2,4-ジクロロフェノール 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
外観
白色～ほとんど白色粉末～結晶
溶解性
水に難溶 (2400mg/L), エタノール, アセトン, エーテルに易溶。
用途
農薬、医薬、殺菌剤、染料の製造
用途
環境試料中の内分泌攪乱物質のGC-MS分析に於いて標準品として使用されます。
用途
有機合成原料。
化学的特性
white to beige crystalline solid
物理的性質
Colorless to yellow crystals with a sweet, musty, or medicinal odor. At 40 °C, the average odor
threshold concentration and the lowest concentration at which an odor was detected were 29 and
5.4 μg/L, respectively. Similarly, at 25 °C, the average taste threshold concentration and the
lowest concentration at which a taste was detected were 2.5 and 0.98 μg/L, respectively (Young et
al., 1996).
使用
2,4-Dichlorophenol is a chlorinated derivative of phenol and is used as an intermediate for the preparation of herbicide 2,4-dichlorophenoxyacetic acid (D435680).
定義
ChEBI: A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.
一般的な説明
Colorless crystalline solid with a medicinal odor. Melting point 45°C. Sinks in water. Strong irritant to tissues; toxic by ingestion.
空気と水の反応
Insoluble in water.
反応プロフィール
2,4-Dichlorophenol can react vigorously with oxidizing agents. Can also react with acids or acid fumes. Incompatible with acid chlorides and acid anhydrides.
健康ハザード
Tremors, convulsions, shortness of breath, inhibition of respiratory system.
安全性プロファイル
Suspected carcinogen
with experimental carcinogenic and
teratogenic data. Poison by intraperitoneal
route. Moderately toxic by ingestion and
subcutaneous routes. An experimental
teratogen. Mutation data reported.
Combustible when exposed to heat or
flame. Can react vigorously with oxidizing
materials. To fight fre, use alcohol foam,
foam, CO2, dry chemical. When heated to
decomposition, or on contact with acid or
acid fumes, it emits hghly toxic fumes of
Cl-. See also CHLOROPHENOLS.
職業ばく露
2,4-Dichlorophenol is a commercially
produced substituted phenol used in the manufacture
of industrial and agricultural products; in synthesis of
pharmaceuticals. As an intermediate in the chemical industry, 2,4-DCP is utilized as the feedstock for the manufacture of 2,4-dichlorophenoxyacetic acid (2,4-D), and 2,4-D
derivatives (germicides, soil sterilants, etc.); certain methyl
compounds used in mothproofing, antiseptics and seed
disinfectants. 2,4-DCP is also reacted with benzene sulfonyl
chloride to produce miticides or further chlorinated to
pentachlorophenol, a wood preservative. It is thus a widely
used pesticide intermediate. The only group expected to be
at risk for high exposure to 2,4-DCP is industrial workers
involved in the manufacturing or handling of 2,4-DCP
and 2,4-D
発がん性
In mammalian cells in vitro 2,4-DCP produced
chromosomal aberrations and induced
unscheduled DNA synthesis; it was negative
for sister chromatid exchange in vivo and was
mostly negative in bacterial assays.
Oral exposure of pregnant rats to
750mg/kg/day for 10 gestational days induced
slightly decreased fetal weight, delayed ossification
of sternal and vertebral arches, and some
early embryonic deaths.10 Maternal deaths also
occurred at this dose, indicating that 2,4-DCP
was not selectively toxic to embryos or fetuses.
No effects were noted in dams or offspring
exposed at 375mg/kg/day.
A threshold limit value (TLV) has not been
established for 2,4-dichlorophenol.
輸送方法
UN2020 Chlorophenols, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials
純化方法
Crystallise it from pet ether (b 30-40o). Purify it also by repeated zone melting, using a P2O5 guard tube to exclude moisture. It is very hygroscopic when dry. [Beilstein 6 IV 885.]
不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, and epoxides. Contact with acids or
acid fumes causes decomposition releasing poisonous
chlorine gas. Incompatible with caustics, acid anhydrides;
acid chlorides. Quickly corrodes aluminum; slowly
corrodes zinc, tin, brass, bronze, copper and its alloys. May
accumulate static electrical charges, and may cause ignition
of its vapors.
廃棄物の処理
Dissolve in a combustible
solvent and incinerate in a furnace equipped with afterburner and scrubber. In accordance with 40CFR165,
follow recommendations for the disposal of pesticides and
pesticide containers. Must be disposed properly by following package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office. Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≧100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal
2,4-ジクロロフェノール 上流と下流の製品情報
原材料
準備製品
3-(2,4-ジクロロフェノキシ)-1-プロピン
2-クロロフェノール
(R)-2-(2,4-ジクロロフェノキシ)プロピオン酸
3-(2,4-ジクロロフェノキシ)-6-ニトロ安息香酸メチル
5-chloro-alpha,alpha-bis(3,5-dichloro-2-hydroxyphenyl)-2-toluenesulfonic
オキサジアゾン
2,4-ジクロロ-5-ニトロフェノール
ビチオノール
アザフェニジン
DICLOFOP-METHYL
トリクロサン
2-(2,4-ジクロロフェノキシ)プロピオン酸
2,4-ジクロロフェノキシ酢酸
2,5-ジクロロフェノール
チオりん酸O,O-ジエチルO-(2,4-ジクロロフェニル)
ジチオりん酸O-(2,4-ジクロロフェニル)O-エチルS-プロピル
4-クロロフェノール
ニトロフェン