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メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル

メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 化学構造式
1563-66-2
CAS番号.
1563-66-2
化学名:
メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル
别名:
フラダン3G;カルボフラン;フラダン75WP;クラテル;ヤルトクス;N-メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル;メチルカルバミド酸2,2-ジメチル-2,3-ジヒドロベンゾフラン-7-イル;メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル;フロダン;チヌフル;N-メチルカルバミド酸2,2-ジメチル-2,3-ジヒドロベンゾフラン-7-イル;フラダン;メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル;カルボフラン標準品;カルボフラン標準液;N-メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル;2,2-ジメチル-2,3-ジヒドロ-7-ベンゾ[b]フラニル=メチルカーバメート;N-メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル (別名 カルボフラン);N‐メチルカルバミン酸2,3‐ジヒドロ‐2,2‐ジメチル‐7‐ベンゾ[B]フラニル (別名 カルボフラン);CS_N-11405-250MG_カルボフラン
英語化学名:
Carbofuran
英語别名:
Nex;yalox;d1221;mef248;BURAON;Yaltox;brifur;D 1221;oms864;bay 70
CBNumber:
CB4322944
化学式:
C12H15NO3
分子量:
221.25
MOL File:
1563-66-2.mol

メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 物理性質

融点 :
150-153 °C(lit.)
沸点 :
200°C
比重(密度) :
1.18
蒸気圧:
2 x 10-5 mmHg at 33 °C (quoted, Verschueren, 1983)
屈折率 :
1.5200 (estimate)
貯蔵温度 :
0-6°C
溶解性:
Methylene chloride (>200 g/L), 2-propanol (20–50 g/L) (Worthing and Hance, 1991)
外見 :
Powder
色:
White, brown
水溶解度 :
Slightly soluble. 0.07 g/100 mL
Merck :
13,1813
BRN :
1428746
Henry's Law Constant:
3.88 (x 10-8 atm?m3/mol)at 30 °C (approximate - calculated from water solubility and vapor pressure)
暴露限界値:
OSHA PEL: TWA 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3.
CAS データベース:
1563-66-2(CAS DataBase Reference)
NISTの化学物質情報:
Carbofurane(1563-66-2)
EPAの化学物質情報:
7-Benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate(1563-66-2)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+,N,T
Rフレーズ  26/28-50/53
Sフレーズ  36/37-45-60-61-1/2
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS 番号 FB9450000
国連危険物分類  6.1(a)
容器等級  I
HSコード  29329990
有毒物質データの 1563-66-2(Hazardous Substances Data)
毒性 LD50 orally in mice: 2 mg/kg (Fahmy, 1970)
消防法 危-4-AL-S-II
化審法 一般化学物質
安衛法 有機溶剤中毒予防規則:第2種有機溶剤,57,57-2
PRTR法 第1種指定化学物質
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P273 環境への放出を避けること。
P284 呼吸用保護具を着用すること。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P310 ただちに医師に連絡すること。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。

メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 価格 もっと(18)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSM-531-08 カルボフラン
Carbofuran, 0.1 mg/mL in Acetonitrile
1563-66-2 1mL ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSAS-E0715 カルボフラン Standard
Carbofuran Standard, 5.0 mg/mL in MeOH
1563-66-2 1mL ¥11800 2018-12-26 購入
関東化学株式会社(KANTO) 49802-40 カルボフラン標準品
Carbofuran standard
1563-66-2 250mg ¥12000 2018-12-13 購入
関東化学株式会社(KANTO) 07741-96 カルボフラン標準品 >98.0%(HLC)
Carbofuran standard >98.0%(HLC)
1563-66-2 100mg ¥11000 2018-12-13 購入
Sigma-Aldrich Japan 32056 カルボフラン PESTANAL?, analytical standard
Carbofuran PESTANAL?, analytical standard
1563-66-2 250mg ¥16000 2018-12-25 購入

メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 化学特性,用途語,生産方法

外観

白色の結晶性粉末

溶解性

アセトンに溶け、水に極めて溶けにくい。

用途

農薬(殺虫剤)

農薬用途

殺虫剤

化学的特性

White Solid

化学的特性

Carbofuran is a broad-spectrum carbamate insecticide and nematicide. It is an odorless, white crystalline solid. On heating, it breaks down and can release toxic fumes, and irritating or poisonous gases. It is sparingly soluble in water, but very soluble in acetone, acetonitrile, benzene, and cyclohexone. The liquid formulations of carbofuran are classifi ed as RUPs because of their acute oral and inhalation toxicity to humans. Granular formulations are also classifi ed as an RUP. In fact, carbofuran was fi rst registered in the United States in 1969 and classifi ed as an RUP. Exposure to heat breaks down carbofuran, with the release of toxic fumes. Carbofuran is used for the control of soil-dwelling and foliar-feeding insects. It is also used for the control of aphids, thrips, and nematodes that attack vegetables, ornamental plants, crops of sunfl ower, potatoes, peanuts, soybeans, sugar cane, cotton, rice, and a variety of other crops

化学的特性

Carbofuran is white, odorless crystalline solid.

