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イブプロフェン

イブプロフェン 化学構造式
15687-27-1
CAS番号.
15687-27-1
化学名:
イブプロフェン
别名:
2-(4-イソブチルフェニル)プロピオン酸;rac-(R*)-α-メチル-4-(2-メチルプロピル)ベンゼン酢酸;(R)-イブプロフェン;rac-(R*)-2-(4-イソブチルフェニル)プロピオン酸;モギフェン;(-)-イブプロフェン;(R)-2-(4-イソブチルフェニル)プロパン酸;p-(2-メチルプロピル)-α-メチルフェニル酢酸;(R)-2-(p-イソブチルフェニル)プロピオン酸;(-)-(R)-イブプロフェン;(R)-α-メチル-4-(2-メチルプロピル)ベンゼン酢酸;rac-(R*)-2-(p-イソブチルフェニル)プロピオン酸;ブルフェン;p-(2-メチルプロピル)フェニル-α-メチル酢酸;(R)-(-)-イブプロフェン;(R)-2-(4-イソブチルフェニル)プロピオン酸;R-(-)-イブプロフェン;R(-)-イブプロフェン;ユニプロン;ブルファニック
英語化学名:
Ibuprofen
英語别名:
IP-82;rufen;rufin;Adran;Advil;Andran;Bluton;Brufen;Dolgin;Dolgit
CBNumber:
CB4336930
化学式:
C13H18O2
分子量:
206.28
MOL File:
15687-27-1.mol

イブプロフェン 物理性質

融点 :
77-78 °C(lit.)
沸点 :
157 °C (4 mmHg)
比旋光度 :
[α]D20 -1~+1°(c=1,C2H5OH)
比重(密度) :
1.0364 (rough estimate)
屈折率 :
1.5500 (estimate)
闪点 :
9℃
貯蔵温度 :
-20?C Freezer
溶解性:
Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates.
酸解離定数(Pka):
pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate)
外見 :
Crystalline Powder
色:
white to off-white
水溶解度 :
insoluble
Merck :
14,4881
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey:
HEFNNWSXXWATRW-UHFFFAOYSA-N
CAS データベース:
15687-27-1(CAS DataBase Reference)
NISTの化学物質情報:
Ibuprofen(15687-27-1)
EPAの化学物質情報:
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-63-51/53-39/23/24/25-23/24/25-11
Sフレーズ  36-61-36/37-45-16-7
HSコード  29163920
有毒物質データの 15687-27-1(Hazardous Substances Data)
毒性 LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi)
化審法 (9)-183
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P311 医師に連絡すること。
P405 施錠して保管すること。

イブプロフェン 価格 もっと(39)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00009030 イブプロフェン
Ibuprofen
15687-27-1 100mg ¥16800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00009030 イブプロフェン
Ibuprofen
15687-27-1 200mg ¥20200 2018-12-26 購入
東京化成工業 I0415 2-(4-イソブチルフェニル)プロピオン酸 >98.0%(GC)(T)
2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)
15687-27-1 100g ¥22600 2018-12-04 購入
東京化成工業 I0415 2-(4-イソブチルフェニル)プロピオン酸 >98.0%(GC)(T)
2-(4-Isobutylphenyl)propionic Acid >98.0%(GC)(T)
15687-27-1 25g ¥7400 2018-12-04 購入
関東化学株式会社(KANTO) 25861-1A イブプロフェン 99%
Ibuprofen 99%
15687-27-1 10g ¥26300 2018-12-13 購入

イブプロフェン MSDS


2-(4-Isobutylphenyl)-propionic acid

イブプロフェン 化学特性,用途語,生産方法

外観

白色の結晶性粉末

溶解性

エタノール及びアセトンに溶けやすく、水にほとんど溶けない。

用途

薬理研究用。

用途

プロピオン酸系化合物です。 シクロオキシゲナーゼ(COX)を阻害し、プ ロスタグランジン生合成抑制作用を示します。

用途

解熱?消炎?鎮痛剤

効能

鎮痛薬, 抗炎症薬, 解熱薬, シクロオキシゲナーゼ阻害薬

商品名

ブルフェン (科研製薬)

