メズロシリンナトリウム 化学特性,用途語,生産方法
効能
抗生物質, 細胞壁合成阻害薬
説明
Mezlocillin is a β-lactam antibiotic and derivative of ampicillin . It is active against
B. fragilis,
E. lentum,
P. morbillorum, and
F. nucleatum (MICs = 8, 4, 2, and 4 μg/ml, respectively). Mezlocillin (32 μg/ml) is also active against 10 strains of
S. faecalis.
In vivo, mezlocillin (240 mg/kg) increases survival and reduces bacteremia in a rabbit model of
S. faecalis endocarditis. It completely eliminates lung
P. morbillorum,
E. lentum, and
F. nucelatum, but not
B. fragilis, in a rabbit model of pulmonary
P. morbillorum,
E. lentum,
F. nucelatum, and
B. fragilis infection when administered at a dose of 300 mg/kg. Formulations containing mezlocillin have been used in the treatment of various bacterial infections.
化学的特性
Mezlocillin sodium is white to slightly yellow cryst. powder
使用
Mezlocillin Sodium (cas# 59798-30-0) is a derivative of penicillin and an antimicrobial.
臨床応用
Mezlocillin (Mezlin) is an acylureidopenicillin with an antibacterialspectrum similar to that of carbenicillin andticarcillin; however, there are some major differences. It ismuch more active against most Klebsiella spp., P. aeruginosa,anaerobic bacteria (e.g., Streptococcus faecalis andB. fragilis), and H. influenzae. It is recommended for thetreatment of serious infections caused by these organisms.
Mezlocillin is not generally effective against β-lactamase–producing bacteria, nor is it active orally. It isavailable as a white, crystalline, water-soluble sodium saltfor injection. Solutions should be prepared freshly and, ifnot used within 24 hours, refrigerated. Mezlocillin and otheracylureidopenicillins, unlike carbenicillin, exhibit nonlinearpharmacokinetics. Peak plasma levels, half-life, and areaunder the time curve increase with increased dosage.Mezlocillin has less effect on bleeding time than carbenicillin,and it is less likely to cause hypokalemia.
メズロシリンナトリウム 上流と下流の製品情報
原材料
準備製品