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キシリトール

キシリトール 化学構造式
87-99-0
CAS番号.
87-99-0
化学名:
キシリトール
别名:
キシリトール;キリット;L-キシリトール;キシリトン;キシラニット;トランス;D-キシリトール;キシリットT;クリニット;キシリット;オイトリット;D-xylo-ペンチトール;キシリトル;キシリト-ル;キシリトール標準品;キシリトール, 99%;キシリトール (JP17)
英語化学名:
Xylitol
英語别名:
djmt;Kylit;XYLIT;XYLITE;Xilite;Meso-X;Xylito;eutrit;kannit;Klinit
CBNumber:
CB4353243
化学式:
C5H12O5
分子量:
152.15
MOL File:
87-99-0.mol

キシリトール 物理性質

融点 :
94-97 °C(lit.)
沸点 :
215~217℃
比重(密度) :
1.515
屈折率 :
1.3920 (estimate)
貯蔵温度 :
2-8°C
溶解性:
H2O: 0.1 g/mL, clear, colorless
外見 :
Crystalline Powder
色:
White
水溶解度 :
SOLUBLE
Sensitive :
Hygroscopic
Merck :
14,10085
BRN :
1720523
InChIKey:
HEBKCHPVOIAQTA-QWWZWVQMSA-N
CAS データベース:
87-99-0(CAS DataBase Reference)
NISTの化学物質情報:
Xylitol(87-99-0)
EPAの化学物質情報:
Xylitol(87-99-0)

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  24/25-36-26
WGK Germany  2
RTECS 番号 ZF0800000
3
TSCA  Yes
HSコード  29054910
毒性 LD50 orally in mice: approx 22 g/kg (Salminen)
化審法 (9)-315 届出不要化学物質

キシリトール 価格 もっと(38)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA16944 キシリトール, 99%
Xylitol, 99%
87-99-0 100g ¥6040 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01AFAA16944 キシリトール, 99%
Xylitol, 99%
87-99-0 500g ¥24120 2018-12-26 購入
東京化成工業 X0018 キシリトール >98.0%(T)
Xylitol >98.0%(T)
87-99-0 500g ¥8000 2018-12-04 購入
東京化成工業 X0018 キシリトール >98.0%(T)
Xylitol >98.0%(T)
87-99-0 25g ¥1600 2018-12-04 購入
関東化学株式会社(KANTO) 22598-2A キシリトール >99.0%
Xylitol >99.0%
87-99-0 25g ¥3300 2018-12-13 購入

キシリトール MSDS


Xylitol

キシリトール 化学特性,用途語,生産方法

外観

白色, 結晶〜結晶性粉末

定義

本品は、次の化学式で表される五価の糖アルコールである。

溶解性

水に易溶。メタノールに微溶。エーテルに不溶。水に極めて溶けやすく、エタノールに溶けにくい。

化粧品の成分用途

保湿.湿潤剤、保水剤、香味剤、消臭剤

効能

賦形剤, 甘味料, 栄養補給剤

商品名

キシリトール (コーアイセイ); キシリトール (ニプロ); キシリトール (光製薬); キシリトール (大塚製薬工場); キシリトール (扶桑薬品工業); キシリトール (扶桑薬品工業); キシリトール (東和薬品); キリット (大塚製薬工場); クリニット (共和クリティケア)

確認試験

(1) 本品の水溶液(1→2)1mLに硫酸鉄(Ⅱ)試液2mL及び水 酸化ナトリウム溶液(1→5)1mLを加えるとき,液は青緑色を 呈するが混濁を生じない.
(2) 本品を乾燥し,赤外吸収スペクトル測定法〈2.25〉の 臭化カリウム錠剤法により試験を行い,本品のスペクトルと 本品の参照スペクトルを比較するとき,両者のスペクトルは 同一波数のところに同様の強度の吸収を認める.

