クロロプレタダラフィル
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- CAS番号.
- 171489-59-1
- 化学名:
- クロロプレタダラフィル
- 别名:
- クロロプレタダラフィル
- 英語名:
- Chloropretadalafil
- 英語别名:
- (6R,12aR)-methyl1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate;(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-B]indole-3-carboxylic acid methyl ester;(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylicacidmethyeste;Tadanafil P-1;Methyl (1R,3R;Chloropretadalafil;adalafil impurity 1;Tadaafil Intermediate;B]indole-3-carboxylate;Intermediate of Tadalafil 3
- CBNumber:
- CB5116504
- 化学式:
- C22H19ClN2O5
- 分子量:
- 426.85
- MOL File:
- 171489-59-1.mol
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クロロプレタダラフィル 物理性質
- 融点 :
- 230-232℃
- 沸点 :
- 627.5±55.0 °C(Predicted)
- 比重(密度) :
- 1.445
- 貯蔵温度 :
- Inert atmosphere,2-8°C
- 溶解性:
- クロロホルム(微量)、DMSO(微量)、酢酸エチル(微量)
- 酸解離定数(Pka):
- 16.25±0.60(Predicted)
- 外見 :
- 個体
- 色:
- 白から淡いオレンジ
- InChI:
- InChI=1S/C22H19ClN2O5/c1-28-22(27)16-9-14-13-4-2-3-5-15(13)24-20(14)21(25(16)19(26)10-23)12-6-7-17-18(8-12)30-11-29-17/h2-8,16,21,24H,9-11H2,1H3/t16-,21-/m1/s1
- InChIKey:
- JUKHNCNDFOAFLT-IIBYNOLFSA-N
- SMILES:
- N1C2=C(C=CC=C2)C2C[C@H](C(OC)=O)N(C(CCl)=O)[C@H](C3=CC=C4OCOC4=C3)C1=2
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
クロロプレタダラフィル 価格
もっと(5)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-8730 |
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxylate |
171489-59-1 |
1g |
¥10000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-8730 |
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxylate |
171489-59-1 |
5g |
¥10500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS095485 |
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
171489-59-1 |
1g |
¥7400 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS095485 |
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
171489-59-1 |
5g |
¥20200 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS095485 |
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
171489-59-1 |
10g |
¥34000 |
2024-03-01 |
購入 |
クロロプレタダラフィル 化学特性,用途語,生産方法
説明
Chloropretadalafil is a key synthetic intermediate of tadalafil which is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
化学的特性
White Solid
使用
(1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9- tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic is used as an intermediate in the synthesis of Tadafil, which is used for the treatment of erectile dysfunction.
参考文献
[1] ALAIN DAUGAN. The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1‘,2‘:1,6]pyrido[3,4-b]indole-1,4-dione Analogues[J]. Journal of Medicinal Chemistry, 2003. DOI:
10.1021/jm0300577.
[2] SHI X X, LIU S, XU W Z, et al. Highly stereoselective Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues[J]. Tetrahedron-asymmetry, 2008, 19: 435-442. DOI:
10.1016/J.TETASY.2007.12.017.
[3] ZHANG Y, HE Q, DING H, et al. IMPROVED SYNTHESIS OF TADALAFIL[J]. Organic Preparations and Procedures International, 2005, 37: 102-199. DOI:
10.1080/00304940509355408.
クロロプレタダラフィル 上流と下流の製品情報
原材料
クロロアセチルクロリド
(1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE
(1S,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-Methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
ピペロニル アルコール
準備製品
クロロプレタダラフィル 生産企業
Global( 272)Suppliers
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Zhengzhou Lingzhiyue Technology Co., Ltd
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+86-0371-55074660 +86-13783527580
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Lingzhiyue@aliyun.com |
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3084 |
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Shandong Luning Pharmaceutical Co., Ltd.
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0546-6491488 +8613305469775
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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
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+8613119157289
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13119157289@163.com |
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2971 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
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Hangzhou ICH Biofarm Co., Ltd
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+undefined8613073685410
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sales@ichemie.com |
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Zibo Hangyu Biotechnology Development Co., Ltd
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Mandy@hangyubiotech.com |
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11001 |
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Anhui Ruihan Technology Co., Ltd
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+8617756083858
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daisy@anhuiruihan.com |
China |
994 |
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Capot Chemical Co.,Ltd.
