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2-ニトロプロパン

2-ニトロプロパン 化学構造式
79-46-9
CAS番号.
79-46-9
化学名:
2-ニトロプロパン
别名:
2-ニトロプロパン;1-メチル-1-ニトロエタン;2ニトロプロパン;2‐ニトロプロパン
英語化学名:
2-Nitropropane
英語别名:
2-NP;i-C3H7NO2;nipars-20;Nipar S-20;b-nitropropane;2-nitro-propan;2-NITROPROPANE;NITROISOPROPANE;ISONITROPROPANE;nipars-20solvent
CBNumber:
CB4854412
化学式:
C3H7NO2
分子量:
89.09
MOL File:
79-46-9.mol

2-ニトロプロパン 物理性質

融点 :
-93 °C
沸点 :
120 °C(lit.)
比重(密度) :
0.992 g/mL at 25 °C(lit.)
蒸気密度:
~3 (vs air)
蒸気圧:
~13 mm Hg ( 20 °C)
屈折率 :
n20/D 1.394(lit.)
闪点 :
99 °F
貯蔵温度 :
Flammables area
溶解性:
H2O: slightly soluble
酸解離定数(Pka):
pK1:7.675 (25°C)
水溶解度 :
1.7 g/100 mL (20 ºC)
Merck :
14,6628
BRN :
1740684
Henry's Law Constant:
8.92 at 20.00 °C, 15.3 at 30.00 °C, 24.4 at 40.00 °C, 36.9 at 50.00 °C (inert gas stripping, Bene? and Dohnal, 1999)
暴露限界値:
Potential occupational carcinogen. NIOSH REL: IDLH 100 ppm; OSHA PEL: TWA 25 ppm (90 mg/m3); ACGIH TLV: TWA 10 ppm (adopted).
安定性::
Stable. Incompatible with strong oxidizing agents, strong bases, copper.
CAS データベース:
79-46-9(CAS DataBase Reference)
NISTの化学物質情報:
Propane, 2-nitro-(79-46-9)
EPAの化学物質情報:
Propane, 2-nitro-(79-46-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  45-10-20/22-68-52/53
Sフレーズ  53-45-61-36/37
RIDADR  UN 2608 3/PG 3
WGK Germany  3
RTECS 番号 TZ5250000
自然発火温度 802 °F
国連危険物分類  3.2
容器等級  III
HSコード  29042000
有毒物質データの 79-46-9(Hazardous Substances Data)
毒性 Acute oral LD50 for rats 720 mg/kg (quoted, RTECS, 1985).
消防法 危-4-2-III
化審法 (2)-194
安衛法 57,57-2
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H341 遺伝性疾患のおそれの疑い 生殖細胞変異原性 2 警告 P201,P202, P281, P308+P313, P405,P501
H350 発がんのおそれ 発がん性 1A, 1B 危険
H412 長期的影響により水生生物に有害 水生環境有害性、慢性毒性 3 P273, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P273 環境への放出を避けること。
P281 指定された個人用保護具を使用すること。
P311 医師に連絡すること。

2-ニトロプロパン 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 N0249 2-ニトロプロパン >95.0%(GC)
2-Nitropropane >95.0%(GC)
79-46-9 25g ¥3900 2018-12-04 購入
東京化成工業 N0249 2-ニトロプロパン >95.0%(GC)
2-Nitropropane >95.0%(GC)
79-46-9 100g ¥11500 2018-12-04 購入
関東化学株式会社(KANTO) 28282-01 2‐ニトロプロパン >96.0%(GC)
2‐Nitropropane >96.0%(GC)
79-46-9 500g ¥12500 2018-12-13 購入
関東化学株式会社(KANTO) 28282-31 2‐ニトロプロパン >96.0%(GC)
2‐Nitropropane >96.0%(GC)
79-46-9 25g ¥2200 2018-12-13 購入
Sigma-Aldrich Japan 130265 2-ニトロプロパン ≥96%
2-Nitropropane ≥96%
79-46-9 5ml ¥2300 2018-12-25 購入

