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DL-アミノグルテチミド

DL-アミノグルテチミド 化学構造式
125-84-8
CAS番号.
125-84-8
化学名:
DL-アミノグルテチミド
别名:
DL-アミノグルテチミド;3-エチル-3-(4-アミノフェニル)ピペリジン-2,6-ジオン;3-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン;(3S)-3α-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン;3-(4-アミノフェニル)-3-エチル-3,4-ジヒドロピリジン-2,6(1H,5H)-ジオン;(S)-3-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン;[3S,(-)]-3-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン;シタドレン;オリメテン;2-(4-アミノフェニル)-2-エチルグルタルイミド;エリミナ;3α-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン;エリプテン;(-)-アミノグルテチミド;3-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン;アミノグルテチミド;(±)-P-アミノグルテチミド;D,L-アミノグルテチミド;DL-AMINOGLUTETHIMIDE 99 %
英語化学名:
Aminoglutethimide
英語别名:
Elipten;Ba-16038;Cytadren;ORIMETEN;NSC-330915;AKOS NCG1-0032;AMINOGLUTETHIMIDE;AMINOGLUTETHAMIDE;TIMTEC-BB SBB000711;DL-AMINOGLUTETHIMIDE
CBNumber:
CB5131691
化学式:
C13H16N2O2
分子量:
232.28
MOL File:
125-84-8.mol

DL-アミノグルテチミド 物理性質

融点 :
152-154 °C(lit.)
沸点 :
374.44°C (rough estimate)
比重(密度) :
1.1099 (rough estimate)
屈折率 :
1.6450 (estimate)
貯蔵温度 :
2-8°C
溶解性:
H2O: 0.2 mg/mL, slightly soluble
酸解離定数(Pka):
11.60±0.40(Predicted)
外見 :
neat
色:
white
水溶解度 :
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.
Merck :
14,440
CAS データベース:
125-84-8(CAS DataBase Reference)
NISTの化学物質情報:
Aminoglutethimide(125-84-8)
EPAの化学物質情報:
Aminoglutethimide (125-84-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36
RIDADR  3249
WGK Germany  3
RTECS 番号 MA4026950
国連危険物分類  6.1(b)
容器等級  III
HSコード  2925190100
有毒物質データの 125-84-8(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

DL-アミノグルテチミド 価格 もっと(26)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BCS4006364 DL-Aminoglutethimide 99 %
DL-Aminoglutethimide
125-84-8 5g ¥92000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01BCS4006364 DL-Aminoglutethimide 99 %
DL-Aminoglutethimide
125-84-8 25g ¥369000 2018-12-26 購入
東京化成工業 A1947 DL-アミノグルテチミド >98.0%(HPLC)(T)
DL-Aminoglutethimide >98.0%(HPLC)(T)
125-84-8 5g ¥12800 2018-12-04 購入
東京化成工業 A1947 DL-アミノグルテチミド >98.0%(HPLC)(T)
DL-Aminoglutethimide >98.0%(HPLC)(T)
125-84-8 1g ¥4500 2018-12-04 購入
Sigma-Aldrich Japan A0496000 DL-アミノグルテチミド European Pharmacopoeia (EP) Reference Standard
Aminoglutethimide European Pharmacopoeia (EP) Reference Standard
125-84-8 a0496000 ¥33600 2018-12-25 購入

DL-アミノグルテチミド MSDS


3-(4-Aminophenyl)-3-ethyl-2,6-Piperidinedione

DL-アミノグルテチミド 化学特性,用途語,生産方法

効能

副腎皮質抑制薬, 抗悪性腫瘍薬, エストロゲン生合成阻害薬

化学的特性

White Solid

使用

aromatase inhibitor, antineoplastic, testosterone suppressant

使用

An aromatase inhibitor. Also blocks adrenal steroidogenesis

定義

ChEBI: A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.

適応症

Aminoglutethimide (Cytadren) is a competitive inhibitor of desmolase, the enzyme that catalyzes the conversion of cholesterol to pregnenolone; it also inhibits 11-hydroxylase activity.This drug also reduces estrogen production by inhibiting the aromatase enzyme complex in peripheral (skin, muscle, fat) and steroid target tissues.

brand name

Cytadren (Novartis);C-16038-ba;Crytraden;Doredin;Mamomit;Ormeten.

世界保健機関(WHO)

Aminoglutethimide, a weak anticonvulsant, was introduced in 1960 for use in the treatment of epilepsy. However, its adrenocortical suppressant activity gave rise to serious adverse effects. The FDA decision in 1966 was taken in respect of a preparation indicated in epilepsy. In 1980 preparations containing aminoglutethimide were reintroduced in the USA exclusively for the treatment of Cushing's disease. In 1986 they were also registered in Saudi Arabia for use in Cushing's syndrome and for the treatment of breast cancer. In some other countries these preparations are additionally approved for carcinoma of the prostate.

一般的な説明

Aminoglutethimide, 3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione, is mainly usedto treat Cushing syndrome, a condition of adrenal steroidexcess, a use in which the P450scc inhibition of thiscompound is exploited rather than its aromatase inhibition.Aminoglutethimide is a weak inhibitor of aromataseand has been used successfully in the treatment of estrogen-dependent breast cancer. Because of the developmentof more selective aromatase inhibitors, the use ofaminoglutethimide for its ability to inhibit aromatase is notsupported.

