インスリン 化学特性,用途語,生産方法
解説
インスリン，ホルモンの一種。膵臓のランゲルハンス島のβ細胞から分泌され，糖質の代謝に重要な役割を果す。 1921年に F.G.バンティングと C.H.ベストが発見し，34年に D.スコットが亜鉛添加によって容易に結晶化することを発見するに及んで，純度の高いインスリン製剤が広く供給されるようになった。
森北出版「化学辞典（第2版）
製法
インスリン，ポリペプチドホルモンの一つ．膵臓のランゲルハンス島のβ細胞から分泌される．ウシ，ブタ，ヒツジなどの膵臓から抽出，精製すると結晶状に単離される．ウシのインスリンは分子量6×103 で，中性溶液中では会合する．結晶には亜鉛が微量含まれている．
説明
Insulin is a polypeptide hormone that consists of two peptide chains bonded by two disulfide
bonds. The two chains are designated A and B. The A chain consists of 21 amino acids with
a third internal disulfidebond, and the B chain contains the remaining 30 amino acids. All
vertebrates produce insulin and the structure is similar in these species. For example, the insulin
produced in humans and porcine species differs by only one amino acid, and humans and
bovine insulin differ by three amino acids. Insulin plays a crucial role in several physiological
processes. These include the regulation of sugar in the body, fatty acid synthesis, formation of
triglycerides, and amino acid synthesis.
Insulin also promotes the storage of glucose as glycogen
in the liver. In this manner, insulin maintains glucose at a stable level in the bloodstream.
Insulin is most closely associated with diabetes. Diabetes results in excess blood glucose
levels (hyperglycemia) and the inability of cells to absorb glucose, which in turn deprives them
of energy.
来歴
Insulin derives its name from the Latin word insula for island. Insulin is produced in the
pancreas by β-cells in the islets of Langerhans (α-cells in the pancreas produce glucagon). Paul
Langerhans (1847–1888) discovered the islets of Langerhans, which were subsequently shown
to secrete insulin. Insulin binds to insulin receptors on cells and produces biochemical changes
that allow the cells to take in glucose.
Diabetes has been prevalent in humans throughout history, but relief from the disease was
not available until the 20th century.The termdiabetes comes from the Greek words diabainein,
meaning to pass through or siphon.In the late 1800s,it was known that diabetes was related to the pancreas,but it was not known exactly how. In 1901, Eugene Opie
(1873–1971) determined that diabetes was related to the islets of Langerhans. During the
early 20th century, knowledge was advanced on ductless glands and endocrine secretions that
fed directly into the bloodstream.Diseases were treated with extracts obtained from glands.
使用
Insulin plays a crucial role in several physiologicalprocesses. These include the regulation of sugar in the body, fatty acid synthesis, formation oftriglycerides, and amino acid synthesis.=Insulin also promotes the storage of glucose as glycogenin the liver. In this manner, insulin maintains glucose at a stable level in the bloodstream.Insulin is most closely associated with diabetes.
Diabetes must be managed by monitoring blood sugarlevels throughout the day, and using this information to adjust the diet and activities to keepblood glucose in an acceptable range; Insulin is usually administered through injections, but it can be deliveredusing other methods. Insulin pumps are small electronic devices that deliver insulin accordingto a programmed schedule throughout the day. In recent years oral sprays have beendeveloped to augment but not replace injected insulin. Another area of interest is deliveryusing dermal patches. Insulin cannot be delivered using conventional pills because stomachacidity denatures insulin. Although lack of insulin results in hyperglycemia,it is importantwhen administering insulin to prevent hypoglycemia. In hypoglycemia blood sugar is too low.Hypoglycemia in diabetics can occur from too much insulin, lack of food, exercise, or lackof carbohydrates. Its symptoms include increased heart rate, nervousness, perspiration, andshakiness. When this condition is recognized, diabetics consume carbohydrates such as candy,fruit,or fruit juice to boost blood sugar levels. In extreme cases,a person can have a severereaction and experience seizures or fall into a coma. Severe reaction to insulin is referred toas insulin shock.
定義
ChEBI: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other c
ntaining 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in
he treatment of type I and type II diabetes.
インスリン 上流と下流の製品情報
原材料
準備製品