2-ニトロプロパン MSDS


2-Nitropropane

2-ニトロプロパン 化学特性,用途語,生産方法

用途

製造用剤

説明

2-Nitropropane (2-NP) is a clear colourless liquid with a pleasant odour. 2-NP is soluble in many organic solvents including chloroform. Its vapours may form an explosive mixture with air. 2-NP is primarily used as a solvent for organic compounds, coatings, inks, dyes, adhesives, and vinyl resins. Application of 2-NP improves drying time, insures more complete solvent release, provides better flow characteristics, and insures greater pigment dispersion (1,2,3,5). 2-NP has a minor use as an additive in explosives, propellants, and fuels (in racing cars). It also has limited use as a paint and varnish remover. 2-NP serves as an intermediate in the synthesis of some pharmaceuticals, dyes, insecticides, and textile chemicals. It is used for coatings as with vinyl, epoxy paints, nitrocellulose, and chlorinated rubber, in printing inks, adhesives, printing as flexographic inks, maintenance with traffic markings on roads and highways, shipbuilding and maintenance, in furniture, and plastic industries. 2-NP is also used as a solvent in food processing industries for fractionation of a partially saturated vegetable oil. Because of its large-scale use pattern, human exposure to 2-NP has become a health concern.

化学的特性

2-Nitropropane is a colorless liquid.

化学的特性

Colorless liquid.Soluble in water 1.7 mL/100 mL (20C); solubility of water in 2-nitropropane 0.6 cc/100 cc (20C); miscible with organic solvents.

化学的特性

2-Nitropropane exists in equilibrium with 2-propane nitronic acid (HSDB 1988). A 0.01 M aqueous solution has a pH of 6.2. 2-Nitropropane reacts with inorganic bases and amines to form salts which are flammable when dry. 2-Nitropropane is sensitive to detonation when mixed with oxidizers and a mixture of the chemical with ammonium nitrate is a commercial explosive.

物理的性質

Colorless, oily liquid with a mild, fruity odor. 2-Nitropropane was detected in two studies at concentrations of 3.1 and 5.2 ppmv (Crawford et al., 1984).

使用

Solvent (especially for vinyl and epoxy coatings), chemical synthesis, rocket propellant, gasoline additive.

定義

A solvent.

調製方法

Like 1-nitropropane, 2-nitropropane is produced by vapor-phase nitration of propane with nitric acid at elevated temperature and pressure (Baker and Bollmeier 1978). U.S. production in 1977 was put at 30 million pounds (Finklea 1977). Amounts in use have been greatly reduced in recent times because of concern about its carcinogenic potential.

一般的な説明

Colorless liquid with a mild fruity odor. May float on or sink in water.

空気と水の反応

Highly flammable.

反応プロフィール

2-Nitropropane is sensitive to heat. Can react with amines/heavy metal oxides, strong acids, strong alkalis, and chlorosulfonic acid. . The heat of adsorption of 2-Nitropropane on carbon, such as that found in cartridge respirators, is extremely high. Metal oxide catalysts, such as copper oxide or manganese oxide, can initiate ignition, therefore carbon respirators should not be used in environments that have a high vapor concentration of 2-Nitropropane.

危険性

Flammable, dangerous fire risk, moderate explosion hazard when shocked or heated. Liver damage and liver cancer. Possible carcinogen.

健康ハザード

Inhalation causes respiratory tract irritation, headache, dizziness, nausea, and diarrhea. Ingestion causes irritation of mouth and stomach. Contact with liquid irritates eyes and causes mild irritation of skin.

