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トシル酸ブレチリウム

トシル酸ブレチリウム 化学構造式
61-75-6
CAS番号.
61-75-6
化学名:
トシル酸ブレチリウム
别名:
オルニド;ブレチリウム·p-トルエンスルホナート;ブレチロール;2-ブロモ-N-エチル-N,N-ジメチルベンゼンメタンアミニウム·4-メチルベンゼンスルホナート;ブレチリウムp-トルエンスルホナート;ブレチリウムトシラート;ダレンチン;トシル酸ブレチリウム
英語化学名:
BRETYLIUM TOSYLATE
英語别名:
ornid;asl-603;bretylol;bretylan;darentin;darenthin;bretylate;esulfonicacid;ulfonicacid(1:1);BretyliuM p-Tolu
CBNumber:
CB5239348
化学式:
C18H24BrNO3S
分子量:
414.36
MOL File:
61-75-6.mol

トシル酸ブレチリウム 物理性質

融点 :
97-99°
溶解性:
H2O: soluble50mg/mL
色:
white
InChIKey:
KVWNWTZZBKCOPM-UHFFFAOYSA-M

安全性情報

主な危険性  Xn
Rフレーズ  20/21/22
Sフレーズ  36
RTECS 番号 BO9450000
HSコード  2923900100
毒性 LD50 in mice (mg/kg): 400 orally; 250 i.m. (Goldenthal)

トシル酸ブレチリウム 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQH-8034 トシル酸ブレチリウム
Bretylium tosylate
61-75-6 250mg ¥104400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQH-8034 トシル酸ブレチリウム
Bretylium tosylate
61-75-6 1g ¥266400 2018-12-26 購入
Sigma-Aldrich Japan 1076352 United States Pharmacopeia (USP) Reference Standard
Bretylium tosylate United States Pharmacopeia (USP) Reference Standard
61-75-6 200mg ¥70900 2018-12-25 購入
富士フイルム和光純薬株式会社(wako) W01USP1076352 トシル酸ブレチリウム
Bretylium Tosylate
61-75-6 200mg ¥73500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCB677370 トシル酸ブレチリウム
Bretylium Tosylate
61-75-6 100mg ¥350000 2018-12-26 購入

トシル酸ブレチリウム 化学特性,用途語,生産方法

効能

抗不整脈薬

化学的特性

White Solid

使用

Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.

定義

ChEBI: The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibril ation.

brand name

Bretylol (Mayne).

一般的な説明

Bretylium tosylate, (o-bromobenzyl)ethyl dimethylammonium p-toluenesulfonate(Bretylol), is an extremely bitter, white, crystalline powder.The chemical is freely soluble in water and alcohol.Bretylium tosylate is an adrenergic neuronal-blockingagent that accumulates selectively in the neurons anddisplaces norepinephrine. Because of this property,bretylium was used initially, under the trade name ofDarenthin, as an antihypertensive agent. It caused posturaldecrease in arterial pressure. This use was discontinuedbecause of the rapid development of tolerance, erratic oralabsorption of the quaternary ammonium compound, andpersistent pain in the parotid gland on prolonged therapy.

臨床応用

Currently, bretylium is reserved for use in ventriculararrhythmias that are resistant to other therapy. Bretyliumdoes not suppress phase 4 depolarization, a common actionof other antiarrhythmic agents. It prolongs the effectiverefractory period relative to the action potential durationbut does not affect conduction time and is categorized asa class III antiarrhythmic agent. Because bretylium doesnot have properties similar to those of the other antiarrhythmicagents, it has been suggested that its action is aresult of its adrenergic neuronal-blocking properties; theantiarrhythmic properties of the drug, however, are notaffected by administration of reserpine. Bretylium is also alocal anesthetic, but it has not been possible to demonstratesuch an effect on atria of experimental animals, except atvery high concentrations. Therefore, the precise mechanismof the antiarrhythmic action of bretylium remains tobe resolved.

トシル酸ブレチリウム 上流と下流の製品情報

原材料

準備製品


トシル酸ブレチリウム 生産企業

Global( 55)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20116 58
Wuhan ariel chemical Co., LTD. 18986259541 027-87840182 QQ:390889093
027-87840182 QQ:390889093 sales@3stc.com China 3611 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32362 50
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9847 79
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 QQ:452520369
+86 (573) 82222643 sales@maya-r.com China 11740 57
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61
UHN Shanghai Research & Development Co., Ltd. +86 (21) 5895-8002
+86 (21) 5895-8628 sales@uhnshanghai.com China 1036 58
HBCChem, Inc. +1-510-219-6317
+1-650-486-1361 sales@hbcchem.com United States 10661 60

61-75-6(トシル酸ブレチリウム)キーワード:


  • 61-75-6
  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzenes
  • asl-603
  • bretylan
  • bretylate
  • bretyliump-toluenesulfonate
  • Bretyliumtosilate
  • bretylol
  • darenthin
  • [O-BROMOBENZYL]ETHYLDIMETHYL-AMMONIUM P-TOLUENESULFONATE
  • BRETYLIUM TOSYLATE
  • BRETYLIUM TOSYLATE ADRENERGIC NEURON BLO
  • BRETYLIUM TOSYLATE, PHARMA
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium
  • Bretyliume tosylate
  • (o-bromobenzyl)ethyldimethyl-ammoniup-toluenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium4-methylbenzenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzen
  • darentin
  • dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate
  • esulfonicacid
  • n-ethyl-n-o-bromobenzyl-n,n-dimethylammoniumtosylate
  • ornid
  • ulfonicacid(1:1)
  • Bretylium Tosylate (200 mg)
  • BretyliuM p-Tolu
  • Retylium tosylate
  • (2-bromobenzyl)-ethyl-dimethyl-ammonium
  • (2-bromophenyl)methyl-ethyl-dimethylazanium
  • (2-bromophenyl)methyl-ethyl-dimethyl-azanium
  • (2-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate
  • オルニド
  • ブレチリウム·p-トルエンスルホナート
  • ブレチロール
  • 2-ブロモ-N-エチル-N,N-ジメチルベンゼンメタンアミニウム·4-メチルベンゼンスルホナート
  • ブレチリウムp-トルエンスルホナート
  • ブレチリウムトシラート
  • ダレンチン
  • トシル酸ブレチリウム
  • アドレナリン遮断薬
  • 降圧薬
  • 抗不整脈薬
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