デスオキシコルトン 化学特性,用途語,生産方法
解説
21-hydroxypregn-4-ene-3,20-dione．C21H30O3(330.46)．コルテクソン(cortexone)，ライヒシュタインの物質Qともいう．副じん皮質ホルモンの一つ．副腎皮質から単離される．また，プロゲステロンの微生物酸化で得られる．一方，プレグネノロンより合成される．白色の結晶．融点141～142 ℃．[α]20D＋173.6°(ジオキサン)．UVλmax 240 nm(log ε 412)．有機溶媒に可溶．ミネラルコルチコイド作用(塩分濃度調節作用)が強く，グルココルチコイド作用(糖代謝促進作用)はきわめて弱い．エステル体がアジソン氏病，副腎不全，ショックなどに使用される．[CAS 64-85-7]
"
森北出版「化学辞典（第2版）
効能
塩類代謝調節薬, ミネラルコルチコイド受容体作動薬
化学的特性
white to creamy-white crystalline powder
使用
A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).
定義
ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.
一般的な説明
11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution
? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.
危険性
Toxic.
作用機序
Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion
of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity.
This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity
and work capability are increased. It is used for an insufficiency of function of the adrenal
cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.
純化方法
Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]
デスオキシコルトン 上流と下流の製品情報
原材料
準備製品