健康ハザード

2-Nitropropane is a lung irritant (HSDB 1988). The acute effects of exposure to 2-nitropropane at 20-45 p.p.m. on workmen were anorexia, nausea, vomiting, diarrhea and severe occipital headache. Complete recovery occurred overnight (Skinner 1947). Hine et al (1978) reported 4 fatalities after exposure of workmen to products containing 11-28% 2-nitropropane. In all 4 cases, the men had been working in confined spaces with poor ventilation for several hours. Presenting symptoms were nausea, vomiting, diarrhea, weakness, dyspnea, chest pain and abdominal pain. Over the next 2 days the patients' condition deteriorated with death occurring within 6-10 d after exposure. The characteristic post-mortem findings were extensive hepatic necrosis and gastrointestinal bleeding. Hine et al (1978) were careful to point out that the only evidence for the involvement of 2-nitropropane was that it was the sole common component of the different products to which the workmen had been exposed.
Two epidemiological studies suggest that no adverse health effects arise as a result of chronic exposure of humans to 2-nitropropane. However, cautious interpretation of the results of both studies is required. Data were gathered from relatively small numbers of subjects who had, in most cases, been exposed to 2-nitropropane for less than 15-20 years. One study included 1481 employees from a 2-nitropropane production plant (NIOSH 1979), while Crawford et al (1985) studied 46 employees of a 2-nitropropane recycling plant, only 18 of whom were considered to have had potential contact with 2-nitropropane.

火災危険

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire.

工業用途

Solvent systems containing 2-nitropropane are used in various coatings, including vinyl, epoxy paints, nitrocellulose and chlorinated rubber, printing inks and adhesives. When mixed with oxidizers, it is used in explosives (HSDB 1988).

安全性プロファイル

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion and inhalation. Human systemic effects by inhalation: anorexia, hypermothty, diarrhea, nausea or vomiting. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Can cause liver and kidney injury, methemoglobinemia, and cyanosis. Very dangerous fire hazard when exposed to heat, open flame, or oxidizers. May explode on heating. Violent reactions with chlorosulfonic acid, oleum. May react with amines + heavy metal oxides (e.g., mercury oxide or silver oxide) to form explosive salts. May ignite on contact with mixtures of carbon + hopcalite, whch are used in some respirators. Hopcalite is a catalyst consisting of coprecipitated copper(Ⅱ) oxide and manganese0 oxide. To fight fire, use alcohol foam, CO2, dry chemical, water spray. When heated to decomposition it emits toxic fumes of NOx.

職業ばく露

2-Nitropropane is used as a solvent for polymers, organic compounds; cellulose, esters; gums,vinyl resins; waxes, epoxy resins, fats, dyes, and chlorinated rubber; as a stabilizer. Its combustion properties have made it useful as a rocket propellant and as a gasoline and diesel fuel additive. 2-Nitropropane also has limited use as a paint and varnish remover. It serves as an intermediate in organic synthesis of some pharmaceuticals; dyes, insecticides, and textile chemicals.

環境運命予測

Photolytic. Anticipated products from the reaction of 2-nitropropane with ozone or OH radicals in the atmosphere are formaldehyde and acetaldehyde (Cupitt, 1980).

