考文献
[1] FLORIAN GREBIEN. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia[J]. Nature chemical biology, 2015, 11 8: 571-578. DOI:
10.1038/nchembio.1859.
[2] DONG A, DOMBROVSKI L, WALKER J, et al. Crystal structure of human WDR5 in complex with compound OICR-9429[C]. 2014: 0. DOI:
10.2210/pdb4ql1/pdb.
[3] MATTH?US GETLIK. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)[J]. Journal of Medicinal Chemistry, 2016, 59 6: 2478-2496. DOI:
10.1021/acs.jmedchem.5b01630.
OICR-9429 上流と下流の製品情報
原材料
準備製品
OICR-9429 生産企業
Global( 86)Suppliers
- 1801787-56-3
- N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
- 6-hydroxy-N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-4-(trifluoromethyl)nicotinamide
- CS-2362
- OICR-9429 (OICR9429
- N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
- 3-Pyridinecarboxamide, 1,6-dihydro-N-[4-(4-methyl-1-piperazinyl)-3'-(4-morpholinylmethyl)[1,1'-biphenyl]-3-yl]-6-oxo-4-(trifluoromethyl)-
- N-[2-(4-methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide
- OICR9429,pancreatic,Histone Methyltransferase,MLL,inhibit,OICR-9429,colon,prostate cance,bladder cancer (BCa),Inhibitor,WD repeat domain 5 (WDR5),Apoptosis,leukaemia,H3K4
- OICR-9429