フルニソリド

フルニソリド 価格 もっと(3)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TRCF500485	フルニゾリド Flunisolide	3385-03-3	10mg	￥299700	2024-03-01	購入
東京化成工業	F0437	フルニソリド >98.0%(HPLC) Flunisolide >98.0%(HPLC)	3385-03-3	1g	￥25200	2023-06-01	購入
Sigma-Aldrich Japan	F5021	フルニソリド ≥97% Flunisolide ≥97%	3385-03-3	100mg	￥28500	2024-03-01	購入

フルニソリド 化学特性,用途語,生産方法

化学的特性

White Solid

使用

Synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.

一般的な説明

The portion of a flunisolide (AeroBid,Nasarel) dose that is swallowed is rapidly converted to the6β-hydroxy metabolite after first-pass metabolism in theliver. The 6β-hydroxy metabolite is approximately as activeas hydrocortisone itself, but the small amount produced usuallyhas limited systemic effects. Water-soluble conjugatesare inactive.

臨床応用

Flunisolide is an acetone ketal (acetonide) with a 6α-fluoro group and a free C-21 hydroxyl group. The acetonide decreases mineralocorticoid activity, and the 6α-fluoro group increases glucocorticoid activity. It is not a prodrug, because it has the free hydroxyl group at C-21. Flunisolide has approximately 20% of the receptor affinity as budesonide, and approximately 40% of the inhaled dose is systemically bioavailable.

代謝

When administered intranasally or by inhalation, flunisolide is rapidly absorbed from nasal or lung tissue(94). This corticosteroid is efficiently metabolized by the liver to inactive metabolites with no apparent effects on adrenal function with long-term therapy. Flunisolide that is swallowed undergoes extensive first-pass metabolism in the liver, and that which is absorbed directly from the nasopharyngeal mucosa or lung bypasses this initial metabolism. It is not known if the drug undergoes metabolism in the GI tract. Flunisolide is rapidly hydroxylated by CYP3A4 at the 6β position, followed by elimination of the 6α-fluoro group to its more polar 6β-hydroxy metabolite, which attains plasma concentrations that usually are greater than those for flunisolide.

フルニソリド 上流と下流の製品情報

原材料

準備製品

フルニソリド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006608290; 18621169109	market03@meryer.com	China	40241	62

3385-03-3(フルニソリド)キーワード:

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• 3385-03-3
• FLUNISOLIDE
• 1,4-PREGNADIEN-6-ALPHA-FLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE ACETONIDE
• -,cyclic16,17-acetalwithacetone
• pregna-1,4-diene-3,20-dione,6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy
• 6α-Fluoro-11b,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
• Aerobid M
• Bronalide
• Lunis
• Nisolid
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
• 6-FLUORO-11,21-DIHYDROXY-16,17-(ISOPROPYLIDENEDIOXY)PREGNA-1,4-DIENE-3,20-DIONE
• (6a,11b,16a)-6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone (7CI, 8CI)
• RS 3999
• Soluzione
• Synaclyn
• Flunisolide-d6
• (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 6-Fluoro-11,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
• 6α-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
• 6α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenebisoxy)-1,4-pregnadiene-3,20-dione
• 6α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
• (2S,6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-2-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
• Nasalide
• Nasarel
• Flunisolide Hemihydrate
• 6-FLUORO-11,16ALPHA,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 16,17-ACETONIDE
• Glucocorticoid Receptor,Apoptosis,ECM homeostasis,asthma,Inhibitor,Male Swiss Webster mice,fibroblast activation,Inflammation,inhibit,Flunisolide,eosinophil apoptosis
• (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
• フルニソリド
• シンタリス
• シナクリン
• ルニス
• エロビド
• 6α-フルオロ-11β,21-ジヒドロキシ-16α,17-(イソプロピリデンビスオキシ)プレグナ-1,4-ジエン-3,20-ジオン
• 6α-フルオロ-11β,21-ジヒドロキシ-16α,17α-(イソプロピリデンビスオキシ)-1,4-プレグナジエン-3,20-ジオン
• 6α-フルオロ-11β,21-ジヒドロキシ-16α,17α-(イソプロピリデンビスオキシ)プレグナ-1,4-ジエン-3,20-ジオン
• ブロナリド
• ナサリド
• 6-フルオロ-11,21-ジヒドロキシ-16,17-(イソプロピリデンジオキシ)プレグナ-1,4-ジエン-3,20-ジオン
• フルニゾリド
• (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-フルオロ-11-ヒドロキシ-8-(2-ヒドロキシアセチル)-6,6,9,13-テトラメチル-5,7-ジオキサペンタシクロ[10.8.0.02,9.04,8.013,18]イコサ-14,17-ジエン-16-オン
• 含フッ素生理活性化合物
• 生化学
• 有機合成化学
• ステロイド
• ステロイド (その他)
• フッ素化剤，含フッ素ビルディングブロック＆含フッ素生理活性化合物
• グルココルチコイド
• 耳鼻薬
• 抗アレルギー薬
• 消炎薬