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2-ブタノン

2-ブタノン 化学構造式
78-93-3
CAS番号.
78-93-3
化学名:
2-ブタノン
别名:
2-ブタノン;メチルエチルケトン;(メチル)エチルケトン;エチル(メチル)ケトン;エチルメチルケトン;メチル(エチル)ケトン;1-メチルプロピオンアルデヒド;ブタノン;ブタン-2-オン;2ブタノン;MEK;メチルエチルケトン(2-ブタノン);2-ブタノン [吸光分析用];2‐ブタノン;2-ブタノン ACS REAGENT,≥99.0%;2-ブタノン PURISS. P.A.,ACS REAGENT,≥99.5% (GC);2-ブタノン PURISS. P.A.,ACS REAGENT,REAG. PH. EUR.,≥99.5% (GC);2-ブタノン REAGENTPLUS,≥99%;2-ブタノン クロマソルブ,FOR HPLC,≥99.7%;2-ブタノン メチルエチルケトン
英語化学名:
2-Butanone
英語别名:
MEK;Meetco;Butanon;BUTANONE;Meketone;OMNISOLV;2-Butanon;2-butanal;FEMA 2170;C2H5COCH3
CBNumber:
CB4854386
化学式:
C4H8O
分子量:
72.11
MOL File:
78-93-3.mol

2-ブタノン 物理性質

融点 :
-87 °C
沸点 :
80 °C(lit.)
比重(密度) :
0.806
蒸気密度:
2.49 (vs air)
蒸気圧:
71 mm Hg ( 20 °C)
屈折率 :
n20/D 1.379(lit.)
FEMA :
2170 | 2-BUTANONE
闪点 :
26 °F
貯蔵温度 :
2-8°C
溶解性:
Miscible with acetone, ethanol, benzene, ether (U.S. EPA, 1985), and many other solvents, particularly ketones and aldehydes
酸解離定数(Pka):
14.7 (quoted, Riddick et al., 1986)
外見 :
Solution
色:
Colorless
臭い (Odor):
Sweet/sharp odor detectable at 2 to 85 ppm (mean = 16 ppm)
PH:
pH(1+4, 25℃):6.0~7.0
Relative polarity:
0.327
臭気閾値(Odor Threshold):
0.44ppm
爆発限界(explosive limit):
1.8-11.5%(V)
水溶解度 :
290 g/L (20 ºC)
Merck :
14,6072
JECFA Number:
278
BRN :
741880
Henry's Law Constant:
23.0 at 50.00 °C, 34.1 at 60.00 °C, 50.6 at 70.00 °C, 70.4 at 80.00 °C (headspace-GC, Hovorka et al., 2002)
暴露限界値:
TLV-TWA, PEL 590 mg/m3 (200 ppm) (ACGIH, OSHA); STEL 885 mg/m3 (300 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).
安定性::
Stable. Highly flammable. Incompatible with oxidizing agents, bases, strong reducing agents. Protect from moisture.
CAS データベース:
78-93-3(CAS DataBase Reference)
NISTの化学物質情報:
2-Butanone(78-93-3)
EPAの化学物質情報:
Methyl ethyl ketone (78-93-3)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,Xi,T
Rフレーズ  11-36-66-67-39/23/24/25-23/24/25
Sフレーズ  9-16-45-36/37
RIDADR  UN 1193 3/PG 2
WGK Germany  1
RTECS 番号 EL6475000
自然発火温度 516 °C
TSCA  Yes
国連危険物分類  3
容器等級  II
HSコード  29141200
有毒物質データの 78-93-3(Hazardous Substances Data)
毒性 LD50 orally in rats: 6.86 ml/kg (Smyth)
消防法 危険物第4類第一石油類(非水溶性)
化審法 優先評価化学物質
安衛法 有機溶剤中毒予防規則:第2種有機溶剤,57,57-2
毒劇物取締法 III
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H336 眠気やめまいのおそれ 特定標的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

2-ブタノン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

2-ブタノン MSDS


2-Butanone

2-ブタノン 化学特性,用途語,生産方法

外観

無色澄明の液体

定義

MEKは、メチルエチルケトンの表示名称である。本品は、次の化学式で表される脂肪族ケトンである。

溶解性

エタノール及びジエチルエーテルに極めて溶けやすく、水に溶けやすい。

用途

硝酸セルロース及び各種合成樹脂、ラッカー用溶剤、ブナN用接着剤、印刷インキ用、人造皮革、潤滑油精製用溶剤、加硫促進剤、中間物、洗浄剤化粧品原料(爪化粧品)

化粧品の成分用途

溶剤、香料

主な用途/役割

溶剤型接着剤に使用される。

使用上の注意

不活性ガス封入

説明

2-Butanone is a stable, highly flammable chemical. It is incompatible with oxidising agents, bases, and strong reducing agents. It is a colourless liquid with a sharp, sweet odour. 2-Butanone is produced in large quantities. It is used as a solvent and nearly half of its use is in paints and other coatings because it will quickly evaporate into the air and it dissolves many substances. It is also used in glues and as a cleaning agent.

