ChemicalBook
Chinese english Germany Korea

メチルアミン (約40% 水溶液)

メチルアミン (約40% 水溶液) 化学構造式
74-89-5
CAS番号.
74-89-5
化学名:
メチルアミン (約40% 水溶液)
别名:
メチルアミン (40%メタノール溶液, 約9.8mol/L);メチルアミン (約40% 水溶液);メタンアミン;アミノメタン;モノメチルアミン;メチルアミン;25% アミノメタン溶液;25% モノメチルアミン溶液;25%メチルアミン溶液;40% アミノメタン溶液;40% モノメチルアミン溶液;40%メチルアミン溶液;メチルアミン,テトラヒドロフラン溶液;アミノメタン溶液(メチルアミン溶液);メチルアミン溶液;メチルアミン (約40%水溶液, 約12mol/L);メチルアミン (約7%テトラヒドロフラン溶液, 約2mol/L);メチルアミン (約9%イソプロピルアルコール溶液, 約2mol/L);メチルアミン (約9%エタノール溶液, 約2mol/L);アミノメタン (40%メタノール溶液, 約9.8mol/L)
英語化学名:
Methylamine
英語别名:
MMA-40;MMA-50;CH3NH2;AMINE C1;Metilamine;Methylamin;Metyloamina;MERCURIALIN;METHYLAMINE;ai3-15637-x
CBNumber:
CB4387750
化学式:
CH5N
分子量:
31.06
MOL File:
74-89-5.mol

メチルアミン (約40% 水溶液) 物理性質

融点 :
-93 °C(lit.)
沸点 :
-6.3 °C(lit.)
比重(密度) :
0.785 g/mL at 25 °C
蒸気密度:
1.08 (20 °C, vs air)
蒸気圧:
27 psi ( 20 °C)
屈折率 :
n20/D 1.371
闪点 :
61 °F
貯蔵温度 :
Flammables area
溶解性:
highly soluble in water (108g/100g) at 25°C; soluble in alcohol and miscible with ether; HCl salt is soluble in water and absolute alcohol; compound is insoluble in chloroform, acetone, ether, and ethyl acetate
酸解離定数(Pka):
10.63(at 25℃)
比重:
0.901 (20℃/4℃) (40% Soln.)
PH:
14 (H2O, 20°C)
爆発限界(explosive limit):
4.9-20.8%
水溶解度 :
Miscible with water, ethanol, benzene, acetone and ether.
Merck :
14,6014
BRN :
741851
Henry's Law Constant:
(x 10-5 atm?m3/mol): 1.11 at 25 °C (Christie and Crisp, 1967)
暴露限界値:
TLV-TWA 10 ppm (~12.3 mg/m3)(ACGIH, MSHA, and OSHA); IDLH 100 ppm (NIOSH).
安定性::
Stable. Highly flammable. Note wide explosion limits. Incompatible with oxidizing agents, acids, alkalies, alkaline earth metals, copper and its alloys, zinc and its alloys.
CAS データベース:
74-89-5(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F+,Xn,C,F,T
Rフレーズ  12-20-37/38-41-34-20/22-11-39/23/24/25-36/37/38-23/24/25-40-19
Sフレーズ  7-16-26-36/37-45-29-36/37/39-3/7-3-39-33
RIDADR  UN 3286 3/PG 2
WGK Germany  2
RTECS 番号 PF6300000
4.5-31
自然発火温度 806 °F
TSCA  Yes
国連危険物分類  3
容器等級  II
HSコード  29211100
毒性 LD50 orally in rats: 100-200 mg/kg (Kinney); LC50 in rats: 0.448 ml/l (Sarkar, Sastry)
消防法 危険物第4類第一石油類(水溶性)
化審法 優先評価化学物質
安衛法 有機溶剤中毒予防規則:第2種有機溶剤,57,57-2
PRTR法 第1種指定化学物質
毒劇物取締法 III
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H220 極めて可燃性/引火性の高いガス 可燃性/引火性ガス 1 危険 P210, P377, P381, P403
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H280 加圧ガス;熱すると爆発のおそれ 高圧ガス 高圧ガス
液化ガス
溶解ガス
警告 P410+P403
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H333 吸入すると有害のおそれ 急性毒性、吸入 5 P304+P312
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P304 吸入した場合:
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。
P370+P378 火災の場合:消火に...を使用すること。
P403+P235 換気の良い場所で保管すること。涼しいところに 置くこと。
P405 施錠して保管すること。

メチルアミン (約40% 水溶液) 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

メチルアミン (約40% 水溶液) 化学特性,用途語,生産方法

外観

無色~ほとんど無色, 澄明の液体

溶解性

水, アルコールに易溶。水及びエタノールと任意の割合で混和する。

用途

有機合成原料。

用途

農薬?医薬?有機ゴム(加硫促進剤)原料、医薬品(エフェドリン)、染料、スラリー爆薬などの原料

化学的特性

Methylamine is a colorless, fi sh-like smelling gas at room temperature. It is used in a variety of industries, such as the manufacture of dyestuffs, treatment of cellulose, acetate rayon, as a fuel additive, rocket propellant, and in leather tanning processes.

化学的特性

colourless gas (or solution in water or methanol)

化学的特性

Methylamine is a colorless gas with a fish- or ammonia-like odor; at low concentrations a fishy odor. Shipped as a liquefied compressed gas. The odor threshold is 3.2 ppm.

化学的特性

Methylamine is a derivative of ammonia in which a methyl group is substituted for a hydrogen (Schweizer et al 1978). Its reactivity is governed primarily by the unshared pair of electrons on the nitrogen, therefore methylamine is a strongly alkaline base whose most characteristic reaction is the formation of salts with acids. It will react with acid halides and acid anhydrides to form N-substituted amines. Methylamine reacts with nitrous acid to form methanol with liberation of nitrogen. It is capable of reacting with aldehydes to form aldimines or Schiffs bases (Astle 1961).

物理的性質

Colorless, flammable gas with a strong ammonia-like odor. An experimentally determined recognition odor threshold concentration of 21 ppbv was reported by Leonardos et al. (1969). Odor threshold concentrations of 4.7 ppmv and 35 ppbv were experimentally determined by Nishida et al. (1979) and Nagata and Takeuchi (1990), respectively.

使用

Methylamine is used in dyeing and tanning;in photographic developer, as a fuel additive,and as a rocket propellant. It is also usedin organic synthesis and as a polymerizationinhibitor. It occurs in certain plants, such asMentha aquatica.

使用

Intermediate for accelerators, dyes, pharmaceuticals, insecticides, fungicides, surface active agents, tanning, dyeing of acetate textiles, fuel additive, polymerization inhibitor, component of paint removers, solvent, photographic developer, rocket propellent.

定義

ChEBI: The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.

定義

A colorless flammable gas that smells like ammonia. It is the simplest primary amine, used for making herbicides and other organic chemicals.

定義

methylamine: A colourless flammablegas, CH3NH2; m.p. –93.5°C; b.p.–6.3°C. It can be made by a catalyticreaction between methanol and ammoniaand is used in the manufactureof other organic chemicals.

調製方法

Several methods are currently used for synthesis of methylamine. Virtually all produce a mixture of primary, secondary, and tertiary amines which can be continuously separated by distillation and extraction. The most commonly used synthesis involves heating ammonium chloride and methyl alcohol (ratio varies from 2:1 to 6:1, depending on desired ratio of amines) to about 300°C in the presence of a catalyst such as zinc chloride. Alternatively, methylamine can be synthesized by heating ammonium chloride and formaldehyde in the presence of H2 and a hydrogenation catalyst such as nickel or platinum. Methylamine is generally marketed as a liquid or a 33% aqueous solution (HSDB 1988).

一般的な説明

A colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at 20.3°F hence vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.

空気と水の反応

Highly flammable. Very soluble in water; the solutions are strongly basic and therefore corrosive. Liquid fumes in air.

反応プロフィール

METHYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

危険性

(Gas and liquid) Dangerous fire risk. Explosive limits in air 5–21%. Strong irritant to tissue. Eye, skin and upper respiratory tract irritant.

健康ハザード

Exposures to methylamine are known to cause adverse health effects among occupational workers. The workers demonstrate symptoms of toxicity that include, but are not limited to, irritation to the eyes, nose, and throat. Studies have indicated that the compound causes injury to the eyes through corneal opacities and edema hemorrhages in the conjunctiva, and injury to the liver. Studies of Guest and Varma indicated no signifi cant deleterious effects on the internal organs or skeletal deformities in experimental mice

健康ハザード

Exposures to methylamine are known to cause adverse health effects among occupational workers. The workers demonstrate symptoms of toxicity that include, but are not limited to, irritation to the eyes, nose, and throat. Studies have indicated that the compound causes injury to the eyes through corneal opacities and edema hemorrhages in the conjunctiva, and injury to the liver. Studies of Guest and Varma indicated no signifi cant deleterious effects on the internal organs or skeletal deformities in experimental mice.

健康ハザード

VAPOR: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. LIQUID: Will burn skin and eyes.

健康ハザード

250 ppm produced damage to respiratorymucosa of the nasal turbinates. Exposureto 750 ppm produced severe body weightlosses, liver damage, and nasal degenerativechanges.
Any adverse health effects in humans dueto methylamine, other than its irritant action,is unknown.
LC50 value, inhalation (mice): 2400 mg/kg/2 h.

健康ハザード

Most of the studies on the toxicity of methylamine suggest it acts locally as an irritant and a sensitizer. Vapors result in eye irritation with tearing and inflammation with repeated exposure capable of inducing corneal damage. Exposure by inhalation irritates the mucous membranes of the nose, throat and lung, leading to coughing and respiratory distress. Skin contact with methylamine can lead to burns and dermatitis (Beard and Noe 1981). First aid for skin exposure requires immediate flushing with water.
Persons exposed to methylamine can detect a faint fishlike odor at less than 10 p.p.m. Little irritation occurs however, above 20 p.p.m. Methylamine can induce temporary irritation of the eyes, nose, and throat. The permissible exposure level (PEL) has been set at 10 p.p.m. (OSHA 1977) and the level immediately dangerous to life or health (IDLH) is 100 p.p.m. (Standards Completion Program, OSHA and NIOSH 1978).

火災危険

FLAMMABLE. POISONOUS GASES MAY BE PRODUCED IN FIRE. Containers may explode in fire. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic nitrogen oxides may be formed. Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back.

工業用途

Methylamine and its hydrochloride salt are widely used in organic synthesis for introducing the methylamino group. In 1976, industrial consumption was 32,000 tons/year. One of its most important uses is in the preparation of amide-type surfactants. It is also used in the preparation of drugs such as adrenaline and synthetic caffeine. It serves as the base for more than twenty commercial products, among those included are photographic developers, insecticides, and antihistamine drugs (Beard and Noe 1981). It is also widely used in tanning and has been used in the separation of aromatics from aliphatic hydrocarbons (Sittig 1981).

安全性プロファイル

Poison by subcutaneous route. Moderately toxic by inhalation. A severe skin irritant. Mutation data reported. A strong base. Flammable gas at ordinary temperature and pressure. Very dangerous fire hazard when exposed to heat, flame, or sparks. Explosive when exposed to heat or flame. To fight fire, stop flow of gas. Forms an explosive mixture with nitromethane. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.

職業ばく露

Methylamine is used in organic synthesis; a starting material for N-oleyltaurine, a surfactant; and p-N-methylaminophenol sulfate, a photographic developer. It has possible uses in solvent extraction systems in separation of aromatics from aliphatic hydrocarbons. It is also used in the synthesis of many different pharmaceuticals; pesticides and rubber chemicals.

Source

Methylamine was detected in cauliflower (65 ppm), carrots (3,970 ppm), tea leaves (50 ppm), red and white cabbage (3.4 to 22.7 ppm), corn (27 ppm), kale leaves (16.6 ppm), barley seeds (4.5 ppm), epidermis of apples (4.5 ppm), celery (6.4 ppm), sweetflag, celandine, and tobacco leaves (Duke, 1992).

環境運命予測

Photolytic. The rate constant for the reaction of methylamine and OH radicals in the atmosphere at 300 K is 1.3 x 10-13 cm3/molecule?sec (Hendry and Kenley, 1979).
Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. In an aqueous solution, chloramine reacted with methylamine to form Nchloromethylamine (Isaac and Morris, 1983).
Reacts with acids forming water-soluble salts.

代謝

Methylamine is a normal body constituent in several species and is known to be generated endogenously from epinephrine (Schayer et al 1952) and creatine (Davis and DeRopp 1961). It has also recently been detected in the urine of male CBA/cA mice treated with N-methylformamide (Kestell et al 1985). Mammalian metabolism of methylamine is rapid yet the enzymes involved are not yet known. Simehnhoff (1975) suggested that methylamine is methylated to dimethylamine as it appeared not to be oxidized by amine oxidases yet was rapidly absorbed and not excreted in the urine. Dar et al (1985) conducted studies using methyl-[14C]- labeled methylamine injected i.p. into rats to assess the role of monoamine oxidase in the metabolism of methylamine in the rats. Methylamine underwent rapid oxidation as more than 30% of the 14C was recovered as 14CO2 in the first 2-6 h following exposure and 52% was expired in the first 24 h. Pretreatment of the rats with long acting monoamine oxidase inhibitors significantly inhibited methylamine metabolism, however short term inhibitors were without effect. Combinations of the drugs suggested that monoamine oxidase was not responsible for metabolism of methylamine and that a closely related enzyme such as methylamine oxidase, previously proposed by Werner and Seiber (1963), may be involved.
It has also been reported that intestinal microflora may degrade methylamine (Iyer and Kailio 1958). Dar et al (1985) found that pretreatment of rats with neomycin to reduce bacterial microorganisms resulted in only a slight inhibition of 14C expiration during the initial 6 h following methylamine administration. These results indicate that, at least in the rat, bacterial oxidation of methylamine in the intestine is negligible.

貯蔵

Methylamine is stored in a cool, well-ventilated noncombustible area separatedfrom possible sources of ignition andoxidizing substances and mercury. Itssolutions are stored in a flammable liquidstorage room or cabinet. The gas is shippedin steel cylinders or tank cars; the liquid isshipped in steel drums or tank cars.

輸送方法

UN1061 Methylamine, anhydrous, Hazard Class: 2.1; Labels: 2.1-Flammable gas. UN1235 Methylamine, aqueous solution, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner.

純化方法

Dry the amine with sodium or BaO. It is commercially available in metal cylinders. [Beilstein 4 IV 118.]

不和合性

A medium-strong base. Reacts violently with strong acids; mercury, strong oxidizers; nitromethane. Corrosive to copper, zinc alloys; aluminum, and galvanized surfaces.

廃棄物の処理

Return refillable compressed gas cylinders to supplier. Controlled incineration (incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions).

メチルアミン (約40% 水溶液) 上流と下流の製品情報

原材料

準備製品


メチルアミン (約40% 水溶液) 生産企業

Global( 0)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度

74-89-5(メチルアミン (約40% 水溶液))キーワード:


  • 74-89-5
  • METHYLAMINE, 40%, AQUEOUS SOLUTIONMETHYLAMINE, 40%, AQUEOUS SOLUTIONMETHYLAMINE, 40%, AQUEOUS SOLUTION
  • methylamine(solutions)
  • methylamine,anhydre
  • methylamine,anhydrous
  • methylamine,aqueoussolution
  • methylamine2,4-dichlorophenoxyacetate
  • Methylaminen
  • methylaminesolutions
  • Metilamine
  • Metyloamina
  • metyloamina(polish)
  • METHYLAMINE, PRESSURE TIN WITH 100 ML
  • METHYLAMINE SOLUTION, 33% WT. IN ABSOLUT
  • METHYLAMINE SOLUTION, 41% IN WATER
  • METHYLAMINE, 40 WT. % SOLUTION IN WATER
  • METHYLAMINE SOLUTION, 33% IN ABS. ETHYL ALCOHOL
  • METHYLAMINE, PRESSURE TIN WITH 250 ML NE T ~175 G
  • METHYLAMINE, CYL. WITH 2 L NET ~1.1 KG
  • Methylamine solution 2.0 M in tetrahydrofuran
  • Methylamine solution 40 %
  • METHYLAMINE, 2.0M SOLUTION IN METHYL ALC OHOL
  • METHYLAMINE, CYL. WITH 7 L NET ~4 KG
  • METHYLAMINE, VIAL WITH 25 ML
  • METHYLAMINE, CYL. WITH 14.3 L NET ~8 KG
  • METHYLAMINE, 2.0M SOLUTION IN TETRAHYDRO -FURAN
  • METHYLAMINE, ANHYDROUS, 98+%
  • METHYLAMINE ANHYDROUS CYL. WITH 27 L NET ~15 KG
  • MethylamineForSynthesis
  • Methylamine alcohol solution
  • Methylamine,40%w/waq.soln.
  • メチルアミン (40%メタノール溶液, 約9.8mol/L)
  • メチルアミン (約40% 水溶液)
  • メタンアミン
  • アミノメタン
  • モノメチルアミン
  • メチルアミン
  • 25% アミノメタン溶液
  • 25% モノメチルアミン溶液
  • 25%メチルアミン溶液
  • 40% アミノメタン溶液
  • 40% モノメチルアミン溶液
  • 40%メチルアミン溶液
  • メチルアミン,テトラヒドロフラン溶液
  • アミノメタン溶液(メチルアミン溶液)
  • メチルアミン溶液
  • メチルアミン (約40%水溶液, 約12mol/L)
  • メチルアミン (約7%テトラヒドロフラン溶液, 約2mol/L)
  • メチルアミン (約9%イソプロピルアルコール溶液, 約2mol/L)
  • メチルアミン (約9%エタノール溶液, 約2mol/L)
  • アミノメタン (40%メタノール溶液, 約9.8mol/L)
  • アミノメタン (約40%水溶液, 約12mol/L)
  • アミノメタン (約7%テトラヒドロフラン溶液, 約2mol/L)
  • アミノメタン (約9%イソプロピルアルコール溶液, 約2mol/L)
  • アミノメタン (約9%エタノール溶液, 約2mol/L)
  • メタンアミン (約40%水溶液, 約12mol/L)
  • メチルアミン(40%メタノール溶液,約9.8 MOL/L)
  • メチルアミン40%水溶液
  • モノメチルアミン40%水溶液
  • メチルアミン溶液(40%溶液)
  • メチルアミン STANDARD
  • メチルアミン 溶液
  • メチルアミン standard, 2500 µg/mL in Water
  • 構造分類
  • 官能性 & α,ω-二官能性アルカン
  • 生化学
  • 糖鎖合成用反応剤
  • 一官能性アルカン
  • アルキルアミン
Copyright 2017 © ChemicalBook. All rights reserved