Thiamet G Discontinued
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- CAS番号.
- 1009816-48-1
- 化学名:
- 别名:
- 英語名:
- Thiamet G Discontinued
- 英語别名:
- CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- CBNumber:
- CB52485666
- 化学式:
- C9H16N2O4S
- 分子量:
- 248.3
- MOL File:
- 1009816-48-1.mol
- MSDS File:
- SDS
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Thiamet G Discontinued 物理性質
- 沸点 :
- 483.2±55.0 °C(Predicted)
- 比重(密度) :
- 1.74±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- H2O: 60°C に温めた状態で 5mg/mL 以上
- 外見 :
- 粉
- 酸解離定数(Pka):
- 13.17±0.70(Predicted)
- 色:
- 白からベージュ
- 光学活性 (optical activity):
- [α]/D -21 to -26°, c = 0.3 in methanol
- 安定性：:
- -20°C の DMSO 溶液で最大 1 か月間保存できます。
- InChIKey:
- PPAIMZHKIXDJRN-UKPHHSARSA-N
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
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| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H317 |
アレルギー性皮膚反応を起こすおそれ |
感作性、皮膚 |
1 |
警告 |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
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Thiamet G Discontinued 価格
もっと(3)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC4390 |
Thiamet G |
1009816-48-1 |
10mg |
￥63000 |
2018-12-26 |
購入 |
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Sigma-Aldrich Japan
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SML0244 |
≥98% (HPLC)
Thiamet G ≥98% (HPLC) |
1009816-48-1 |
5mg |
￥32300 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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SML0244 |
≥98% (HPLC)
Thiamet G ≥98% (HPLC) |
1009816-48-1 |
25mg |
￥96000 |
2024-03-01 |
購入 |
Thiamet G Discontinued 化学特性,用途語,生産方法
使用
As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological
Biochem/physiol Actions
Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.
Thiamet G Discontinued 上流と下流の製品情報
原材料
準備製品
Thiamet G Discontinued 生産企業
Global( 116)Suppliers
1009816-48-1()キーワード:
- 1009816-48-1
- Thiamet G Discontinued
- Thiamet G
- 1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline
- 2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio
- 5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-
- (3aR,5R,6S,7R,7aR)-2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
- (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- Thiamet G0nDiscontinued
- CS-1700
- (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
- Thiamet G_x000b_Discontinued
- Thiamet H
- 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol