モリシジン

モリシジン 化学構造式
31883-05-3
CAS番号.
31883-05-3
化学名:
モリシジン
别名:
モラシジン;[10-[3-(4-モルホリニル)-1-オキソプロピル]-10H-フェノチアジン-2-イル]カルバミン酸エチル;[10-(3-モルホリノ-1-オキソプロピル)-10H-フェノチアジン-2-イル]カルバミン酸エチル;N-[10-(3-モルホリノプロピオニル)-10H-フェノチアジン-2-イル]カルバミド酸エチル;モリシジン;エチル N-{10-[3-(モルホリン-4-イル)プロパノイル]-10H-フェノチアジン-2-イル}カルバマート
英語名:
Moricizine
英語别名:
Moricizin;Moricizine;TIMTEC-BB SBB005991;Ethmozin:Moricizine;Ethyl (10-(3-Morpholinopropanoyl)-10H-phenothiazin-2-yl)carbaMate;ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;10-(3-Morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester;N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamic acid ethyl ester;N-[10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl]carbamic acid ethyl ester;10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl carbaminoic acid, ethyl ester
CBNumber:
CB4493310
化学式:
C22H25N3O4S
分子量:
427.52
MOL File:
31883-05-3.mol

モリシジン 物理性質

融点 :
156-157°
沸点 :
625.0±55.0 °C(Predicted)
比重(密度) :
1.315±0.06 g/cm3(Predicted)
貯蔵温度 :
-20°C Freezer, Under inert atmosphere
溶解性:
クロロホルム(微量)、メタノール(微量)
酸解離定数(Pka):
6.4(at 25℃)
外見 :
個体
色:
淡いオレンジ色から薄いオレンジ色

安全性情報

モリシジン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

モリシジン 化学特性,用途語,生産方法

効能

抗不整脈薬, 心抑制薬, ナトリウムチャネル遮断薬

使用

Moricizine, is Phenothiazine (P318040) derivative, which It was used as an Antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.

定義

ChEBI: A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group.

一般的な説明

Moricizine, ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate (Ethmozine), is aphenothiazine derivative used for the treatment of malignantventricular arrhythmias. It is categorized as a class ICantiarrhythmic agent, blocking the Na+ channel with 1:1stochiometry. The drug has higher affinity for the inactivatedstate than the activated or resting states. It appearsto bind to a site on the external side of the Na channelmembrane. It has been used to suppress life-threateningventricular arrhythmias.

臨床応用

Moricizine (Ethmozine) is an antiarrhythmic used to treat documented life-threatening arrhythmias.
Moricizine is indicated for the treatment of documented ventricular arrhythmias, particularly sustained ventricular tachycardia. Moricizine was evaluated in the CAST II clinical trial for the prevention of postinfarction ventricular premature complexes. It was ineffective and found to be proarrhythmic. Patients in the moricizine arm of the trial exhibited a greater incidence of sudden cardiac death than did controls.

副作用

The principal adverse gastrointestinal effect of moricizine is nausea (7%). Abdominal discomfort has also been reported. Dizziness (11%) is the most frequently reported CNS-related adverse effect. Such reactions increase in frequency with prolonged drug administration. As with other antiarrhythmic drugs, moricizine has proarrhythmic activity, which may manifest as new ventricular ectopic beats or a worsening of preexisting ventricular arrhythmias. These effects are most common in patients with depressed left ventricular function and a history of congestive heart failure. Cardiovascular effects requiring drug withdrawal include conduction defects, sinus pauses, junctional rhythm, and A-V block.

薬物相互作用

Clinically significant interactions with moricizine do not appear to exist.

予防処置

Patients with preexisting second- or third-degree A-V block, cardiogenic shock, or drug hypersensitivity should not be treated with moricizine.

モリシジン 上流と下流の製品情報

原材料

準備製品


モリシジン 生産企業

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LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2127 70

31883-05-3(モリシジン)キーワード:


  • 31883-05-3
  • TIMTEC-BB SBB005991
  • CARBAMIC ACID, [10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-, ETHYL ESTER
  • Moricizine
  • Moricizin
  • 10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl carbaminoic acid, ethyl ester
  • 10-(3-Morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester
  • Ethmozin:Moricizine
  • N-[10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl]carbamic acid ethyl ester
  • ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
  • N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamic acid ethyl ester
  • Ethyl (10-(3-Morpholinopropanoyl)-10H-phenothiazin-2-yl)carbaMate
  • Carbamic acid, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester
  • モラシジン
  • [10-[3-(4-モルホリニル)-1-オキソプロピル]-10H-フェノチアジン-2-イル]カルバミン酸エチル
  • [10-(3-モルホリノ-1-オキソプロピル)-10H-フェノチアジン-2-イル]カルバミン酸エチル
  • N-[10-(3-モルホリノプロピオニル)-10H-フェノチアジン-2-イル]カルバミド酸エチル
  • モリシジン
  • エチル N-{10-[3-(モルホリン-4-イル)プロパノイル]-10H-フェノチアジン-2-イル}カルバマート
  • 抗不整脈薬
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