アラニジピン

アラニジピン 化学構造式
86780-90-7
CAS番号.
86780-90-7
化学名:
アラニジピン
别名:
1,4-ジヒドロ-2,6-ジメチル-4-(2-ニトロフェニル)-3,5-ピリジンジカルボン酸3-メチル5-(2-オキソプロピル);アサニジピン;アラニジピン;アラニジピン (JAN);3-メチル 5-(2-オキソプロピル) 2,6-ジメチル-4-(2-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート
英語名:
ARANIDIPINE
英語别名:
Sapresta;MPC-1304;ARANIDIPINE;Asanidipine;Aranidipine MPC1304;ARANIDIPINE USP/EP/BP;ARANIDIPINE MPC1304;MPC-1304;MPC 1304;Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels;3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
CBNumber:
CB4386708
化学式:
C19H20N2O7
分子量:
388.37
MOL File:
86780-90-7.mol

アラニジピン 物理性質

融点 :
155°
沸点 :
530.0±50.0 °C(Predicted)
比重(密度) :
1.284±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSO : 125 mg/mL (321.86 mM)
酸解離定数(Pka):
2.56±0.70(Predicted)

安全性情報

毒性 LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

アラニジピン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

アラニジピン 化学特性,用途語,生産方法

効能

血圧降下薬, カルシウムチャネル遮断薬

商品名

サプレスタ (大鵬薬品工業); ベック (日医工)

説明

Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca+2 entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.

アラニジピン 上流と下流の製品情報

原材料

準備製品


アラニジピン 生産企業

Global( 63)Suppliers
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China 9901 58

86780-90-7(アラニジピン)キーワード:


  • 86780-90-7
  • ARANIDIPINE
  • 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
  • MPC-1304
  • Sapresta
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester
  • Asanidipine
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester
  • 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Aranidipine MPC1304
  • ARANIDIPINE MPC1304;MPC-1304;MPC 1304
  • ARANIDIPINE USP/EP/BP
  • Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels
  • 1,4-ジヒドロ-2,6-ジメチル-4-(2-ニトロフェニル)-3,5-ピリジンジカルボン酸3-メチル5-(2-オキソプロピル)
  • アサニジピン
  • アラニジピン
  • アラニジピン (JAN)
  • 3-メチル 5-(2-オキソプロピル) 2,6-ジメチル-4-(2-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート
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