SECO RAPAMYCIN SODIUM SALT 化学特性,用途語,生産方法
説明
Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-
dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-
opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-
2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-
glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.
化学的特性
Yellow Solid
使用
A metabolite of Sirolimus
SECO RAPAMYCIN SODIUM SALT 上流と下流の製品情報
原材料
準備製品