使用

Broad-spectrum, systemic insecticide, nematocide and acaricide applied in soil to control soil insects and nematodes or on foliage to control insects and mites.

使用

Carbofuran is used to control soil-dwelling insect pests and nematodes in a wide range of crops.

使用

Systemic insecticide, acaricide, nematocide.

使用

Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide.

一般的な説明

Carbofuran is an odorless white crystalline solid. Contact with skin may burn skin and eyes. When exposed to heat or flames Carbofuran may emit toxic oxides of nitrogen. Carbofuran is toxic by inhalation, skin contact, and/ or ingestion. Carbofuran is used as a pesticide.

空気と水の反応

Slightly soluble in water.

反応プロフィール

Carbofuran is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates. Carbofuran is unstable in an alkaline media. .

健康ハザード

Carbofuran is extremely poisonous. May be fatal if swallowed, inhaled, or absorbed through skin. Contact may burn skin or eyes. Probable lethal oral dose to humans 5 to 50 mg/kg or 7 drops to 1 teaspoon for 150 lb. person.

健康ハザード

The acute oral LD50 of carbofuran to male and female rats is about 8 mg/kg, while the acute dermal LD50 for rats is more than 3000 mg/kg. Carbofuran is mildly irritating to the eyes and skin of rabbits. The acute inhalation toxicity (LC50, 4 h) is 0.075 mg/L for rats. As with other carbamate compounds, carbofuran’s cholinesterase-inhibiting effect is short term and reversible. The symptoms of carbofuran poisoning include, but are not limited to, nausea, vomiting, abdominal cramps, sweating, diarrhea, excessive salivation, weakness, imbalance, blurring of vision, breathing diffi culty, increased blood pressure, and incontinence. Death may result at high doses from respiratory system failure associated with carbofuran exposure. Complete recovery from an acute poisoning by carbofuran, with no long-term health effects, is possible if exposure ceases and the victim has time to regain his or her normal level of cholinesterase and to recover from symptoms. Reports have indicated that risks from exposure to carbofuran are especially high among occupational workers and general public suffering with asthma, diabetes, cardiovascular disease, gastrointestinal or urogenital tracts disturbances. The available studies indicate carbofuran is unlikely to cause reproductive effects in humans at expected exposure levels. Studies indicate carbofuran is not teratogenic. No signifi cant teratogenic effects have been found in the offspring of rats given carbofuran (3 mg/kg/day) on days 5 to 19 of gestation

健康ハザード

Extremely toxic carbamate pesticide; routesof entry — ingestion, skin absorption, andinhalation of vapors; although the vaporpressure is very low [0.00002 torr at 33°C(91.4°F)], because of high toxicity, eventrace inhalation could be harmful; can causedeath if swallowed, absorbed through skinor inhaled; ingestion of about 0.5- to 2-gsubstance could cause death to humans; manifests acute, delayed, and chronic toxicity;choline sterase inhibitor; acute exposure maycause increased salivation, lacrimation, spontaneous urination, blurred vision, tremor,confusion, muscle twitching, and convulsion;high exposure may result in coma or respiratory collapse; other effects may includegastrointestinal effects, such as nausea, vomiting, abdominal pain, and diarrhea; cancause burn on skin contact; produced adversereproductive effects in experimental animals.
LD50 inhalation (guinea pig): 0.043 mg/L/4 hr(RTECS 1985 )
LD50 oral (rat): ~10 mg/kg
LD50 rat (skin): 120 mg/kg
Carbofuran hydrolyzes to less toxic 3-hydroxy carbamate and phenolic products.

火災危険

May release nitrogen oxides. Containers may explode in heat of fire. Avoid alkalies. Stable under neutral or acid conditions.

农业用途

Insecticide, Acaricide, Nematicide: Carbofuran is a broad-spectrum carbamate pesticide that kills insects, mites, and nematodes on contact or after ingestion. It is used against soil and foliar pests of field, fruit, vegetable, and forest crops. Carbofuran, granule form, is banned in the U.S. A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EU countries. There are 40 global suppliers.. According to the Ecological Incident Investigation System, carbofuran has been responsible for more avian deaths than any other pesticide.