定量法

本品を乾燥し,その約0.2gを精密に量り,水に溶かし, 正確に100mLとする.この液10mLを正確に量り,ヨウ素瓶 に入れ,過ヨウ素酸カリウム試液50mLを正確に加え,水浴 中で15分間加熱する.冷後,ヨウ化カリウム2.5gを加え, 直ちに密栓してよく振り混ぜ,暗所に5分間放置した後,遊 離したヨウ素を0.1mol/Lチオ硫酸ナトリウム液で滴定 〈2.50〉する(指示薬:デンプン試液3mL).同様の方法で空 試験を行う.
0.1mol/Lチオ硫酸ナトリウム液1mL=1.902mg C5H12O5

純度試験

(1) 溶状 本品5gを10mLに溶かすとき,液は無色澄明で ある.
(2) 塩化物〈1.03〉 本品2.0gをとり,試験を行う.比較 液には0.01mol/L塩酸0.30mLを加える(0.005%以下).
(3) 硫酸塩〈1.14〉 本品4.0gをとり,試験を行う.比較 液には0.005mol/L硫酸0.50mLを加える(0.006%以下).
(4) 重金属〈1.07〉 本品4.0gをとり,第1法により操作し, 試験を行う.比較液には鉛標準液2.0mLを加える(5ppm以 下).
(5) ニッケル 本品0.5gを水5mLに溶かし,ジメチルグ リオキシム試液3滴及びアンモニア試液3滴を加えて5分間放 置するとき,液は赤色を呈しない.
(6) ヒ素〈1.11〉 本品1.5gをとり,第1法により検液を調 製し,試験を行う(1.3ppm以下).
(7) 糖類 本品5.0gを水15mLに溶かし,希塩酸4.0mLを 加え,還流冷却器を付け,水浴中で3時間加熱する.冷後, 水酸化ナトリウム試液で中和する(指示薬:メチルオレンジ 試液2滴).更に水を加えて50mLとし,その10mLをフラス コに量り,水10mL及びフェーリング試液40mLを加えて穏 やかに3分間煮沸した後,放置し,酸化銅(Ⅰ)を沈殿させる. 次に上澄液をガラスろ過器(G4)を用いてろ過し,沈殿を温湯 で洗液がアルカリ性を呈しなくなるまで洗い,洗液は先のガ ラスろ過器でろ過する.フラスコ内の沈殿を硫酸鉄(Ⅲ)試液 20mLに溶かし,これを先のガラスろ過器を用いてろ過した 後,水洗し,ろ液及び洗液を合わせ,80℃に加熱し, 0.02mol/L過マンガン酸カリウム液で滴定〈2.50〉するとき, その消費量は,1.0mL以下である.

貯法

容器 気密容器.

乾燥減量

1.0%以下(1g,減圧,酸化リン(Ⅴ),24時 間).

強熱残分

0.1%以下(1g).

化学的特性

White or almost white, crystalline powder or crystals.

化学的特性

The solubility of D-xylitol (D-xylopentan-1.2.3.4.5-pentaol) in water is approximately 1,690 g/L at room temperature. Xylitol is stable under the common processing conditions of foods.
Xylitol is, depending on the concentration, similarly or slightly sweeter than sucrose and noncariogenic.
In the European Union, xylitol is approved as E 967 for a large number of food applications. In the United States, it is approved for use in foods following Good Manufacturing Practice and it is also approved in many other countries.

化学的特性

Xylitol occurs as a white, granular solid comprising crystalline, equidimensional particles having a mean diameter of about 0.4–0.6 mm. It is odorless, with a sweet taste that imparts a cooling sensation. Xylitol is also commercially available in powdered form, and several granular, directly compressible forms.

使用

Xylitol is a polyhydric alcohol that is a natural sugar substitute com- mercially made from xylan-containing plants (birch) hydrolyzed to xylose. it is as sweet as sucrose, dissolves quickly, and has a negative heat of solution which results in a cooling effect. it has 24 kcal/g. it is used in chewing gum, throat lozenges, and chocolate.

使用

sweetener and excipient, prevents acute otitis media

使用

A polyol substrate for xylitol and sorbitol dehydrogenases.

使用

As oral and intravenous nutrient; in anticaries preparations.

使用

xylitol is a humectant and skin-conditioning agent. It acts as a humidifier, drawing moisture from the air for skin absorption. Some manufacturers also cite a soothing and anti-microbial action. Xylitol is a naturally occurring sugar in birch bark and a range of fibrous fruits and vegetables, including corn.

定義

ChEBI: A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.

調製方法

Xylitol occurs naturally in many fruits and berries, although extraction from such sources is not considered to be commercially viable. Industrially, xylitol is most commonly derived from various types of hemicellulose obtained from such sources as wood, corn cobs, cane pulp, seed hulls, and shells. These materials typically contain 20–35% xylan, which is readily converted to xylose (wood sugar) by hydrolysis. This xylose is subsequently converted to xylitol via hydrogenation (reduction). Following the hydrogenation step, there are a number of separation and purification steps that ultimately yield high-purity xylitol crystals. The nature of this process, and the stringent purification procedures employed, result in a finished product with a very low impurity content. Potential impurities that may appear in small quantities are mannitol, sorbitol, galactitol, or arabitol.
Less commonly employed methods of xylitol manufacture include the conversion of glucose (dextrose) to xylose followed by hydrogenation to xylitol, and the microbiological conversion of xylose to xylitol.

Biotechnological Production

Xylitol is mostly produced by chemical hydrogenation of xylose which is obtained by hydrolysis of xylans of plants such as birch and beech trees, corn cobs, bagasse, or straw, but also by fermentation of xylose, for example, using Candida species. Xylose, especially for hydrogenation, requires a high purity. It may be obtained from wood extracts or pulp sulfite liquor, a waste product of cellulose production, by fermentation with a yeast that does not metabolize pentoses. Some strains of S. cerevisiae, Saccharomyces fragilis, Saccharomyces carlsbergensis, Saccharomyces pastoanus, and Saccharomyces marxianus are suitable for this purpose.
Hydrolysates of xylan-rich material are often treated with charcoal and ionexchangers to remove by-products causing problems in hydrogenation or fermentation.
Many studies of xylitol production by fermentation have been published. Different organisms, substrates, and conditions were investigated. As the starting material, xylose or xylose in combination with glucose was used. Fermentation was carried out in batch reactors as well as continuously.
Among the variations studied was cell recycling in a submerged membrane bioreactor for C. tropicalis with a high productivity of 12 g/Lh, a conversion rate of 85 % and a concentration of 180 g/L. Many studies addressed the immobilization of cells such as S. cerevisiae, C. guilliermondii, or D. hansenii, especially with calcium alginate.

応用例(製薬)

Xylitol is used as a noncariogenic sweetening agent in a variety of pharmaceutical dosage forms, including tablets, syrups, and coatings. It is also widely used as an alternative to sucrose in foods and as a base for medicated confectionery. Xylitol is finding increasing application in chewing gum, mouthrinses, and toothpastes as an agent that decreases dental plaque and tooth decay (dental caries). Unlike sucrose, xylitol is not fermented into cariogenic acid end products and it has been shown to reduce dental caries by inhibiting the growth of cariogenic Streptococcus mutans bacteria. As xylitol has an equal sweetness intensity to sucrose, combined with a distinct cooling effect upon dissolution of the crystal, it is highly effective in enhancing the flavor of tablets and syrups and masking the unpleasant or bitter flavors associated with some pharmaceutical actives and excipients.
In topical cosmetic and toiletry applications, xylitol is used primarily for its humectant and emollient properties, although it has also been reported to enhance product stability through a combination of potentiation of preservatives and its own bacteriostatic and bactericidal properties.
Granulates of xylitol are used as diluents in tablet formulations, where they can provide chewable tablets with a desirable sweet taste and cooling sensation, without the ‘chalky’ texture experienced with some other tablet diluents. Xylitol solutions are employed in tablet-coating applications at concentrations in excess of 65% w/w.Xylitol coatings are stable and provide a sweet-tasting and durable hard coating.
In liquid preparations, xylitol is used as a sweetening agent and vehicle for sugar-free formulations. In syrups, it has a reduced tendency to ‘cap-lock’ by effectively preventing crystallization around the closures of bottles. Xylitol also has a lower water activity and a higher osmotic pressure than sucrose, therefore enhancing product stability and freshness. In addition, xylitol has also been demonstrated to exert certain specific bacteriostatic and bactericidal effects, particularly against common spoilage organisms.
Therapeutically, xylitol is additionally utilized as an energy source for intravenous infusion therapy following trauma.

安全性プロファイル

Very low toxicity by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes. A sugar.

安全性

Xylitol is used in oral pharmaceutical formulations, confectionery, and food products, and is generally regarded as an essentially nontoxic, nonallergenic, and nonirritant material.
Xylitol has an extremely low relative glycemic response and is metabolized independently of insulin. Following ingestion of xylitol, the blood glucose and serum insulin responses are significantly lower than following ingestion of glucose or sucrose. These factors make xylitol a suitable sweetener for use in diabetic or carbohydrate-controlled diets.
Up to 100 g of xylitol in divided oral doses may be tolerated daily, although, as with other polyols, large doses may have a laxative effect. The laxative threshold depends on a number of factors, including individual sensitivity, mode of ingestion, daily diet, and previous adaptation to xylitol. Single doses of 20–30 g and daily doses of 0.5–1.0 g/kg body-weight are usually well tolerated by most individuals. Approximately 25–50% of the ingested xylitol is absorbed, with the remaining 50–75% passing to the lower gut, where it undergoes indirect metabolism via fermentative degradation by the intestinal flora.
An acceptable daily intake for xylitol of ‘not specified’ has been set by the WHO since the levels used in foods do not represent a hazard to health.
LD50 (mouse, IP): 22.1 g/kg
LD50 (mouse, IV): 12 g/kg
LD50 (mouse, oral): 12.5 g/kg
LD50 (rat, oral): 17.3 g/kg
LD50 (rat, IV): 10.8 g/kg
LD50 (rabbit, oral): 16.5 g/kg
LD50 (rabbit, IV): 4 g/kg

貯蔵

Xylitol is stable to heat but is marginally hygroscopic. Caramelization can occur only if it is heated for several minutes near its boiling point. Crystalline material is stable for at least 3 years if stored at less than 65% relative humidity and 25℃. Milled and specialized granulated grades of xylitol have a tendency to cake and should therefore be used within 9 to 12 months. Aqueous xylitol solutions have been reported to be stable, even on prolonged heating and storage. Since xylitol is not utilized by most microorganisms, products made with xylitol are usually safe from fermentation and microbial spoilage.
Xylitol should be stored in a well-closed container in a cool, dry place.

不和合性

Xylitol is incompatible with oxidizing agents.

規制状況(Regulatory Status)

GRAS listed. Approved for use as a food additive in over 70 countries worldwide, including Europe, the USA and Japan. Included in the FDA Inactive Ingredients Database (oral solution, chewing gum). Included in nonparenteral medicines licensed in the UK and USA. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

キシリトール 上流と下流の製品情報

原材料

準備製品


キシリトール 生産企業

Global( 363)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1178 58
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
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+86 18953170293
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Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58

87-99-0(キシリトール)キーワード:


  • 87-99-0
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  • キシリトール
  • キリット
  • L-キシリトール
  • キシリトン
  • キシラニット
  • トランス
  • D-キシリトール
  • キシリットT
  • クリニット
  • キシリット
  • オイトリット
  • D-xylo-ペンチトール
  • キシリトル
  • キシリト-ル
  • キシリトール標準品
  • キシリトール, 99%
  • キシリトール (JP17)
  • キシロース
  • 生化学
  • 糖アルコール
  • 甘味料
  • 強壮薬
  • 栄養剤
  • 糖質代謝作用薬
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