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2-フェニルエチルアルコール

2-フェニルエチルアルコール 化学構造式
60-12-8
CAS番号.
60-12-8
化学名:
2-フェニルエチルアルコール
别名:
2-フェニルエチルアルコール;フェニチルアルコル;2-フェニル-1-エタノール;フェニルエタノ-ル;2-フェニルエタノール;フェネチルアルコール;フェニルエチルアルコール;β-フェニルエチルアルコール;2フェニル1エタノル;Β‐フェニルエチルアルコール;2-フェネチルアルコール(Β-);フェニルエタノール,2-
英語化学名:
Phenethyl alcohol
英語别名:
2-PEA;Mellol;beta-PEA;FEMA 2858;(beta-pea);NSC 406252;Phenethanol;beta-P.E.A.;2-Phenethanol;β-Phenethylol
CBNumber:
CB5145283
化学式:
C8H10O
分子量:
122.16
MOL File:
60-12-8.mol

2-フェニルエチルアルコール 物理性質

融点 :
−27 °C(lit.)
沸点 :
219-221 °C750 mm Hg(lit.)
比重(密度) :
1.020 g/mL at 20 °C(lit.)
蒸気密度:
4.21 (vs air)
蒸気圧:
1 mm Hg ( 58 °C)
屈折率 :
n20/D 1.5317(lit.)
FEMA :
2858 | PHENETHYL ALCOHOL
闪点 :
216 °F
貯蔵温度 :
Store at RT.
溶解性:
Miscible with chloroform.
外見 :
Liquid
酸解離定数(Pka):
15.17±0.10(Predicted)
色:
Clear colorless
PH:
6-7 (20g/l, H2O, 20℃)
爆発限界(explosive limit):
1.4-11.9%(V)
水溶解度 :
20 g/L (20 ºC)
Merck :
14,7224
JECFA Number:
987
BRN :
1905732
安定性::
Stable. Substances to be avoided include strong acids and strong oxidizing agents. Combustible.
InChIKey:
WRMNZCZEMHIOCP-UHFFFAOYSA-N
CAS データベース:
60-12-8(CAS DataBase Reference)
NISTの化学物質情報:
Benzeneethanol(60-12-8)
EPAの化学物質情報:
Benzeneethanol (60-12-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  21/22-36/38-36-22
Sフレーズ  26-28-36/37-36/37/39
RIDADR  UN 2810 6.1/PG 3
WGK Germany  1
RTECS 番号 SG7175000
自然発火温度 410 °C
TSCA  Yes
国連危険物分類  6.1
容器等級  III
HSコード  29062990
有毒物質データの 60-12-8(Hazardous Substances Data)
毒性 LD50 orally in rats: 1790 mg/kg (Jenner)
消防法 危-4-3-III
化審法 (3)-1032
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P321 特別な処置が必要である(このラベルの... を見よ)。
P405 施錠して保管すること。

2-フェニルエチルアルコール 価格 もっと(41)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-1754 2-フェニルエタノール
2-Phenylethanol
60-12-8 5g ¥3600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00016142 フェニルエタノール,2-
Phenylethanol,2-
60-12-8 100mg ¥16800 2018-12-26 購入
東京化成工業 P0084 2-フェニルエチルアルコール >98.0%(GC)
2-Phenylethyl Alcohol >98.0%(GC)
60-12-8 500mL ¥4900 2018-12-04 購入
東京化成工業 P0084 2-フェニルエチルアルコール >98.0%(GC)
2-Phenylethyl Alcohol >98.0%(GC)
60-12-8 25mL ¥1800 2018-12-04 購入
関東化学株式会社(KANTO) 13018-1A フェネチルアルコール
Phenethyl alcohol
60-12-8 1L ¥9800 2018-12-13 購入

2-フェニルエチルアルコール 化学特性,用途語,生産方法

外観

無色~ほとんど無色, 澄明の液体

定義

本品は、次の化学式で表される芳香族アルコールである。

溶解性

水に微溶 (2%)。エタノール, エーテル等有機溶媒に易溶。エタノールに極めて溶けやすく、水にやや溶けにくい。

用途

医薬的補助剤(抗微生物)、っ風味剤、香料(特にバラ香料)(MERCK(14TH, 2006))

用途

花精油調合剤及び化粧水に用いる。また防腐剤としても用いられる。

化粧品の成分用途

防腐剤、溶剤、香料

効能

抗菌薬

化学的特性

colourless liquid

化学的特性

Phenylethyl alcohol is a clear, colorless liquid with an odor of rose oil. It has a burning taste that irritates and then anesthetizes mucous membranes.