製品名

A13-27164®; AU'ULTRAMICIN®; BAY 704143®; BAY 78537®; BRIFUR®; CARBODAN®; CARBOSIP 5G®; CRISFURAN®; CURETERR®; CHINUFUR®; D 1221®; DIAFURAN®; FMC 10242®; FURACARB®; FURADAN®; FURAN®; FURODAN®; KENFURAN®; KENOFURAN®; NEX®; NIA10242; NIAGARA 10242; NIAGARA NIA-10242; PILLARFURAN®; RAMPART®; YALTOX®

接触アレルゲン

It is a pesticide with insecticide properties, of the carbamate group. It was implicated as a sensitizer in two farmers

安全性プロファイル

to decomposition it emits toxic fumes of

職業ばく露

A potential danger to those involved in the manufacture, formulation, and application of this insecticide, acaricide, and nematocide.

環境運命予測

Biological. Carbofuran or their metabolites (3-hydroxycarbofuran and 3-ketocarbofuran) at normal and ten times the field application rate had no effect on Rhizobium sp. However, in a nitrogen-free culture medium, Azotobacter chroococcum growth was inhibited by carbofuran, 3-hydroxycarbofuran and 3-ketocarbofuran (Kale et al., 1989). Under in vitro conditions, 15 of 20 soil fungi degraded carbofuran to one or more of the following compounds: 3-hydroxycarbofuran, 3-ketocarbofuran, carbofuran phenol and 3-hydroxyphenol (Arunachalam and Lakshmanan, 1988).
Plant. Carbofuran is rapidly metabolized in plants to nontoxic products (Cremlyn, 1991). Metcalf et al. (1968) reported that carbofuran undergoes hydroxylation and hydrolysis in plants, insects and mice. Hydroxylation of the benzylic carbon gives 3-hydroxycarbofuran which is subsequently oxidized to 3-ketocarbofuran. In carrots, carbofuran initially degraded to 3-hydroxycarbofuran. This compound reacted with naturally occurring angelic acid in carrots forming a conjugated metabolite identified as 2,3-dihydro-2,2-dimethyl-7-(((methylamino)-carbonyl)oxy)-3-benzofuranyl (Z)-2-methyl-2-butenoic acid (Sonobe et al., 1981). Metabolites identified in three types of strawberries (Day-Neutral, Tioga and Tufts) were 2,3-dihydro-2,2-dimethyl-3-hydroxy-7-benzofuranyl-N-methylcarbamate, 2,3-dihydro-2,2-dimethyl-3-oxo-7-benzofuranyl-N-methylcarbamate, 2,3-dihydro-2,2-dimethyl-3-benzofuranol, 2,3-dihydro-2,2-dimethyl-3,7-benzofuranol and 2,3- dihydro-2,2-dimethyl-3-oxo-7-benzofuranol (Archer et al., 1977). Oat plants were grown in two soils treated with [14C]carbofuran. Most of the residues recovered in oat leaves were in the form of carbofuran and 3-hydroxycarbofuran. Other metabolites identified were 3-ketocarbofuran, a 3-keto-7-phenol and a 3-hydroxy-7-phenol (Fuhremann and Lichtenstein, 1980).
Surface Water. Sharom et al. (1980) reported that the half-lives for carbofuran in sterilized and non-sterilized water collected from the Holly Marsh in Ontario, Canada were 2.5 to 3 weeks at pH values of 7.8–8.0 and 8.0, respectively. The half-lives observed in distilled water were 2 and 3.8 weeks at pH values of 7.0–7.2 and 6.8, respectively. They reported that chemical degradation of dissolved carbofuran was more significant than microbial degradation.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987; Lewis, 1990).
The hydrolysis half-lives for carbofuran in a sterile 1% ethanol/water solution at 25°C and pH values of 4.5, 5.0, 6.0, 7.0 and 8.0 were 170, 690, 690, 8.2 and 1.0 week, respectively (Chapman and Cole, 1982).

代謝経路

The fate of carbofuran has been investigated in soils, plants, mammals, birds, fish and insects. Metabolic pathways include hydrolysis, oxidation (ring and N-methyl hydroxylation) and conjugation. The metabolism of carbofuran has been extensively reviewed by Schlagbauer and Schlagbauer (1972) and Kuhr and Dorough (1976). Metabolism in economic animals was reviewed by Akhtar (1985). Consequently the many primary publications are not usually cited.