化学的特性

Methyl ethyl ketone (MEK) is a colorless liquid with an odor that has been described as moderately sharp, fragrant, peppermint, or acetone like. It soluble in water up to 28% by weight and is miscible with many other organic solvents. The lower explosive limit is 1.4% and the upper explosive limit is 11.4%. Methyl ethyl ketone may be incompatible with strong oxidizers, amines, ammonia, inorganic acids, caustics, isocyanates, and pyridines. When used industrially, methyl ethyl ketone must be handled with caution, as it is a Class lB flammable liquid NIOSH (2010).

物理的性質

2-Butanone is a clear, colorless, volatile, very flammable liquid with a sweet, mint or acetone-like odor. Odor threshold concentration is 10.0 ppmv (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 5.8 mg/m3 (2.0 ppmv) and 16 mg/m3 (5.4 ppmv), respectively (Hellman and Small, 1974). It is incompatible with oxidizing agents, bases, and strong reducing agents. It is a colorless liquid with a sharp, sweet odor. 2-Butanone is produced in large quantities. It is used as a solvent and nearly half of its use is in paints and other coatings because it quickly evaporates into the air and it dissolves many substances. It is also used in glues and as a cleaning agent.

天然物の起源

Reported found as an impurity among products from the dry distillation of wood and in the oil (extracted with ether) of black tea; it is also present in coffee, cheese, bread, some citrus oils and some other natural products (grape, raspberry).

使用

2-Butanone is an eye irritant that has been used as a water soluble photoinitiator for the photopolymerization of methacrylic acid (MAA). As solvent; in the surface coating industry; manufacture of smokeless powder; colorless synthetic resins.

使用

Methyl ethyl ketone (2-butanone, ethyl methyl ketone, methyl acetone) is an organic solvent of relatively low toxicity, which is found in many applications. It is used in industrial and commercial products as a solvent for adhesives, paints, and cleaning agents and as a de-waxing solvent. A natural component of some foods, methyl ethyl ketone can be released into the environment by volcanoes and forest fires.It is used in themanufacture of smokeless powder and colorless synthetic resins, as a solvent, and insurface coating. It is also used as a flavoringsubstance in food.

製造方法

By catalytic dehydrogenation of secondary butyl alcohol; by dehydration of butane-2,3-diol by refluxing with 25% aqueous H2SO4. Industrially, it is also prepared by controlled oxidation of butane, by dry distillation of calcium acetate and calcium propionate, or by refluxing methyl acetoacetate and diluted H2SO4.

調製方法

Methyl ethyl ketone is commercially manufactured from nbutene in a metal-catalyzed hydrogenation reaction that proceeds through the intermediate formation of 2-butanol . A second method of synthesis involves the liquid- phase oxidation of n-butane with the formation of acetic acid as a coproduct.

定義

A colorless volatile liquid ketone. It is manufactured by the oxidation of butane and used as a solvent.

定義

ChEBI: A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2.

Taste threshold values

Taste characteristics at 5 ppm: chemical-like and slightly fruity green.

一般的な説明

Methyl ethyl ketone (MEK) is a colourless liquid with a sweet and sharp odour. It is soluble in alcohol, ether, acetone benzene, and water. It is a solvent often found in mixtures with acetone, ethyl acetate, n-hexane, toluene, or alcohols. It has applications in the surface coating industry and in the de-waxing of lubricating oils. MEK is used in the manufacture of colourless synthetic resins, artificial leather, rubbers, lacquers, varnishes, and glues.

空気と水の反応

Highly flammable. Slightly soluble in water.

反応プロフィール

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

危険性

Flammable, dangerous fire risk. Toxic by ingestion.

健康ハザード

Occupational workers are exposed to 2-butanone by breathing contaminated air in workplaces associated with the production or use of paints, glues, coatings, or cleaning agents. Prolonged exposures to 2-butanone cause symptoms of poisoning such as cough, dizziness, drowsiness, headache, nausea, vomiting, dermatitis, irritation of the nose, throat, skin, and eyes and at very high levels cause drooping eyelids, uncoordinated muscle movements, loss of consciousness, and birth defects. Chronic inhalation studies in animals have reported slight neurological, liver, kidney, and respiratory effects. However, information on the chronic (long-term) effects of 2-butanone (methyl ethyl ketone) in humans is limited.

