rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 物理性質
- 沸点 :
- 474.1±35.0 °C(Predicted)
- 比重(密度) :
- 1.205±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- DMSO: ~17 mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- 13.99±0.20(Predicted)
- 色:
- 白い
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 価格
もっと(4)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC2195 |
Eliprodil |
119431-25-3 |
10mg |
¥39000 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC2195 |
Eliprodil |
119431-25-3 |
50mg |
¥148000 |
2023-06-01 |
購入 |
Sigma-Aldrich Japan
|
E2031 |
≥98% (HPLC), powder
Eliprodil ≥98% (HPLC), powder |
119431-25-3 |
10mg |
¥23500 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
E2031 |
≥98% (HPLC), powder
Eliprodil ≥98% (HPLC), powder |
119431-25-3 |
50mg |
¥70400 |
2021-03-23 |
購入 |
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 化学特性,用途語,生産方法
説明
N-
Methyl-
D-
aspartate (NMDA) receptors are calcium permeable ligand-
gated channels of the central nervous system that are activated after binding of the co-
agonists glutamate and glycine. Eliprodil is a non-
competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-
containing receptors (IC
50 = 1 μM), displaying greater than 100-
fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ
1 and σ
2 sites (K
is = 0.013 and 0.63 μM, respectively). It is effective
in vivo, blocking ischemia-
induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.
使用
Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.
生物活性
Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 上流と下流の製品情報
原材料
準備製品
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール 生産企業
Global( 116)Suppliers
rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール スペクトルデータ(1HNMR)
119431-25-3(rac-(R*)-α-(4-クロロフェニル)-4-(4-フルオロベンジル)-1-ピペリジンエタノール)キーワード:
- 119431-25-3
- SL 820715
- ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
- ELIPRODIL
- α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
- SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
- (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol
- 1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol
- 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
- α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol
- 1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol
- (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol
- エリプロジル
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