説明

Ibuprofen is a white, crystalline anti-infl ammatory drug used in numerous medications. It is the active ingredient marketed under various trade names including Advil, Motrin, and Nurofen. Ibuprofen is a nonsteroidal anti-infl ammatory drug (NSAID) used as a pain reliever (analgesic), fever reducer (antipyretic), and inflammation reducer. Infl ammation is a general physiological response to tissue damage characterized by swelling, pain, and heat.
Ibuprofen works by inhibiting the enzyme cyclooxygenase (COX), which in turn interferes with the synthesis of prostaglandins. COX exists as several coenzyme forms that are similar in structure: COX-1, COX-2, COX-3; ibuprofen is a nonselective inhibitor of both COX-1 and COX-2. COX-1 is continually produced in mammalian cells throughout the body in response to physiological stimuli. It is responsible for the production of prostaglandins, which get their name because it was originally believed they were synthesized in the prostate gland. In fact, prostaglandins are synthesized throughout the body and act like hormones by stimulating action in target cells. Prostaglandins, which are fatty acid compounds consisting of a 20-carbon chain including a 5 carbon ring, are involved in numerous physiological processes including renal function, blood clotting, and stomach mucus production. COX-2 is synthesized only in specifi c parts of the body (kidneys, brain, trachea) as needed and is therefore called an induced enzyme. COX-2 produces prostaglandins in response to tissue damage and infl ammation. Infl ammatory prostaglandins produce swelling, pain, and fever.

化学的特性

Colourless, Crystalline Solid

来歴

Ibuprofen was developed while searching for an alternative pain reliever to aspirin in the 1950s. It and related compounds were synthesized in 1961 by Stewart Adams, John Nicholson, and Colin Burrows who were working for the Boots Pure Drug Company in Great Britain. Adams and Nicholson filed for a British patent on ibuprofen in 1962 and obtained the patent in 1964; subsequent patents were obtained in the United States. The patent of Adams and Nicholson was for the invention of phenylalkane derivatives of the form shown in Figure 49.1, where R1 could be various alkyl groups, R2 was hydrogen or methyl, and X was COOH or COOR, with R being alkyl or aminoalkyl groups. The first clinical trials for ibuprofen were started in 1966. Ibuprofen was introduced under the trade name Brufen in 1969 in Great Britain. It was introduced in the United States in 1974. Ibuprofen was initially off ered by prescription, but it became available in over-the-counter medications in the 1980s.

使用

A common goal in the development of pain and inflammation medicines has been the creation of compounds that have the ability to treat inflammation, fever, and pain without disrupting other physiological functions. General pain relievers, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. A medication's specificaction toward COX-1 versus COX-2 determines the potential for adverse side effects. Medications with greater specificity toward COX-1 will have greater potential for producing adverse side effects. By deactivating COX-1, nonselective pain relievers increase the chance of undesirable side effects, especially digestive problems such as stomach ulcers and gastrointestinal bleeding. COX-2 inhibitors, such as Vioxx and Celebrex, selectively deactivate COX-2 and do not aff ect COX-1 at prescribed dosages. COX-2 inhibitors are widely prescribed for arthritis and pain relief. In 2004, the Food and Drug Administration (FDA) announced that an increased risk of heart attack and stroke was associated with certain COX-2 inhibitors. This led to warning labels and voluntary removal of products from the market by drug producers; for example, Merck took Vioxx off the market in 2004. Although ibuprofen inhibits both COX-1 and COX-2, it has several times the specificity toward COX-2 compared to aspirin, producing fewer gastrointestinal side effects.

使用

A selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency

使用

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

使用

Antibiotic

定義

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.

