1-ヘキサデカノール 化学特性,用途語,生産方法
外観
白色の粒状
定義
本品は、次の化学式で表される脂肪族アルコールである。
溶解性
エタノール及びアセトンに溶け、水にほとんど溶けない。
解説
C16H34O(242.45)．CH3(CH2)14CH2OH．1-ヘキサデカノールともいう．パルミチン酸エステルとして鯨ろうやイルカ油などのなかに存在し，このパルミチン酸エステルをけん化すると得られる．無色，無臭の結晶性固体．融点49 ℃，沸点344 ℃(101 kPa)，190 ℃(2.0 kPa)．
"0.811．水に不溶，エタノール，エーテル，クロロホルム，ベンゼンなどに可溶．軟膏基剤，化粧クリーム，ローションなどに用いられる．[CAS 36653-82-4]
森北出版「化学辞典（第2版）
用途
有機合成原料、医薬原料
原料由来
飽和高級アルコール（植物系のみ）
化粧品の成分用途
不透明化剤、非水系増粘剤、起泡剤、親水性増粘剤、乳化安定剤、乳化剤、香料
効能
乳化剤, 硬化剤
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。C14の組成割合が他のセタノールより多く、使用感に違いが出る。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。C16の高純度タイプ。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。セタノールの組成割合を若干変えた汎用タイプ。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。臭いを抑え、組成割合を変えたタイプのセタノール。C16:約50%。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。臭いを抑え、組成割合を変えたタイプのセタノール。C16:約70%。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。臭いを抑えた標準タイプのセタノール。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。当社セタノールの標準タイプ。
特徴
パーム・ヤシ由来の飽和高級アルコール。乳化物の安定化剤、過脂肪剤。様々な処方への応用が可能。日本薬局方適合品。
特徴
高純度の飽和高級アルコール。
説明
1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.
化学的特性
Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or
castings. It has a faint characteristic odor and bland taste.
天然物の起源
Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw
使用
1-Hexadecanol has been used in preparation of:
(±)-2-methoxyheptadecanoic acid (fatty acid)
high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1
定義
ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.
調製方法
Cetyl alcohol may be manufactured by a number of methods such as
esterification and hydrogenolysis of fatty acids or by catalytic
hydrogenation of the triglycerides obtained from coconut oil or
tallow. Cetyl alcohol may be purified by crystallization and
distillation.
一般的な説明
1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.
安全性
Cetyl alcohol is mainly used in topical formulations, although it has
also been used in oral and rectal preparations.
Cetyl alcohol has been associated with allergic delayed-type
hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization
with cetostearyl alcohol, lanolin, and stearyl alcohol
has also been reported. It has been suggested that hypersensitivity
may be caused by impurities in commercial grades of cetyl
alcohol since highly refined cetyl alcohol (99.5%) has not been
associated with hypersensitivity reactions.
LD
50 (mouse, IP): 1.6 g/kg
LD
50 (mouse, oral): 3.2 g/kg
LD
50 (rat, IP): 1.6 g/kg
LD
50 (rat, oral): 5 g/kg
貯蔵
Cetyl alcohol is stable in the presence of acids, alkalis, light, and air;
it does not become rancid. It should be stored in a well-closed
container in a cool, dry place.
純化方法
Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]
不和合性
Incompatible with strong oxidizing agents. Cetyl alcohol is
responsible for lowering the melting point of ibuprofen, which
results in sticking tendencies during the process of film coating
ibuprofen crystals.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (ophthalmic
preparations, oral capsules and tablets, otic and rectal preparations,
topical aerosols, creams, emulsions, ointments and solutions, and
vaginal preparations). Included in nonparenteral medicines licensed
in the UK. Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
1-ヘキサデカノール 上流と下流の製品情報
原材料
準備製品