化学的特性

Phenethyl alcohol is the main component of rose oils obtained from rose blossoms. It occurs in smaller quantities in neroli oil, ylang-ylang oil, carnation oil, and geranium oils. Since the alcohol is rather soluble in water, losses occur when essential oils are produced by steam distillation.
Properties. Phenylethyl alcohol is a colorless liquid with a mild rose odor. It can be dehydrogenated catalytically to phenylacetaldehyde and oxidized to phenylacetic acid (e.g.,with chromic acid). Its fatty acid esterswith lowermolecularmass, as well as some alkyl ethers, are valuable fragrance and flavor substances.
Production. Many syntheticmethods are known for preparing phenylethyl alcohol; the following are currently of industrial importance: 1) Friedel–Crafts reaction of benzene and ethylene oxide: In the presence of molar quantities of aluminum chloride, ethylene oxide reacts with benzene to give an addition product, which is hydrolyzed to phenylethyl alcohol:
Formation of by-products, such as 1,2-diphenylethane, is largely avoided by using an excess of benzene at low temperature. Special purification procedures are required to obtain a pure product that is free of chlorine and suitable for use in perfumery.
2) Hydrogenation of styrene oxide: Excellent yields of phenylethyl alcohol are obtainedwhen styrene oxide is hydrogenated at low temperature, using Raney nickel as a catalyst and a small amount of sodium hydroxide.
Uses. Phenylethyl alcohol is used frequently and in large amounts as a fragrance material. It is a popular component in rose-type compositions, but it is also used in other blossom notes. It is stable to alkali and, therefore, ideally suited for use in soap perfumes.

化学的特性

Phenethyl alcohol has a characteristic rose-like odor and an initially slightly bitter taste, then sweet and reminiscent of peach.

天然物の起源

Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.

使用

phenethyl alcohol is used to mask odor and also as a preservative.

使用

antibacterial

使用

Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).

調製方法

Phenylethyl alcohol is prepared by reduction of ethyl phenylacetate with sodium in absolute alcohol; by hydrogenation of phenylacetaldehyde in the presence of a nickel catalyst; or by addition of ethylene oxide or ethylene chlorohydrin to phenylmagnesium bromide, followed by hydrolysis. Phenylethyl alcohol also occurs naturally in a number of essential oils, especially rose oil.

製造方法

From toluene, benzene or styrene.

Aroma threshold values

Detection: 0.015 ppb to 3.5 ppm; recognition: 1.2 ppm. Aroma characteristics at 1.0%: floral honey, yeasty bready, musty fresh and sweet.

Taste threshold values

Taste characteristics at 20 ppm: mushroom-like, rose floral, sweet, rosy, bready with honey nuances.

応用例(製薬)

Phenylethyl alcohol is used as an antimicrobial preservative in nasal, ophthalmic, and otic formulations at 0.25–0.5% v/v concentration; it is generally used in combination with other preservatives.Phenylethyl alcohol has also been used on its own as an antimicrobial preservative at concentrations up to 1% v/v in topical preparations. At this concentration, mycoplasmas are inactivated within 20 minutes, although enveloped viruses are resistant.Phenylethyl alcohol is also used in flavors and as a perfumery component, especially in rose perfumes.

安全性プロファイル

Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes

安全性

Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur.
LD50 (rabbit, skin): 0.79 g/kg
LD50 (rat, oral): 1.79 g/kg

貯蔵

Phenylethyl alcohol is stable in bulk, but is volatile and sensitive to light and oxidizing agents. It is reasonably stable in both acidic and alkaline solutions. Aqueous solutions may be sterilized by autoclaving. If stored in low-density polyethylene containers, phenylethyl alcohol may be absorbed by the containers. Losses to polypropylene containers have been reported to be insignificant over 12 weeks at 30°C. Sorption to rubber closures is generally small.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

純化方法

Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]

不和合性

Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

2-フェニルエチルアルコール 上流と下流の製品情報

原材料

準備製品


2-フェニルエチルアルコール 生産企業

Global( 312)Suppliers
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60-12-8(2-フェニルエチルアルコール)キーワード:


  • 60-12-8
  • RARECHEM AL BD 0140
  • PHENYL ETHYL ALCHOL
  • PHENYL ETHYL ALCOHOL
  • PHENYL ETHANOL
  • PHENYLETHANOL,2-
  • PHENETHYL ALCOHOL
  • (beta-pea)
  • .beta.-Phenylethanol
  • 1-Phenyl-2-ethanol
  • 2-PEA
  • 2-Phenethanol
  • 2-Phenethyl Alcohol
  • beta-Phenylethanol
  • Ethanol, 2-phenyl-
  • femanumber2858.
  • Hydroxyethylbenzene
  • -Hydroxyethylbenzene
  • Mellol
  • Methanol, benzyl-
  • methanol,benzyl
  • Phenethanol
  • phenylethanol(non-specificname)
  • Phenylethyl, b- alcohol
  • 2-PHENYL-1-ETHANOL
  • Phenylethyl Alcohol (1 mL)
  • 2-Phenylethanol, synthesis grade
  • Phenethyl alcohol,2-Phenylethanol, 2-Phenylethyl alcohol, Benzyl carbinol
  • Phenethyl alcohol, 99% 100ML
  • Phenethyl alcohol, 99% 5ML
  • NSC 406252
  • 2-フェニルエチルアルコール
  • フェニチルアルコル
  • 2-フェニル-1-エタノール
  • フェニルエタノ-ル
  • 2-フェニルエタノール
  • フェネチルアルコール
  • フェニルエチルアルコール
  • β-フェニルエチルアルコール
  • 2フェニル1エタノル
  • Β‐フェニルエチルアルコール
  • 2-フェネチルアルコール(Β-)
  • フェニルエタノール,2-
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