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571-85586718 +8613336195806
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sales@capotchem.com |
China |
29797 |
60 |
Taizhou Tianhong Biochemistry Technology Co., Ltd.
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0523-86132544
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sales@thbiochem.com |
CHINA |
305 |
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Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
171489-59-1(クロロプレタダラフィル)キーワード:
(3R,4R)-1-ベンジル-N,4-ジメチルピペリジン-3-アミン
CIS-オクタヒドロイソインドール
タダラフィル
アミノタダラフィル
N-フェニルプロペニルタダラフィル
N-オクチルノルタダラフィル
(1S,3S)-1-(1,3-ベンゾジオキソール-5-イル)-2-(2-クロロアセチル)-2,3,4,9-テトラヒドロ-1H-ピリド[3,4-B]インドール-3-カルボン酸メチルエステル
(1R,3S)-1-(1,3-ベンゾジオキソール-5-イル)-2-(2-クロロアセチル)-2,3,4,9-テトラヒドロ-1H-ピリド[3,4-B]インドール-3-カルボン酸メチルエステル
タダラフィルケトラクタム (>90%)
D-トリプトファン
(1S,3S)-1-(1,3-ベンゾジオキソール-5-イル)-2,3,4,9-テトラヒドロ-1H-ピリド[3,4-B]インドール-3-カルボン酸メチルエステル
L-トリプトファン
CIS-タダラフィル
(1R,3S)-1-(1,3-ベンゾジオキソール-5-イル)-2,3,4,9-テトラヒドロ-1H-ピリド[3,4-B]インドール-3-カルボン酸メチルエステル
2,3-(メチレンジオキシ)ベンズアルデヒド
CIS-ENT-タダラフィル
ENT-タダラフィル
(1,3-ベンゾジオキソール-5-イル)ヒドロキシ酢酸
- 171489-59-1
- (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-Methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate (Chloropretadalafil)
- (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(chloroacetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxylic acid methy ester
- 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-, methyl ester, (1R,3R)-
- B]indole-3-carboxylate
- (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3
- (1R,3R)-1-(1,3-BENZODIOXOL-5-YL)-2-(CHLOROACETYL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B] INDOLE-3-CARBOXYLIC ACID METHYL ESTER
- (1R,3R)-METHYL-1,2,3,4-TETRAHYDRO-2-CHLOROACETYL-1-(3,4-METHYLENEDIOXYPHENYL)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE
- (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester
- (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
- Tadalafil IMpurity: IMpurity E
- (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b
- (6R.12aR)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl1-1(3,4-Methylenedioxyphenyl)9H-pyrido-[3,4-b]-indole-3-Carbxylate
- (6R, 12aR)-methyl 1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4- Tadalafil
methylenedioxyphenyl)-9H-pyridol[3,4-b]indole-3-
carboxylate
- (1R,3R)- methyl -1,2,3,4-tetrahydro-1-(3,4- methylenedioxyphenyl)-9H-pyrido [3,4-B]indole-3-carboxyl
- Tadanafil P-1
- Tadalafil Chloroacetyle Impurity
- (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9- tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic
- Chloropretadalafil (Methyl (1R,3R)-
- Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetra-hydro-1H-pyrido[3,4-b]indole-3-carboxylate
- methyl(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
- Methyl (1R,3R
- Tadalafil intermediates,(1R,3R)-methyl-1,2,3,4-tetrahydro-2- chloroacetyl-1-(3,4- methylenedioxyphenyl)-9H-pyrido[3,4- B]indole-3-carboxylate
- (1R,3R)-methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-meth...
- An intermediate in the synthesis of Tadalafil, which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.
- Intermediate of Tadalafil 3
- (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]"
- (6R,12aR)-methyl1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate
- (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-B]indole-3-carboxylic acid methyl ester
- (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(chloroacetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylicacidmethyeste
- Methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
- クロロプレタダラフィル