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虫草酸

虫草酸 化学構造式
87-78-5
CAS番号.
87-78-5
化学名:
虫草酸
别名:
虫草酸;グルコース 2
英語化学名:
Mannitol
英語别名:
Maitol;MANNITOL;NSC 9256;CB4720971;MANNITOL B;DL-Mannitol;MANNITOL BP;MANNITOL USP;Mannidex 16700;MANNITOL USP/BP
CBNumber:
CB4720971
化学式:
C6H14O6
分子量:
182.17
MOL File:
87-78-5.mol

虫草酸 物理性質

融点 :
167°C
沸点 :
494.9°C
比重(密度) :
1.596
屈折率 :
1.5970 (estimate)
貯蔵温度 :
Inert atmosphere,Room Temperature
酸解離定数(Pka):
pKa 13.50(H2O,t =18)(Approximate)
水溶解度 :
177.3g/L(25 ºC)
CAS データベース:
87-78-5(CAS DataBase Reference)
EPAの化学物質情報:
Mannitol (87-78-5)

安全性情報

HSコード  29054300

虫草酸 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

虫草酸 化学特性,用途語,生産方法

定義

本品は、次の化学式で表される糖アルコールである。

化粧品の成分用途

保湿.湿潤剤、保水剤、結合剤、香味剤

説明

It can be used to lower intraocular pressure and in the postoperational period in ophthalomological procedures as well as during brain edema.

化学的特性

D-mannitol (D-mannohexan-1.2.3.4.5.6-hexaol) is a constituent of several plants including the Manna ash, several edible plants, and seaweed. Parts of the latter contain up to 10 % mannitol by weight. The solubility in water is approximately 230 g/L at room temperature and it increases with increasing temperature. Mannitol is stable under the common processing conditions of foods.
Mannitol is approximately 50 % as sweet as sucrose and non-cariogenic. In the European Union, maltitol is approved as E 421 for a large number of food applications. In the United States, mannitol produced by hydrogenation of glucose or fructose solutions or by fermentation by Zygosaccharomyces rouxii or Lactobacillus intermedius is approved for several food applications. It is also approved in many other countries.

使用

Mannitol is a polyol (polyhydric alcohol) produced from hydrogena- tion from fructose that functions as a sweetener, humectant, and bulking agent. it has low hygroscopicity and poor oil solvency. it has 1.6 kcal/g. it is approximately 22% soluble in water and is approximately 72% as sweet as sugar, exhibiting a cool, sweet taste. it functions as a dusting agent with starch in chewing gum. it is used in sugarless candy, chewing gum, cereal, and pressed mints.

定義

A soluble hexahydric alcohol that occurs in many plants and fungi. It is used in medicines and as a sweetener (particularly in foods for diabetics). It is an isomer of sorbitol.

定義

mannitol: A polyhydric alcohol,CH2OH(CHOH)4CH2OH, derived frommannose or fructose. It is the mainsoluble sugar in fungi and an importantcarbohydrate reserve in brownalgae. Mannitol is used as a sweetenerin certain foodstuffs and as a diureticto relieve fluid retention.

Biotechnological Production

The by far largest quantity of mannitol is produced by chemical hydrogenation of fructose which yields a mixture of mannitol and sorbitol. The mixture is subjected to fractionated crystallization. As direct sorbitol production is less costly, the processing costs have mostly to be borne by mannitol which makes it more expensive than sorbitol. Production from seaweed seems to be of limited importance.
Possibilities to produce mannitol by fermentation were studied using several organisms. They mostly use fructose as an acceptor for hydrogen and glucose as a source of carbon. In a fed-batch culture of C. magnoliae with 50 g/L of glucose as the initial carbon source and increasing levels of fructose up to 300 g/L in 120 h, 248 g/L of mannitol were obtained from 300 g/L of fructose equivalent to a conversion rate of 83 % and a productivity of 2.07 g/Lh. High yields were obtained from Lactobacillus fermentum grown in a batch reactor. The conversion rates increased from 25 to 35 C to 93.6 % with average and high productivities of 7.6 and 16.0 g/Lh. A fast mannitol production of 104 g/L within 16 h was obtained from L. intermedius on molasses and fructose syrups in a concentration of 150 g/L with a fructose-to-glucose rate of 4:1. High productivity (26.2 g/Lh) and conversion rates (97 mol%) were obtained in a high cell density membrane cell recycle bioreactor. Increase of the fructose concentration above 100 g/L reduced the productivity. A fed-batch process with L. intermedius yielded 176 g/L of mannitol from 184 g/L fructose and 94 g/L glucose within 30 h. The productivity of 5.6 g/Lh could be increased to more than 40 g/Lh at the expense of reduced mannitol yield and increased residual substrate concentrations.
As mannitol is more expensive than sorbitol, production by fermentation may become an alternative to hydrogenation of fructose.

作用機序

Today, mannitol is the most widely used osmotic diuretic. It raises osmotic pressure in renal tubules, thus reducing reabsorption of water in the nephrons. As a result, a large quantity of free water is released, sodium secretion increases, and as a rule, an insignificant amount of potassium is secreted. Mannitol is used as an adjuvant drug for preventing oliguria and anuriua.

臨床応用

Mannitol is the agent most commonly used as an osmotic diuretic. Sorbitol also can be used for similar reasons.Mannitol is administered intravenously in solutions of 5 to 50% at a rate of administration that is adjusted to maintain the urinary output at 30 to 50 ml/hour. Mannitol is filtered at the glomerulus and is poorly reabsorbed by the kidney tubule. The osmotic effect of mannitol in the tubule inhibits the reabsorption of water, and the rate of urine flow can be maintained. It also is used to reduce intracranial pressure by reducing cerebral intravascular volume.

安全性プロファイル

A poison by intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Veterinary Drugs and Treatments

Mannitol is used to promote diuresis in acute oliguric renal failure, reduce intraocular and intracerebral pressures, enhance urinary excretion of some toxins, (e.g., aspirin, some barbiturates, bromides, ethylene glycol) and, in conjunction with other diuretics, to rapidly reduce edema or ascites when appropriate (see Contraindications- Precautions below). In humans, it is also used as an irrigating solution during transurethral prostatic resections.

虫草酸 上流と下流の製品情報

原材料

準備製品


虫草酸 生産企業

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87-78-5(虫草酸)キーワード:


  • 87-78-5
  • MANNITOL
  • Maitol
  • CB4720971
  • DL-Mannitol
  • Hexahydroxyhexane
  • Cordycepin 10% Mannitol
  • MANNITOL USP
  • MANNITOL USP/BP
  • MANNITOL PYROGEN FREE USP24
  • MANNITOL PYROGEN FREE USP.
  • MANNITOL B
  • MANNITOL USP 24
  • N.F,USP MANNITOL
  • MANNITOL BP
  • MANNITOL, CP2000/BP2000/USP23
  • Mannidex 16700
  • Mannitol (8CI, 9CI)
  • NSC 9256
  • D-glycero-Hexitol
  • Mannitol###D-Mannitol
  • Mannitol, 98%, from Phaeophyta
  • mannitol crystalline powder
  • Mannitol crystals
  • Mannitol/Mannitol powder
  • Mannitol USP/EP/BP
  • Mannitol CAS 87 78 5
  • 虫草酸
  • グルコース 2
  • マンニトール
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