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アコチアミド塩酸塩三水和物

アコチアミド塩酸塩三水和物 化学構造式
773092-05-0
CAS番号.
773092-05-0
化学名:
アコチアミド塩酸塩三水和物
别名:
アコチアミド塩酸塩三水和物;アコチアミド塩酸塩水和物;アコチアミド塩酸塩;アコチアミド塩酸塩水和物 (JAN)
英語化学名:
Acotiamide hydrochloride trihydrate
英語别名:
Ym-443;Acotiae;Acotiamide HCl;Unii-nmw7447A9a;Acofide trihydrate;Acotiamide trihydrate;Acotiamide HCl Hydrate;Acotiamide hydrochlorid;Acotiamide HCl Trihydrate;Acotiamide hydrochloride hydrate
CBNumber:
CB52493115
化学式:
C21H31ClN4O5S
分子量:
487.013
MOL File:
773092-05-0.mol

アコチアミド塩酸塩三水和物 物理性質

安全性情報

アコチアミド塩酸塩三水和物 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQV-0184 アコチアミド塩酸塩三水和物
Acotiamide hydrochloride trihydrate
773092-05-0 250mg ¥32400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQV-0184 アコチアミド塩酸塩三水和物
Acotiamide hydrochloride trihydrate
773092-05-0 1g ¥64800 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQV-9365
Acotiamide hcl
773092-05-0 1g ¥108000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQV-0184 アコチアミド塩酸塩三水和物
Acotiamide hydrochloride trihydrate
773092-05-0 5g ¥194400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQV-0184 アコチアミド塩酸塩三水和物
Acotiamide hydrochloride trihydrate
773092-05-0 10g ¥324000 2018-12-26 購入

アコチアミド塩酸塩三水和物 化学特性,用途語,生産方法

効能

消化管運動改善薬, アセチルコリンエステラーゼ阻害薬

商品名

アコファイド (ゼリア新薬工業)

説明

In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.

Originator

Zeria Pharmaceutical (Japan)

brand name

Acofide

アコチアミド塩酸塩三水和物 上流と下流の製品情報

原材料

準備製品


アコチアミド塩酸塩三水和物 生産企業

Global( 115)Suppliers
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Anhui Dexinjia Biopharm Co., Ltd
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Shandong ruiyue Biological Technology Co.,Ltd.
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Henan DaKen Chemical CO.,LTD.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
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Hebei Chisure Biotechnology Co., Ltd.
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career henan chemical co
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Hebei Ruishun Trade Co.,LTD
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Mike@rsbiology.com CHINA 302 58

773092-05-0(アコチアミド塩酸塩三水和物)キーワード:


  • 773092-05-0
  • Acotiae
  • 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3)
  • Acofide trihydrate
  • N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino]
  • Acotiamide HCl Hydrate
  • N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate
  • Acotiamide HCl Trihydrate
  • N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro
  • N-[2-[DI(PROPAN-2-YL)AMINO]ETHYL]-2-[(2-HYDROXY-4,5-DIMETHOXYBENZOYL)AMINO]-1,3-THIAZOLE-4-CARBOXAMIDE
  • Acotiamide hydrochlorid
  • Acotiamide trihydrate
  • AcotiaMide hydrochloride hydrate CAS 773092-05-0
  • Hot sale top quality Acotiamide hydrochloride hydrate with factory price
  • High Quality Acotiamide hydrochloride hydrate
  • N-[2-(Diisopropylamino)ethyl]-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide Hydrochloride Trihydrate
  • Acotamine hydrochloride trihydrate
  • Acotiamide HCl
  • Acotiamide hydrochloride hydrate
  • N-(2-(Diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxyamide monohydrochloride trihydrate
  • Unii-nmw7447A9a
  • Ym-443
  • AcotiaMide hydrochloride trihydrate
  • Acotiamide hydrochloride hydrate Acotiamide HCl 773092-05-0
  • Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0
  • アコチアミド塩酸塩三水和物
  • アコチアミド塩酸塩水和物
  • アコチアミド塩酸塩
  • アコチアミド塩酸塩水和物 (JAN)
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