塩酸キンピロール

塩酸キンピロール 化学構造式
85798-08-9
CAS番号.
85798-08-9
化学名:
塩酸キンピロール
别名:
キンピロール·塩酸塩;(4aR)-4,4aα,5,6,7,8,8aβ,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン·塩酸塩;(4aR,8aR)-4,4a,5,6,7,8,8a,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン·塩酸塩;(-)-キンピロール塩酸塩;キンピロール塩酸塩;(-)-キンピロール·塩酸塩;(-)-クインピロール塩酸塩;(−)-キンピロール 塩酸塩;塩酸キンピロール;(4aR)-4,4aα,5,6,7,8,8aβ,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン・塩酸塩;(-)-キンピロール・塩酸塩;(4aR,8aR)-4,4a,5,6,7,8,8a,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン・塩酸塩;キンピロール・塩酸塩;LY-171555
英語名:
(-)-QUINPIROLE HYDROCHLORIDE
英語别名:
LY-171,555;()-Quinpirole;(-)-LY 171555;(4ar-trans)-lorid;(-)-QUINPIROLE HCL;(-)-Quinpirole HCl;(-)-QUINPIROLE HYDROCHLORIDE;(-)-QUINPIROLE HYDROCHLORIDE;(-)-quinpirole monohydrochloride;(-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
CBNumber:
CB4687090
化学式:
C13H22ClN3
分子量:
255.79
MOL File:
85798-08-9.mol
MSDS File:
SDS

塩酸キンピロール 物理性質

貯蔵温度 :
-20°C
溶解性:
0.1 M HCl: 可溶23mg/mL
外見 :
個体
色:
白い
光学活性 (optical activity):
[α]25/D 124.5°, c = 0.4 in H2O(lit.)
安定性::
Hygroscopic

安全性情報

WGK Germany  3
RTECS 番号 UR0809270

塩酸キンピロール 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC1061 (-)-クインピロール塩酸塩
(-)-Quinpirole hydrochloride
85798-08-9 10mg ¥48000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC1061 (-)-クインピロール塩酸塩
(-)-Quinpirole hydrochloride
85798-08-9 50mg ¥205000 2024-03-01 購入
Sigma-Aldrich Japan Q102 (−)-キンピロール 塩酸塩 ≥98% (HPLC), solid
(?)-Quinpirole hydrochloride ≥98% (HPLC), solid
85798-08-9 10mg ¥37200 2024-03-01 購入
Sigma-Aldrich Japan Q102 (−)-キンピロール 塩酸塩 ≥98% (HPLC), solid
(?)-Quinpirole hydrochloride ≥98% (HPLC), solid
85798-08-9 25mg ¥105000 2024-03-01 購入
Sigma-Aldrich Japan Q102 (−)-キンピロール 塩酸塩 ≥98% (HPLC), solid
(?)-Quinpirole hydrochloride ≥98% (HPLC), solid
85798-08-9 100mg ¥223000 2024-03-01 購入

塩酸キンピロール 化学特性,用途語,生産方法

効能

血圧降下薬

使用

(-)-Quinpirole hydrochloride has been used as a selective D2 dopamine (DA) receptor agonist in various experiments.

Biochem/physiol Actions

Quinpirole is a dopamine agonist with high affinity for the D2 and D3 dopamine receptor subtypes. Specific [3H]quinpirole binding in rat brain was saturable, and dependent on temperature, membrane concentration, sodium concentration and guanine nucleotides. The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies. Quinpirole hydrochloride is an active enantiomer of (±)-quinpirole.Saturation analysis revealed high affinity binding characteristics (KD = 2.3 +/- 0.3 nM) which were confirmed by association-dissociation kinetics. The regional distribution of [3H]quinpirole binding sites roughly paralleled the distribution of [3H]spiperone binding sites, with greatest densities present in the striatum, nucleus accumbens and olfactory tubercles. A variety of drugs, most notably monoamine oxidase inhibitors (MAOls), inhibit the binding of [3H]quinpirole, but not [3H]spiperone or [3H](-)N-n-Propylnorapomorphine, in rat striatal membranes by a mechanism that does not appear to involve the enzymatic activity of MAO. Clinically antidepressant MAOIs exhibited selectivity between sites labeled by [3H]quinpirole and [3H]spiperone as did a number of structurally related propargylamines and N-acylethylenediamine derivatives and other drugs such as debrisoquin and phenylbiguanide. The MAOIs clorgyline and Ro 41-1049 were the most potent. MAOIs interact with a novel binding site that is labeled by [3H]quinpirole or that modulates [3H]quinpirole binding. This site may be associated with D2-like dopamine receptors.

塩酸キンピロール 上流と下流の製品情報

原材料

準備製品


塩酸キンピロール 生産企業

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85798-08-9(塩酸キンピロール)キーワード:


  • 85798-08-9
  • (4AR-TRANS)-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G]QUINOLINE HYDROCHLORIDE
  • (-)-QUINPIROLE HCL
  • (-)-QUINPIROLE HYDROCHLORIDE
  • TRANS-(-)-4AR-4,4A,5,6,7,8,8A,9-OCTAHYDRO-5-PROPYL-1H-PYRAZOLO[3,4-G] QUINOLINE HYDROCHLORIDE
  • (4ar-trans)-lorid
  • 4-g)quinolone,4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1h-pyrazolo(monohydroch
  • (-)-QUINPIROLE HYDROCHLORIDE (LY-171555) SELECTIVE D2 DOPAMINE
  • (-)-quinpirole monohydrochloride
  • trans-(–)-(4aR)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline monohydrochloride
  • LY-171,555
  • (4aR,8aR)-5-propyl-1,4,4a,6,7,8,8a,9-octahydropyrazolo[3,4-g]quinoline:hydrochloride
  • ()-Quinpirole
  • (-)-LY 171555
  • (-)-QUINPIROLE HYDROCHLORIDE
  • (-)-Quinpirole HCl
  • 1H-Pyrazolo[3,4-g]quinoline,4,4a,5,6,7,8,8a,9-octahydro-5-propyl-, hydrochloride (1:1), (4aR,8aR)-
  • (4AR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline hydrochloride
  • キンピロール·塩酸塩
  • (4aR)-4,4aα,5,6,7,8,8aβ,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン·塩酸塩
  • (4aR,8aR)-4,4a,5,6,7,8,8a,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン·塩酸塩
  • (-)-キンピロール塩酸塩
  • キンピロール塩酸塩
  • (-)-キンピロール·塩酸塩
  • (-)-クインピロール塩酸塩
  • (−)-キンピロール 塩酸塩
  • 塩酸キンピロール
  • (4aR)-4,4aα,5,6,7,8,8aβ,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン・塩酸塩
  • (-)-キンピロール・塩酸塩
  • (4aR,8aR)-4,4a,5,6,7,8,8a,9-オクタヒドロ-5-プロピル-1H-ピラゾロ[3,4-g]キノリン・塩酸塩
  • キンピロール・塩酸塩
  • LY-171555
  • ドーパミン作動薬
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