臨床応用

Aminoglutethimide is suitable for use in Cushing’s syndrome that results from adrenal carcinoma and in congenital adrenal hyperplasia, in which it protects the patient from excessive secretion of endogenous androgens. The drug is not curative, and relapse occurs when treatment is terminated. Since aminoglutethimide therapy is frequently associated with mineralocorticoid deficiency, mineralocorticoid supplements may be needed. Aminoglutethimide and metyrapone are frequently used in combination at lower doses of both drugs as an adjunct to radiation or surgical therapy.

副作用

Such a medical adrenalectomy is an efficacious treatment for metastatic breast and prostate cancer, since it diminishes the levels of circulating sex hormones. Glucocorticoids are administered concomitantly to suppress enhanced corticotrophin release. Cortisol is preferable to dexamethasone in this situation because aminoglutethimide markedly enhances the hepatic microsomal metabolism of dexamethasone. Hepatic enzyme induction may be responsible for the development of tolerance to the side effects of aminoglutethimide, such as ataxia, lethargy, dizziness, and rashes.

代謝経路

Following administration of a single oral dose of 14C- aminoglutethimide to rats, guinea pigs, rabbits, and man, more than 89% of the dose is excreted in urine and feces within 72h, and dogs eliminate only 51% in this time. Extensive metabolism occurs in all species, with N-acetylaminoglutethimide being the major metabolite except for dogs and man. In the latter two species, the unchanged drug is the main product excreted. As shown in the pathways, it appears that aminoglutethimide is metabolized by several pathways in man and, of the ten metabolites, only two are present in any quantity, namely N-acetylaminoglutethimide and N-hydroxyaminoglutethimide, the latter increasing during the course of treatment.

DL-アミノグルテチミド 上流と下流の製品情報

原材料

準備製品


DL-アミノグルテチミド 生産企業

Global( 121)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21837 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Shaanxi Dideu Medichem Co. Ltd
+86-15319487004
+86-29-88380327 1015@dideu.com CHINA 3526 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132149 58

125-84-8(DL-アミノグルテチミド)キーワード:


  • 125-84-8
  • 2-(4-aminophenyl)-2-ethylglutarimide
  • DL-Aminoglutethimide 99 %
  • (+/-)-P-AMINOGLUTETHIMIDE INHIBITS CYTOC HROME P
  • Aminoglutethimide(Ag)
  • 3-(4-AMINOPHENYL)-3-ETHYL-2,6-PIPERIDINEDIONE (DL-AMINOGLUTETHIMIDE)
  • (S)-3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
  • 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-quinone
  • 3-(4-azanylphenyl)-3-ethyl-piperidine-2,6-dione
  • DL-Aminoglutethimide,3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione, 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione
  • Aminoglutethimide (200 mg)
  • (RS)-2-(4-AMino-phenyl)-2-ethyl-glutariMide, (RS)-3-(4-AMino-phenyl)-3-ethyl-2,6-dioxo-piperidine
  • 2-(p-aminophenyl)-2-ethyl-glutarimid
  • 2-(p-Aminophenyl)-2-ethylglutarimide
  • 2-(p-Aminophenyl)-2-ethylglutarimide2,6-piperidinedione, 3-(4-aminophenyl)-3-ethyl-
  • 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-
  • 3-(4-aminophenyl)-3-ethyl-6-piperidinedione
  • 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine
  • alpha-(p-Aminophenyl)-alpha-ethylglutarimide
  • Ba-16038
  • Cytadren
  • Elipten
  • Glutarimide, 2-(p-aminophenyl)-2-ethyl-
  • NSC-330915
  • TIMTEC-BB SBB000711
  • 3-(4-AMINOPHENYL)-3-ETHYL-2,6-PIPERIDINEDIONE
  • 3-(4-AMINOPHENYL)-3-ETHYLPIPERIDINE-2,6-DIONE
  • (RS)-2-ETHYL-2-(4-AMINO-PHENYL)-GLUTARIMIDE
  • (RS)-3-(4-AMINO-PHENYL)-3-ETHYL-PIPERIDINE-2,6-DIONE
  • (RS)-3-ETHYL-3-(4-AMINO-PHENYL)-2,6-DIOXO-PIPERIDINE
  • (+/-)-P-AMINOGLUTETHIMIDE
  • DL-アミノグルテチミド
  • 3-エチル-3-(4-アミノフェニル)ピペリジン-2,6-ジオン
  • 3-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン
  • (3S)-3α-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン
  • 3-(4-アミノフェニル)-3-エチル-3,4-ジヒドロピリジン-2,6(1H,5H)-ジオン
  • (S)-3-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン
  • [3S,(-)]-3-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン
  • シタドレン
  • オリメテン
  • 2-(4-アミノフェニル)-2-エチルグルタルイミド
  • エリミナ
  • 3α-(4-アミノフェニル)-3-エチル-2,6-ピペリジンジオン
  • エリプテン
  • (-)-アミノグルテチミド
  • 3-(4-アミノフェニル)-3-エチルピペリジン-2,6-ジオン
  • アミノグルテチミド
  • (±)-P-アミノグルテチミド
  • D,L-アミノグルテチミド
  • DL-AMINOGLUTETHIMIDE 99 %
  • 生化学
  • 試験研究用抗腫瘍剤
  • 交感神経作用薬
  • 酵素阻害剤
  • 抗痙攣薬
  • 抗腫瘍薬
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