健康ハザード

The acute toxicity of methyl ethyl ketone is low. Exposure to high concentrations can cause headache, dizziness, drowsiness, vomiting, and numbness of the extremities. Irritation of the eyes, nose, and throat can also occur. Methyl ethyl ketone is considered to have adequate warning properties.
Repeated or prolonged skin exposure to methyl ethyl ketone can cause defatting of the skin, leading to cracking, secondary infection, and dermatitis. This compound has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans. Methyl ethyl ketone has exhibited developmental toxicity in some animal tests

火災危険

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

燃焼性と爆発性

Methyl ethyl ketone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." MEK vapor forms explosive mixtures with air at concentrations of 1.9 to 11% (by volume). Carbon dioxide or dry chemical extinguishers should be used for MEK fires.

化学反応性

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

薬理学

Anticonvulsant activity was demonstrated in rats given orally a dose of 805 mg MEK/kg, which significantly delayed the onset of isonicotinic acid hydrazide-induced convulsions and provided 60% protection against electroshock convulsions, but failed to protect against metrazole convulsions (Kohli, Kishor, Dua & Saxena, 1967). Golubev (1969) reported that 0.25 M-MEK caused contraction of the rabbit pupil, and MEK and other volatile substances isolated from human urine and injected iv into rabbits damaged cerebral and coronary arteries and caused increased capillary permeability, but did not alter the blood-sugar level (Mabuchi, 1969). In dogs, MEK caused vomiting, muscular debility and the formation of large quantities of urinary magnesium ammonium phosphate crystals (Verstraete, van der Stock & Mattheeuws, 1964).
Combined ip administration of MBK and MEK (1:3) to guinea-pigs increased the urinary excretion of the MBK metabolites 2-hexanol and 2,5-hexanedione (Couri, Abdel-Rahman & Hetland, 1976). If the neurotoxic action of MBK is mediated by a metabolite, stimulation of MBK metabolism by simultaneous exposure to MEK may help to explain the marked enhancement of neurotoxicity that is observed with combined MBK/MEK exposures (Hetland et al. 1976).

安全性プロファイル

Moderately toxic by ingestion, skin contact, and intraperitoneal routes. Human systemic effects by inhalation: conjunctiva irritation and unspecified effects on the nose and respiratory system. An experimental teratogen. A strong irritant. Human eye irritation @ 350 ppm. Affects peripheral nervous system and central nervous system. Highly flammable liquid. Reaction with hydrogen peroxide + nitric acid forms a heatand shock-sensitive explosive product. Ignition on contact with potassium tert-butoxide. Mixture with 2- propanol will produce explosive peroxides during storage. Vigorous reaction with chloroform + alkali. Incompatible with chlorosulfonic acid, oleum. To fight fire, use alcohol foam, CO2, dry chemical. Used in production of drugs of abuse. When heated to decomposition it emits acrid smoke and fumes.

職業ばく露

MEK is used as a solvent in nitrocellulose coating and vinyl film manufacture; in smokeless powder manufacture; in cements and adhesives and in the dewaxing of lubricating oils. It is also an intermediate in drug manufacture

Carcinogenicity

Although MEK has not been specifically examined in a rodent 2-year bioassay, there is little to suggest that the material is carcinogenic. When used as a delivery vehicle in a dermal carcinogenicity bioassay for organic sulfur compounds, Horton et al. found that the application of benzyl disulfide or phenylbenzylthiophene in a 25–29% solution of MEK in dodecylbenzene together failed to increase the incidence of benign skin papillomas in male C3H/HeJmice. The mice used in the experiments were treated twice a week for 52 weeks with the MEKcontaining test solution.

Source

Improper disposal of cleaning fluids, adhesives, paints, and lacquers, and laboratory solvent. Leaches from PVC cement used to join tubing (Wang and Bricker, 1979). Also present in cigarette smoke (500 ppm) and exhaust from gasoline-powered engines (<0.1–2.6 ppm) (Verschueren, 1983).
Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered automobiles with and without catalytic converters were 0.47 and 32 mg/km, respectively (Schauer et al., 2002).
Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of 2-butanone were 215 mg/kg of pine burned, 115 mg/kg of oak burned, and 77 mg/kg of eucalyptus burned.