適応症

Ibuprofen (Advil, Motrin) is used as an analgesic and antipyretic as well as a treatment for rheumatoid arthritis and degenerative joint disease. The most frequently observed side effects are nausea, heartburn, epigastric pain, rash, and dizziness. Incidence of GI side effects is lower than with indomethacin.Visual changes and cross-sensitivity to aspirin have been reported. Ibuprofen inhibits COX-1 and COX-2 about equally. It decreases platelet aggregation, but the duration is shorter and the effect quantitatively lower than with aspirin. Ibuprofen prolongs bleeding times toward high normal value and should be used with caution in patients who have coagulation deficits or are receiving anticoagulant therapy.

brand name

Abbifen;Abuprohm;Abu-tab;Aches-n-pain;Acril;Actifen;Actiprofen;Actren;Addaprin;Advil 200 mg;Advil cold & sinus;Agisan;Aktren;Aldospray;Algiasdin;Algifor;Algisan;Algofer;Altior;Amersol;Anadin ibuprofen;Analgesico;Analgil;Analgyl;Anco;Antalgil;Antiflam;Antiruggen;Apsifen;Artofen;Artren;Artril;Artrofen;Bayer select ibuprofen pain reliever;Benflogin;Betagesic;Betaprofen;Brofen 200 mg;Brofen 400 mg;Brufert;Brufort;Buborone;Bufedon;Bufigen;Burana;Cesra;Children's advil;Children's motrin;Codafen continus;Contraneural;Contrneural;Cuisialigil;Cunil;Cuprofen;Dansida;Dentigoa forte;Dignoflex;Dimetap sinus;Dimidon;Dismenodl n;Dolgirit;Dolocyl;Dolo-dolgit;Dologesic;Dolo-neos;Dolo-puren;Doltibil;Dolven;Donjust-b;Dorival;Dristan sinus;Duradyne;Dura-ibu;Duralbuprofen;Dysdolen;Ecoprofen;Ediluna;Esprenit;Excedrin ib;Exidol;Exneural;Femafen;Femapirin;Femidol;Fenalgic;Fenlong;Genpril;Guildprofen;Halprin;Ibenon;Ibol;Ibosure;Ibruthalal;Ibu-attritin;Ibucasen;Ibu-cream;Ibufac;Ibufen tablets;Ibufen-l;Ibufug;Ibugel;Ibugesic;Ibuhexal;Ibular;Ibulav;Ibuleve;Ibulgan;Ibumetin;Ibuphlogont;Ibupirac;Ibuprin;Ibuprofen 200;Ibuprohm;Ibu-slow;Ibusure;Ibu-tab;Ibutad;Ibutid;Ibutop;Ibuvivimed;Ibux;Imben;Inabrin;Incefal;Inflam;Inoven;Inza;Iproben;Irfen;Isdol;Isisfen;Junifen;Kalma;Kos;Lacondan;Librofem;Librofen;Lidifen;Lisi-budol;Mediprofen;Melfen;Menado ibuprofen usp;Midol 200 advanced pain formula;Midol ib;Migrafen;Minadol;Moment;Motrin ib;Narfen;Neobrofen;Neobrufen;Nerofen;Niapren;Novaprin;Novogent;Novoprofen;Nu-ibuprofen;Optifen;Opturem;Pacifene;Padudent;Paxofen;Pfeil;Phor pain;Posodolor;Prontalgin;Recudik;Relcofen;Rheufen;Rimafen;Saleto-600;Seclodin;Sedaspray;Serviprofen;Sine-aid ib;Solufen;Spedifen;Stadasan;Superior pain medicine;Supreme pain medicine;Supren;Suspren;Tabalon;Tempil;Tendar;Trauma-dolgit;Ultraprin;Valprin.

世界保健機関(WHO)

Ibuprofen, a non-steroidal anti-inflammatory agent, was introduced in 1969. It was approved for sale without prescription in packages containing no more than 400 mg, in the United Kingdom in 1983. This action was followed by the USA, Canada and several European countries. Since this time reports of suspected adverse effects have increased. Most of these relate to gastrointestinal disturbances, hypersensitivity reactions but aseptic meningitis, skin rashes and renal damage have been recorded.

一般的な説明

Ibuprofen, 2-(4-isobutylphenyl)propionic acid (Motrin,Advil, Nuprin), was introduced into clinical practice followingextensive clinical trials. It appears to have comparableefficacy to aspirin in the treatment of RA, but with a lowerincidence of side effects. It has also been approved for usein the treatment of primary dysmenorrhea, which is thoughtto be caused by an excessive concentration of PGs and endoperoxides. However, a recent study indicates that concurrentuse of ibuprofen and aspirin may actually interferewith the cardioprotective effects of aspirin, at least in patientswith established cardiovascular disease. This is becauseibuprofen can reversibly bind to the platelet COX-1isozymes, thereby blocking aspirin’s ability to inhibit TXA2synthesis in platelets.

