PDE4D Inhibitor, GEBR-7b - Calbiochem 化学特性,用途語,生産方法
一般的な説明
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC
50 = 0.67 μM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats
in vivo at 100 μM, but has no effect on Aβ levels. This compound elicits cognitive enhancement
in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
PDE4D Inhibitor, GEBR-7b - Calbiochem 上流と下流の製品情報
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