代謝

After exposure of male Sprague-Dawley rats to 2-nitropropane (200 p.p.m. by inhalation, or 50 mg/kg intraperitoneally) the major pathway of elimination was by exhalation. Carbon dioxide, acetone and isopropanol were the major metabolites. Exhalation was also the major route of elimination after a dose of 10 mg/kg to chimpanzees (Muller et al 1983). Nonlinear elimination of 2-nitropropane was suggested by studies in which male Sprague-Dawley rats were exposed by inhalation to doses of 20 or 154 p.p.m. radiolabeled 2-nitropropane for 6 h (Nolan et al 1982). Average blood 2-nitropropane concentrations immediately following the 20 and 154 p.p.m. exposures were 0.6 and 7.1 μg/ml, respectively. Furthermore, raising the dose from 20 to 154 p.p.m. caused a greater fraction of the radioactivity to be excreted as unchanged 2-nitropropane. The dose-dependent changes in the elimination of 2-nitropropane may account, at least in part, for the increase in toxicity observed in rats exposed to large concentrations of 2-nitropropane (Lewis et al 1979).
Analysis of incubations of 2-nitropropane with liver microsomes of phenobarbital or 3-methylcholanthrene pretreated male Sprague-Dawley rats indicated that oxidative denitrification of 2-nitropropane produced acetone and nitrite (Ullrich et al 1978). This effect seems not to be dependent on pretreatment with a cytochrome P-450 inducer in other species or strains, since the hepatic microsomes from 5 strains of untreated mice all showed significant, but variable, NADPH-dependent ability to release nitrite from 2-nitropropane (Marker and Kulkarni 1985). Ullrich and coworkers (1978) considered that the reduction of the nitro group of 2-nitropropane to form 2-aminopropane was unlikely, at least in vitro, since the rate of oxidative denitrification of 2-nitropropane was unaltered in microsomal incubations under reduced oxygen tension. Whether any significant nitro group reduction of 2-nitropropane occurs in vivo to produce potentially reactive metabolites is unknown. Speck et al (1982), however, have shown that 2-aminopropane is not mutagenic in Salmonella tester strains.

輸送方法

UN2608 Nitropropanes, Hazard Class: 3; Labels: 3-Flammable liquid.

純化方法

Purify it as for nitromethane. [Beilstein 1 IV 230.]

不和合性

1-Nitropropane, a nitroparaffin compound, forms explosive mixture with air. Contact with heavy metal oxides may cause decomposition. Mixtures with hydrocarbons are extremely flammable. Attacks some plastics, rubber and coatings. May explode on heating. Violent reaction with strong bases; strong acids and metal oxides. Shock-sensitive compounds are formed with acids, amines, inorganic bases and heavy metal oxides. Incompatible with strong oxidizers, combustible materials. 2-Nitropropane reacts with activated carbon causing decomposition. This reaction may occur in activated carbon respirator filters.

廃棄物の処理

Incineration: large quantities of material may require nitrogen oxide removal by catalytic or scrubbing processes. Dilute with pure kerosene and burn with care as it is potentially explosive. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

2-ニトロプロパン 上流と下流の製品情報

原材料

準備製品


2-ニトロプロパン 生産企業

Global( 97)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Haihang Industry Co.,Ltd
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+86 531 8582 1093 export@haihangchem.com CHINA 8266 58
Hubei xin bonus chemical co. LTD
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
SelectLab Chemicals GmbH +49-(0)2383-919350
+49-(0)2383-919354 info@selectlab.de Germany 358 55
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24560 81
Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820
86 (10) 60270825 dtftchem@sina.com China 3395 62
Energy Chemical 021-58432009 / 400-005-6266
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Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
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JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
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79-46-9(2-ニトロプロパン)キーワード:


  • 79-46-9
  • b-nitropropane
  • Dimethylnitromethane
  • i-C3H7NO2
  • Nipar S-20
  • Nipar S-20 solvent
  • Nipar S-30 solvent
  • 2-Nitropropane,97%
  • 2-Nitropane (I, T)
  • Propane, 2-nitro- (I, T)
  • 2-Nitropropane,96%
  • 2-Nitropropane, synthesis grade
  • 2-Nitropropane, 96% 250GR
  • nipars-20
  • nipars-20solvent
  • nipars-30solvent
  • Propane,2-nitro-
  • Rcra waste number U171
  • rcrawastenumberu171
  • sec-Nitropropane
  • NITROISOPROPANE
  • ISONITROPROPANE
  • BETA-NITROPROPANE
  • 2-nitro-propan
  • 2-NP
  • 2-NITROPROPANE
  • 2-ニトロプロパン
  • 1-メチル-1-ニトロエタン
  • 2ニトロプロパン
  • 2‐ニトロプロパン
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