貯蔵

Carbofuran should be stored in a cool, dry, well-ventilated place, in their original containers only. It should not be kept stored or used near heat, open flame, or hot surfaces

輸送方法

UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN 2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name RequiredUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Degradation

Carbofuran (1) is very stable in weakly acidic media and has a DT50 of <1 year at pH 4 (22°C). It is stable in neutral media but unstable in basic conditions (PM). Carbofuran was hydrolysed to the phenol (5) with a half-life of 67 minutes at 37.5 °C at pH 9.5. 3-Ketocarbofuran (3) and N-hydroxymethylcarbofuran (4) (Scheme 2) were hydrolysed faster than carbofuran in alkaline solution (Metcalf et al., 1968). Unlabelled carbofuran was dissolved in water and irradiated by sunlight in India for 30 days. Samples were extracted and analysed by GC and TLC.
Products were 3-ketocarbofuran (3) and the 4-hydroxycarbofuran phenol (8). (Raha and Das, 1990). Solid carbofuran was applied to glass plates and irradiated with fluorescent light or sunlight. 3-Hydroxycarbofuran (2) was detected after 2 days; 3-ketocarbofuran (3) was not detected (Metcalf et al., 1968). These pathways are illustrated in Scheme 1.

不和合性

Alkaline substances, acid, strong oxidizers, such as perchlorates, peroxides, chlorates, nitrates, permanganates.

廃棄物の処理

Alkaline hydrolysis is the recommended mode of disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

予防処置

During use/handling of carbofuran, workers should wear coveralls or a long-sleeved uniform, head covering, and chemical protective gloves made of materials such as rubber, neoprene, or nitrile. Occupational workers should know that areas treated with carbofuran are hazardous. The runoff of carbofuran material and the fi re control releases irritating or poisonous gases. It is advisable that workers should enter storehouses or carbofuran-treated close spaces with caution

メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 上流と下流の製品情報

原材料

準備製品


メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル 生産企業

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名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度

1563-66-2(メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル)キーワード:


  • 1563-66-2
  • furadang
  • Furodan
  • Karbofuranu
  • Me f248
  • mef248
  • Methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester
  • methylcarbamicacid2,3-dihydro-2,2-dimethyl-7-benzofuranylester
  • NA 2757
  • Nex
  • NIA 10242
  • nia10242
  • nia1024275wp
  • Niagara 10242
  • Niagara nia-10242
  • niagara10242
  • AGROFURAN
  • 4-DIMETHYL-AMINO-3,5-XYLYL-METHYLCARBAMATE
  • 2,3-DIHYDRO-2,2-DIMETHYL-BENZOFURAN-7-YL METHYLCARBAMATE
  • 2,3-Dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate
  • 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANOL N-METHYLCARBAMATE
  • 2,2-dimethyl-2,3-dihydrobenzofuranyl 7-methylcarbamate
  • 2,2-Dimethyl-2,2-dihydrobenzofuranyl-7-N-methylcarbamate
  • methylcarbamic acid 2,2-dimethyl-2,3-dihydro-7-benzofuranyl ester
  • BURAON
  • CARBOSIP
  • CARBOFURAN
  • CARBODAN
  • Bay 70143
  • CHINUFUR
  • CEKUFURAN
  • フラダン3G
  • カルボフラン
  • フラダン75WP
  • クラテル
  • ヤルトクス
  • N-メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル
  • メチルカルバミド酸2,2-ジメチル-2,3-ジヒドロベンゾフラン-7-イル
  • メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル
  • フロダン
  • チヌフル
  • N-メチルカルバミド酸2,2-ジメチル-2,3-ジヒドロベンゾフラン-7-イル
  • フラダン
  • メチルカルバミド酸2,3-ジヒドロ-2,2-ジメチルベンゾフラン-7-イル
  • カルボフラン標準品
  • カルボフラン標準液
  • N-メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル
  • 2,2-ジメチル-2,3-ジヒドロ-7-ベンゾ[b]フラニル=メチルカーバメート
  • N-メチルカルバミン酸2,3-ジヒドロ-2,2-ジメチル-7-ベンゾ[b]フラニル (別名 カルボフラン)
  • N‐メチルカルバミン酸2,3‐ジヒドロ‐2,2‐ジメチル‐7‐ベンゾ[B]フラニル (別名 カルボフラン)
  • CS_N-11405-250MG_カルボフラン
  • カルボフラン標準物質
  • カルボフラン STANDARD
  • カルボフラン Standard, 100 µg/mL in MeOH
  • カルボフラン Standard, 1000 µg/mL in MeOH
  • カルボフラン Standard, 5.0 mg/mL in MeOH
  • カルボフラン, 0.1 mg/mL in Acetonitrile
  • カルボフラン, 100 µg/mL in MeOH
  • カーバメート系殺虫剤
  • コリンエステラーゼ阻害剤
  • 浸透殺虫剤
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