RU-58841
RU-58841 物理性質
- 沸点 :
- 493.6±55.0 °C(Predicted)
- 比重(密度) :
- 1.39
- 貯蔵温度 :
- Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- DMF: 33 mg/ml; DMSO: 25 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.16 mg/ml
- 外見 :
- Powder
- 酸解離定数(Pka):
- 15.09±0.10(Predicted)
- InChI:
- InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3
- InChIKey:
- ARBYGDBJECGMGA-UHFFFAOYSA-N
- SMILES:
- C(#N)C1=CC=C(N2C(=O)N(CCCCO)C(C)(C)C2=O)C=C1C(F)(F)F
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H290 |
金属腐食のおそれ |
金属腐食性物質 |
1 |
警告 |
|
P234, P390, P404 |
| H314 |
重篤な皮膚の薬傷?眼の損傷 |
皮膚腐食性/刺激性 |
1A, B, C |
危険 |
|
P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
|
| 注意書き |
| P234 |
他の容器に移し替えないこと。 |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P301+P330+P331 |
飲み込んだ場合：口をすすぐこと。無理に吐かせ ないこと。 |
| P303+P361+P353 |
皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。 |
| P363 |
汚染された衣類を再使用す場合には洗濯をすること。 |
| P390 |
物的被害を防止するためにも流出したものを吸収 すること。 |
|
RU-58841 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
RU-58841 化学特性,用途語,生産方法
説明
RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor (Kd = 1.8, 1.1, 5.6, 1.3, and 1.4 nM for human, rat, mouse, hamster prostate, and hamster flank organ receptors, respectively). In vivo, topical administration of RU-58841 (1-100 μg per animal) reduces size of the flank organ without affecting sex organs in a dose-dependent manner in hamsters. It has no effect on sex organ weight in intact rats when administered percutaneously, subcutaneously, or orally at doses up to 1 mg per animal. RU-58841 (5% v/v) also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.
使用
RU 58841, is a specific androgen receptor antagonist or anti-androgen, that has shown to have effect on hair growth.
製造方法
RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography.
Alternative synthesis of the anti-baldness compound RU58841
Synthesis Reference(s)
A bromine–nitro substitution at tertiary carbon and using 2-nitropropane as leaving group enable a short phosgene-free synthesis of RU58841.
pubs.rsc.org
生物活性
Androgens are mainly produced in the adrenal glands and testes. They are male hormones responsible for sex-related development. The well-known androgen is testosterone. Dihydrotestosterone (DHT) is also an androgen, which is a byproduct of testosterone. Although DHT is important for male development and physical health, it can cause hair loss. RU58841 is a topical anti-androgen drug that counteracts the effects of dihydrotestosterone (DHT) by binding to the androgen receptors of the hair follicles, preventing DHT from interacting with the androgen receptors of the hair follicles. Therefore, the hair shrinkage process does not begin, ensuring that the hair undergoes a normal growth cycle.
RU-58841 上流と下流の製品情報
原材料
準備製品
RU-58841 生産企業
Global( 275)Suppliers
154992-24-2(RU-58841)キーワード:
- 154992-24-2
- RU 58841
- 4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
- 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
- 4-[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl)benzonitrile
- Benzonitrile, 4-[3-(4-hydroxybutyl)-4,4-diMethyl-2,5-dioxo-1-iMidazolidinyl]-2-(trifluoroMethyl)-
- RU 58841(RU-58841)
- 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile RU 58841
- RU 5884
- 4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile(RU 58841)
- RU-58841 E:candyli(at)speedgainpharma(dot)com
- CS-637
- RU 588841
- RU58841;RU 58841;RU-58841
- Benzonitrile,4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(triflu
- 4-[3-(4-hydroxy-butyl)-4, 4-dimethyl-2, 5-dioxy-1-imidazolyl]-2-(trifluoromethyl) benzonitrile
- 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-y...
- HMR-3841
- PSK-3841
- API Setipiprant/RU58841 Powder Dosage Usage Effect and Benefit
- 54RU 58841
- Ru58841
CAS
- 4-[4,4-ジメチル-2,5-ジオキソ-3-(4-ヒドロキシブチル)イミダゾリジン-1-イル]-2-トリフルオロメチルベンゾニトリル
- 4-[3-(4-ヒドロキシブチル)-4,4-ジメチル-2,5-ジオキソイミダゾリジン-1-イル]-2-(トリフルオロメチル)ベンゾニトリル
- RU-58841