スルファジアジン銀
スルファジアジン銀 物理性質
- 融点 :
- 285 °C (dec.)(lit.)
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,Room temperature
- 溶解性:
- DMSO（微量、加熱）、メタノール（微量）
- 外見 :
- 粉
- 色:
- ホワイトからオフホワイト
- Merck :
- 14,8903
- 安定性：:
- 安定。強力な酸化剤とは相容れない。
- InChIKey:
- UEJSSZHHYBHCEL-UHFFFAOYSA-N
- CAS データベース:
- 22199-08-2(CAS DataBase Reference)
スルファジアジン銀 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01USP1612608 |
銀スルファジアジン
Silver Sulfadiazine |
22199-08-2 |
200mg |
￥119700 |
2024-03-01 |
購入 |
|
東京化成工業
|
S0595 |
スルファジアジン銀 >98.0%(HPLC)(T)
Silver Sulfadiazine
>98.0%(HPLC)(T) |
22199-08-2 |
5g |
￥7000 |
2024-03-01 |
購入 |
|
東京化成工業
|
S0595 |
スルファジアジン銀 >98.0%(HPLC)(T)
Silver Sulfadiazine
>98.0%(HPLC)(T) |
22199-08-2 |
25g |
￥21500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
PHR2654 |
銀(I)スルファジアジン Pharmaceutical Secondary Standard; Certified Reference Material
Silver sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material |
22199-08-2 |
500MG |
￥37300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
481181 |
銀(I)スルファジアジン 98%
Silver(I) sulfadiazine 98% |
22199-08-2 |
5g |
￥6300 |
2024-03-01 |
購入 |
スルファジアジン銀 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
効能
外用抗菌薬, 葉酸合成阻害薬
商品名
ゲーベン (田辺三菱製薬)
化学的特性
solid
使用
Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.
適応症
Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial
properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell
wall. It is used primarily as an adjunct in the prevention and treatment of wound
sepsis in patients with second- and third-degree burns and for wound care of chronic
ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as
well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those
sensitive to silver nitrate but resistant to sulfadiazine, have shown good response
to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance,
and does not cause systemic acidosis. Some patients note a stinging sensation on
application, and because this compound can be absorbed, systemic sulfonamide
reactions similar to those caused by sulfonamides may occur.
応用例（製薬）
Silver sulfadiazine is extremely insoluble. In addition to the
usual activity of sulfonamides it exhibits activity – almost certainly
attributable to the silver component – against Ps. aeruginosa
and some fungi.
It is variably absorbed after topical application depending
on the integrity of the skin. Toxic concentrations may
be achieved in patients with extensive burns. It is used topically,
mainly for burns, pressure sores and leg ulcers. Central
venous catheters impregnated with chlorhexidine and silver
sulfadiazine have been developed to reduce bacterial colonization.
Other suggested uses include the prevention of
infection in skin graft donor sites and cord care in newborn
infants.
臨床応用
The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.
スルファジアジン銀 上流と下流の製品情報
原材料
準備製品
スルファジアジン銀 生産企業
Global( 376)Suppliers
22199-08-2(スルファジアジン銀)キーワード:
- 22199-08-2
- silver (4-aminophenyl)sulfonyl-pyrimidin-2-yl-azanide
- SILVER SULFADIAZINE
- SULPHADIAZINE-AG
- 4-amino-n-(2-pyrimidinyl)benzenesulfonamidesilversalt
- 4-amino-n-2-pyrimidinylbenzenesulfonamide monosilver salt
- (4-amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver
- [4-Amino-N-(2-pyrimidinyl-kN1)benzenesulfonamidato-kO]silver
- 4-Amino-N-2-pyrimidinylbenzenesulfonamide Silver Complex
- Dermazin
- Flammazine
- Silver, 4-amino-N-(2-pyrimidinyl-.kappa.N1)benzenesulfonamidato-.kappa.O-
- SILVERSULFADIAZINE,MICRONIZED
- SILVERSULFADIAZINE,MICRONIZED,USP
- sulfadiazine silver，SD-Ag
- Sulfadiazine,Siliver salt
- 4-Amino-N-2-pyrimidinylbenzenesulfonamide monosilver(1+) salt
- Sulfadiazine sailver salt
- Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex
- Nsc625324
- Silver,(4-amino-N-2-pyrimidinylbenzenesulfonamidato-nn,o1)-
- Sulfadiazine silversilvadene
- Silver Sulfdiazine
- SD-Ag
- Silver Sulfadiazine (200 mg)
- 3-(4-aMinophenyl)-3-oxo-1H,4H-2$l^{3},3$l^{6},4,5,9000000$l^{5},1-pyriMido[2,1-d]1$l^{3}-oxa-2$l^{6}-thia-3,5$l^{5}-diaza-6-argentacyclohexan-1-yliuM-4-id-9-yl
- SILVER(I) SULFADIAZINE 98%
- Silver suifadiazine
- Silver,[4-aMino-N-(2-pyriMidinyl-kN1)benzenesulfonaMidato-kO]-
- 4-amino-n-2-pyrimidinyl-benzenesulfonamidmonosilver(1+)salt
- dermazine
- スルファジアジン銀
- 銀スルファジアジン
- ゲーベン
- ゲーベンクリーム
- スルファジアジン·銀(I)
- 銀(I)スルファジアジン
- スルファジアジン銀 (JP17)
- スルファジアジン・銀(I)
- 構造分類
- 合成抗菌剤
- 金属別化合物
- 遷移金属化合物
- 生化学
- 試験研究用抗菌剤
- 銀化合物
- サルファ剤 (試験研究用合成抗菌剤)
- サルファ剤
- 皮膚用薬