環境運命予測

Biological. Following a lag time of approximately 5 h, 2-butanone degraded in activated sludge (30 mg/L) at a rate constant ranging from 0.021 to 0.025/h (Urano and Kato, 1986).
Bridié et al. (1979) reported BOD and COD values of 2.03 and 2.31 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C for a period of 5 d. The ThOD for 2-butanone is 2.44 g/g. Using the BOD technique to measure biodegradation, the mean 5-d BOD value (mM BOD/mM 2-butanone) and ThOD were 3.23 and 58.7%, respectively (Vaishnav et al., 1987).
Photolytic. Synthetic air containing gaseous nitrous acid and exposed to artificial sunlight (λ = 300–450 nm) photooxidized 2-butanone into peroxyacetyl nitrate and methyl nitrate (Cox et al., 1980). They reported a rate constant of 2.6 x 10-12 cm3/molecule?sec for the reaction of gaseous 2- butane with OH radicals based on a value of 8 x 10-12 cm3/molecule?sec for the reaction of ethylene with OH radicals.
The OH radical-initiated photooxidation of 2-butanone in a smog chamber produced peroxyacetyl nitrate and acetaldehyde (Cox et al., 1981). Reported rate constants for the reaction of 2-butanone with OH radicals in the atmosphere and in water are 1.15 x 10-13 and 1.50 x 10-13 cm3/molecule?sec, respectively (Wallington and Kurylo, 1987; Wallington et al., 1988a). The rate constant for the reaction of 2-butanone and OH radicals in the atmosphere at 300 K is 2.0 x 10-12 cm3/molecule?sec (Hendry and Kenley, 1979). Cox et al. (1981) reported a photooxidation half-life of 2.3 d for the reaction of 2-butanone and OH radicals in the atmosphere.
Chemical/Physical. 2-Butanone will not hydrolyze because it has no hydrolyzable functional group (Kollig, 1993).
Combustion in air will produce carbon monoxide (incomplete combustion), carbon dioxide, and water vapor.
At an influent concentration of 1.0 g/L, treatment with GAC resulted in an effluent concentration of 532 mg/L. The adsorbability of the carbon used was 94 mg/g carbon (Guisti et al., 1974).

貯蔵

2-Butanone should be protected from moisture.

輸送方法

UN1193 Methyl ethyl ketone or Ethyl methyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.

不和合性

May form explosive mixture with air. Violent reaction with strong oxidizers, amines, ammonia, inorganic acids; caustics, isocyanates, pyridines. Incompatible with potassium tert-butoxide, 2-propanol, chlorosulfonic acid; oleum. Attacks some plastics. Ketones are incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates

廃棄物の処理

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration

予防処置

2-Butanone vapor and air mixtures are explosive. It reacts violently with strong oxidants and inorganic acids causing fi re and explosion hazard.

2-ブタノン 上流と下流の製品情報

原材料

準備製品


2-ブタノン 生産企業

Global( 0)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度

78-93-3(2-ブタノン)キーワード:


  • 78-93-3
  • 2-Butanone in Methanol
  • 2-BUTANONE
  • METHYL ETHYL KETONE
  • MEK
  • BUTANONE
  • BUTANONE, 2-
  • ETHYL METHYL KETONE
  • FEMA 2170
  • 2-butanal
  • 2-Butanon
  • 2-butanone (MEK
  • 2-butanone (MEK)
  • 2-Butanone(MEK)
  • ethylmethylcetone(french)
  • Ethylmethylketon
  • Ethyl-methylketon
  • femano2170
  • Iethylathylketon
  • Ketone, ethyl methyl
  • Ketone, methyl ethyl
  • ketone,ethylmethyl
  • Meetco
  • Meketone
  • Methyl acetone
  • methyl-2-propanone
  • Rcra waste number U159
  • rcrawastenumberu159
  • 2-Butanone (Controlled Chemical)
  • Ethyl methyl ketone~MEK~Methyl ethyl ketone
  • Ethylmethylketone,99%
  • 2-ブタノン
  • メチルエチルケトン
  • (メチル)エチルケトン
  • エチル(メチル)ケトン
  • エチルメチルケトン
  • メチル(エチル)ケトン
  • 1-メチルプロピオンアルデヒド
  • ブタノン
  • ブタン-2-オン
  • 2ブタノン
  • MEK
  • メチルエチルケトン(2-ブタノン)
  • 2-ブタノン [吸光分析用]
  • 2‐ブタノン
  • 2-ブタノン ACS REAGENT,≥99.0%
  • 2-ブタノン PURISS. P.A.,ACS REAGENT,≥99.5% (GC)
  • 2-ブタノン PURISS. P.A.,ACS REAGENT,REAG. PH. EUR.,≥99.5% (GC)
  • 2-ブタノン REAGENTPLUS,≥99%
  • 2-ブタノン クロマソルブ,FOR HPLC,≥99.7%
  • 2-ブタノン メチルエチルケトン
  • 2-ブタノン(MEK)
  • 2-ブタノン(超脱水)
  • メチルエチルケトン, 2.0 mg/mL in MeOH
  • 分析化学
  • 溶剤 (HPLC用/吸収スペクトル測定用)
  • 吸収スペクトル測定用溶剤
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