イソシアン酸フェニル 化学特性,用途語,生産方法
用途
脱水剤,ウレタン原料,アルコール?フェノール類の確認試薬 (NITE CHRIP)
化学的特性
Phenyl isocyanate is a colorless liquid with an irritating odor.
使用
Phenyl Isocyanate is also used in the synthesis of cyanopyridine derivatives in the search for anticancer compounds. It is also used in the synthesis of aminobenzimidazole derivatives with phenylcyclohexyl acetic groups showing antiobesity-antidiabetic activity.
製造方法
To a mixture of aniline hydrochloride (12.95 g, 0.1 mol) and dry dioxane (100 mL) was added diphosgene (6.3 mL, 10.4 g, 0.05 mol). The mixture was heated to 60 °C; after stirring for 1.5 h, it became a clear solution. Heating was stopped after 3.5 h and the solvent was removed under reduced pressure. The residue was distilled at 70–73.5 °C (36 mmHg) to give 10.6 g (89%) of phenyl isocyanate. It could be redistilled almost quantitatively, bp 75–77 °C(39 mmHg) or 55–57 °C(16 mmHg).
定義
ChEBI: An isocyanate composed of a benzene ring bearing a single isocyanato substituent.
一般的な説明
A colorless liquid. About the same density as water. Very toxic by ingestion, inhalation or skin absorption. Very irritating to skin, eyes and mucous membranes. Flash point 132°F.
空気と水の反応
Flammable. Decomposes in water.
反応プロフィール
Isocyanates and thioisocyanates, such as Phenyl isocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol. Phenyl isocyanate, cobalt pentamine triazo perchlorate, and nitrosyl perchlorate mixture was stirred for 2-3 minutes. When the stirring was interrupted, the mixture exploded [Chem. Eng. News 46(8):39. 1968].
健康ハザード
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
火災危険
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
安全性プロファイル
A poison. An irritant. Mutation data reported. Flammable liquid when exposed to heat or flame; can react vigorously with oxidizing materials. Has exploded when stirred with (cobalt pentammine triazoperchlorate + nitrosyl perchlorate). When heated to decomposition it emits toxic fumes of CNand NOx. See also CYANATES.
職業ばく露
Phenyl isocyanate is used as a laboratory reagent and in organic synthesis
輸送方法
UN2487 Phenyl isocyanate, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 3-Flammable liquid
純化方法
Distil phenylisocyanate under reduced pressure from P2O5. [Beilstein 12 IV 864.]
不和合性
May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents, urethanes, ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acyl-chlorides may cause explosive polymerization. Contact with metals may evolve flammable hydrogen gas. Attacks some plastics, rubber and coatings. Contact with metals may evolve flammable hydrogen gas. May accumulate static electrical charges, and may cause ignition of its vapors.
イソシアン酸フェニル 上流と下流の製品情報
原材料
準備製品
N'-(4-イソプロピルフェニル)-N,N-ジメチル尿素
1-(4-ニトロフェニル)-3-(3-ピリジルメチル)尿素
N-フェニルカルバミド酸プロピル
4-アミノベンゾトリフルオリド
1,3-ジフェニル尿素
2-(3-ヒドロキシ-2-キノリニル)-1,3-インダンジオン
4-フェニルウラゾール
1-(4-クロロベンジル)-1-シクロペンチル-3-フェニル尿素
fluorescent bleaches R
ニルタミド
1-(2-クロロ-4-ピリジル)-3-フェニルウレア
N-フェニル-N'-(1,2,3-チアジアゾール-5-イル)尿素
2-メチル-3-キノリノール
N-[[3,5-ジクロロ-4-(1,1,2,2-テトラフルオロエトキシ)フェニル]カルバモイル]-2,6-ジフルオロベンズアミド
3-メチル-4-イソオキサゾールカルボン酸
fluorescent bleaches BR
(R)-N-エチル-2-[[(フェニルアミノ)カルボニル]オキシ]プロパンアミド
フェニルカルバミン酸ブチル
3-(3-クロロ-p-トリル)-1,1-ジメチル尿素