イブプロフェン 上流と下流の製品情報

原材料

準備製品


イブプロフェン 生産企業

Global( 384)Suppliers
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15687-27-1(イブプロフェン)キーワード:


  • 15687-27-1
  • alpha-(4-isobutylphenyl)propionicacid
  • alpha-(p-isobutylphenyl)propionic acid
  • alpha-2-(p-Isobutylphenyl)propionic acid
  • alpha-methyl-4-(2-methylpropyl)-benzeneaceticaci
  • alpha-p-isobutylphenylpropionicacid
  • Andran
  • Anflagen
  • Artril 300
  • artril300
  • Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
  • Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (.+/-.)-
  • Bluton
  • Brufanic
  • Brufen
  • Buburone
  • Butylenin
  • Dolgin
  • Dolgit
  • Ebufac
  • Epobron
  • eprobron
  • Haltran
  • Hydratropic acid, p-isobutyl-
  • Ibufen
  • Ibuprocin
  • Ibu-slo
  • IP-82
  • Lamidon
  • Liptan
  • Medipren
  • 2-(4-イソブチルフェニル)プロピオン酸
  • rac-(R*)-α-メチル-4-(2-メチルプロピル)ベンゼン酢酸
  • (R)-イブプロフェン
  • rac-(R*)-2-(4-イソブチルフェニル)プロピオン酸
  • モギフェン
  • (-)-イブプロフェン
  • (R)-2-(4-イソブチルフェニル)プロパン酸
  • p-(2-メチルプロピル)-α-メチルフェニル酢酸
  • (R)-2-(p-イソブチルフェニル)プロピオン酸
  • (-)-(R)-イブプロフェン
  • (R)-α-メチル-4-(2-メチルプロピル)ベンゼン酢酸
  • rac-(R*)-2-(p-イソブチルフェニル)プロピオン酸
  • ブルフェン
  • p-(2-メチルプロピル)フェニル-α-メチル酢酸
  • (R)-(-)-イブプロフェン
  • (R)-2-(4-イソブチルフェニル)プロピオン酸
  • R-(-)-イブプロフェン
  • R(-)-イブプロフェン
  • ユニプロン
  • ブルファニック
  • α-メチル-4-イソブチルベンゼン酢酸
  • (±)-イブプロフェン
  • (R)-α-メチル-4-イソブチルベンゼン酢酸
  • 2-(4-イソブチルフェニル)プロパン酸
  • ブブロン
  • rac-(R*)-2-(4-イソブチルフェニル)プロパン酸
  • (2R)-2-(4-イソブチルフェニル)プロパン酸
  • α-メチル-4-イソブチルフェニル酢酸
  • [αR,(-)]-α-メチル-4-(2-メチルプロピル)ベンゼン酢酸
  • ランデールン
  • イブプロフェン
  • rac-(2R*)-2-(4-イソブチルフェニル)プロパン酸
  • [R,(-)]-2-(4-イソブチルフェニル)プロピオン酸
  • 4-イソブチル-α-メチルベンゼン酢酸
  • 2-(p-イソブチルフェニル)プロピオン酸
  • α-メチル-4-(2-メチルプロピル)ベンゼン酢酸
  • R,S-イブプロフェン
  • [2R,(-)]-2-[4-(2-メチルプロピル)フェニル]プロパン酸
  • 4-イソブチル-α-メチルフェニル酢酸
  • イブプロフェン標準品
  • RAC イブプロフェン
  • イブプロフェン, 結晶
  • イブプロフェン 溶液
  • イブプロフェン (JP17)
  • 生化学
  • 阻害剤
  • 代謝産物
  • 非ステロイド系消炎薬
  • 感覚器作用薬
  • 解熱鎮痛薬
  • 抗リウマチ薬
  • 消炎薬
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