GS-441524

 化学構造式
1355149-45-9
CAS番号.
1355149-45-9
化学名:
别名:
英語名:
GS-441524
英語别名:
GS-443902;2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;R-32-GS-441524;Remdesivir Impurity 11;Triphosphate / Redesivir-TP;R-32-GS-441524 Triphosphate;Remdesivir Nucleoside Triphosphate;GS 441524 triphosphate triethylammonium salt;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate);(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid
CBNumber:
CB44189084
化学式:
C12H16N5O13P3
分子量:
531.2
MOL File:
1355149-45-9.mol

GS-441524 物理性質

比重(密度) :
2.39±0.1 g/cm3(Predicted)
酸解離定数(Pka):
0.97±0.50(Predicted)

安全性情報

GS-441524 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

GS-441524 化学特性,用途語,生産方法

使用

GS 441524 Triphosphate is known to strongly inhibit feline peritonitis which is a highly lethal coronavirus disease in cats. Also useful in the potential treatment of ebola and emerging viruses.

主な応用

GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it), but GS-441524 has been found to be effective treatment for FIP and is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterinary use.

Advantages

GS-441524 is either similar to or more potent than remdesivir against SARS-CoV-2 in cell culture, with some researchers arguing that GS-441524 would be better than remdesivir for the treatment of COVID-19. Specific advantages cited include ease of synthesis, lower kidney and hepatotoxicity, as well as potential for oral delivery (which is precluded of remdesivir because of poor hepatic stability and first pass metabolism). The public health advocacy group, Public Citizen, in an open letter urged the DHHS and Gilead to investigate GS-441524 for the treatment of COVID-19, suggesting that GILEAD was not doing so for financial motives related to the longer intellectual property lifespan of Remdesivir. Direct efficacy against SARS-CoV-2 was demonstrated in a mouse model of COVID-19. A deuterium modified version of GS-441524 has been produced and has shown pre-clinical efficacy in both cell culture and mouse models by a team including members of Wuhan Institute of Virology.

GS-441524 上流と下流の製品情報

原材料

準備製品


GS-441524 生産企業

Global( 45)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED
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ivan@atkchemical.com China 32480 60
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 7836 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
Qiuxian Baitai New Material Co., LTD
+8618330912755
sale2@hbyalin.com China 1677 58
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316
admin@zhanyaobio.com China 2136 58
Shenzhen Shengda Pharma Limited
755-85269922 +8613424394241
sales@shengdapharm.com CHINA 310 58
Wisdom Drugs Co .,Ltd
+86-0519-85556805
Sales3@wisdomdrugs.com China 398 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58

  • 1355149-45-9
  • Remdesivir Nucleoside Triphosphate
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate)
  • ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogentriphosphate
  • Remdesivir Impurity 11
  • R-32-GS-441524 Triphosphate
  • R-32-GS-441524
  • Triphosphate / Redesivir-TP
  • (((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid
  • 2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • GS-443902
  • GS 441524 triphosphate triethylammonium salt
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