NU 2058
NU 2058 物理性質
- 融点 :
- 199°C(lit.)
- 沸点 :
- 424.8±55.0 °C(Predicted)
- 比重(密度) :
- 1.52±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Sealed in dry,2-8°C
- 溶解性:
- DMSO: 22 mg/mL
- 外見 :
- powder to crystal
- 酸解離定数(Pka):
- 7.36±0.20(Predicted)
- 色:
- 白い
- 極大吸収波長 (λmax):
- 281nm(MeOH)(lit.)
- InChIKey:
- MWGXGTJJAOZBNW-UHFFFAOYSA-N
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC3135 |
NU 2058 |
161058-83-9 |
10mg |
￥48000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC3135 |
NU 2058 |
161058-83-9 |
50mg |
￥198000 |
2024-03-01 |
購入 |
|
東京化成工業
|
N0958 |
NU 2058 >98.0%(HPLC)
NU 2058
>98.0%(HPLC) |
161058-83-9 |
20mg |
￥7600 |
2024-03-01 |
購入 |
|
東京化成工業
|
N0958 |
NU 2058 >98.0%(HPLC)
NU 2058
>98.0%(HPLC) |
161058-83-9 |
100mg |
￥26500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
N4286 |
>98% (HPLC)
NU2058 >98% (HPLC) |
161058-83-9 |
5mg |
￥29700 |
2024-03-01 |
購入 |
NU 2058 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
説明
NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC
50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells
in vitro.
使用
NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.
生物活性
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).
NU 2058 上流と下流の製品情報
原材料
準備製品
NU 2058 生産企業
Global( 92)Suppliers
161058-83-9(NU 2058)キーワード:
- 161058-83-9
- 6-(Cyclohexylmethoxy)-9H-purin-2-amine
- 2-aMino-6-purine
- 2-aMino-6-[(cyclohexylMethyl)oxy]purine
- 2-Amino-6-(cyclohexylmethoxy)purine
- CS-2601
- NU 2058;NU-2058;NU2058
- NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE
- NU2058>
- 9H-Purin-2-amine, 6-(cyclohexylmethoxy)-
- O-Cyclohexylmethylguanine
- CDK,NU 2058,guanine-based,inhibit,NU2058,Cyclin dependent kinase,anti-cancer,competitive,Inhibitor,ATP,NU-2058
- NU 2058
- O-シクロヘキシルメチルグアニン