タンドスピロン
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- CAS番号.
- 87760-53-0
- 化学名:
- タンドスピロン
- 别名:
- (1R,2S,6R,7S)-4-{4-[4-(ピリミジン-2-イル)ピペラジン-1-イル]ブチル}-4-アザトリシクロ[5.2.1.02,6]デカン-3,5-ジオン
- 英語名:
- Tandospirone
- 英語别名:
- (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione;Sediel;TANDOSPIRONE;(3aR,4S,7R,7aS)-rel-;Tandospirone (SM3997);Tandospirone [inn:ban];TANDOSPIRONE USP/EP/BP;Tandospirone hydrochloride;3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione;(1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt
- CBNumber:
- CB4796484
- 化学式:
- C21H29N5O2
- 分子量:
- 383.49
- MOL File:
- 87760-53-0.mol
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タンドスピロン 物理性質
- 融点 :
- 112-113.5°
- 沸点 :
- 613.9±65.0 °C(Predicted)
- 比重(密度) :
- 1.239±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Store at +4°C
- 溶解性:
- DMSO：可溶38mg/mL
- 酸解離定数(Pka):
- 7.71±0.10(Predicted)
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCT006430 |
タンドスピロン
Tandospirone |
87760-53-0 |
25mg |
￥88200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
T6704 |
タンドスピロン ≥98% (HPLC)
Tandospirone ≥98% (HPLC) |
87760-53-0 |
5mg |
￥28100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
T6704 |
タンドスピロン ≥98% (HPLC)
Tandospirone ≥98% (HPLC) |
87760-53-0 |
25mg |
￥98900 |
2024-03-01 |
購入 |
タンドスピロン 化学特性,用途語,生産方法
効能
抗不安薬, トランキライザー, セロトニン5-HT1A受容体作動薬
説明
Tandospirone is another 5-HT1A receptor agonist under development by Sumitomo Pharmaceutical Co., Ltd., in Japan and Pfizer in the United States. Results of phase II and phase III clinical trials show that tandospirone is effective for the treatment of anxiety neurosis. Significant improvement is also observed in patients with psychosomatic disease, phobia, and depersonalization (Murasaki 1995). The results have shown that initial treatment should be started at 30 mg daily, and the dose should be increased up to 60 mg daily according to symptoms (Murasaki 1995). A double-blind comparative study with diazepam revealed that tandospirone tends to be superior to diazepam in patients with depressive neurosis, whereas diazepam may be more effective than tandospirone in severely ill patients (Murasaki et al. 1992).
使用
Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
生物活性
5-HT 1A receptor partial agonist (K i = 27 nM) that displays selectivity over 5-HT 2 , 5-HT 1C , α 1 , α 2 , D 1 and D 2 receptors (K i values ranging from 1300-41000 nM). Inactive at 5-HT uptake sites, 5-HT 1B , β -adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
タンドスピロン 上流と下流の製品情報
原材料
準備製品
タンドスピロン 生産企業
Global( 105)Suppliers
87760-53-0(タンドスピロン)キーワード:
- 87760-53-0
- TANDOSPIRONE
- 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-
- 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel- (9CI)
- (3αα，4β，7β，7αα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4，7-methano-1H-isoindole-1，3(2H)-dione
- Sediel
- Tandospirone [inn:ban]
- (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride
- Tandospirone hydrochloride
- 3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione
- (3aR,4S,7R,7aS)-rel-
- 4,7-Methano-1H-isoindole-1,3(2H)-dione,hexahydro-2-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-
- (1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt
- 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aα,4β,7β,7aα)-
- TANDOSPIRONE USP/EP/BP
- rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
- Tandospirone (SM3997)
- (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
- (1R,2S,6R,7S)-4-{4-[4-(ピリミジン-2-イル)ピペラジン-1-イル]ブチル}-4-アザトリシクロ[5.2.1.02,6]デカン-3,5-ジオン